Endocrine Abstracts

Introduction: Noise in the operating room is an ongoing problem and impacts the outcome of surgery. Noise as stressor can produce a startle reaction and activate fight or flight response of the autonomic and endocrine system. The psychobiology of the stress as assessed by salivary cortisol level is a sensitive measure of allostatic load. In this study, we correlated salivary cortisol levels of the surgical team with noise measurement and also whether the noise in OR subjective...

Background: The clinical heterogeneity of G2 and G3 well-differentiated GEP-NENs make it difficult to choose an effective treatment plan, highlighting the need of molecular imaging in the treatment of NETs patients. It has been suggested that a dual-tracer 68Ga-DOTATATE/18F-FDG grading scoring system could be a useful imaging biomarker. This pilot study aims to validate the prior observation from Chan et al. (BJC 2022) of variability in NETPET scores in G2-G3 WD GEP NENs and a...

The melanocortin-2-receptor (MC(2) receptor), also known as the ACTH receptor, is a critical component of the hypothalamic-pituitary-adrenal axis. The importance of MC(2) receptor in adrenal physiology is exemplified by the condition familial glucocorticoid deficiency (FGD), a potentially fatal disease characterised by isolated cortisol deficiency. MC(2) receptor mutations cause ~25% of cases. The discovery of a MC(2) receptor accessory protein MRAP, mutations of which account...

The melanocortin-2-receptor (MC(2) receptor), also known as the ACTH receptor, is a critical component of the hypothalamic-pituitary-adrenal axis. The importance of MC(2) receptor in adrenal physiology is exemplified by the condition familial glucocorticoid deficiency (FGD), a potentially fatal disease characterised by isolated cortisol deficiency. MC(2) receptor mutations cause ~25% of cases. The discovery of a MC(2) receptor accessory protein MRAP, mutations of which account...

The melanocortin receptor (MCR) family consists of five G protein-coupled receptors (MC1R-MC5R) with diverse physiological roles. MC1R controls pigmentation, MC2R is a critical component of the hypothalamic-pituitary-adrenal axis, whilst MC3R and MC4R have a vital role in energy homeostasis and MC5R is involved in exocrine function.The melanocortin receptor accessory proteins, MRAP and its paralogue MRAP2, are small single-pass transmembrane proteins tha...

Overt hypothyroidism, diagnosed and treated with L-thyroxine pre-pregnancy, affects 1% of pregnancies. Untreated maternal hypothyroidism is associated with adverse obstetric and neonatal outcomes, and even when partially treated the risks of miscarriage and prematurity remain elevated compared to euthyroidism. With increased understanding of the normal physiological changes to thyroid function during pregnancy, there should be a predictive approach to thyroxine ...

Introduction: In the modern day busy clinical practice the communication between patient and care giver is at minimal level. The patients feel apprehensive when advised about the surgical intervention. In such situation they feel the need of detail information from the care givers.Story telling is a tool which can be used for this problem. We intended to study the efficacy of storytelling technique on patients undergoing Hemithyroidectomy for benign cytology.<p class="abst...

Introduction: This case report described a patient who presented with medullary thyroid carcinoma (MTC) requiring a total thyroidectomy and radial neck dissection. Genetic testing performed in the context of MTC revealed RET proto-oncogene mutation. Baseline screening identified bilateral pheochromocytomas requiring treatment with bilateral adrenalectomy. Case report: 60-year-old male patient presented with a neck lump which had been present for few year...

Objectives: To investigate whether there is a sex difference in serum leptin concentration in Chinese Type 2 diabetic patients with and without nephropathy.Methods: Early morning fasting serum leptin concentrations were measured in 34 Type 2 diabetic patients (mean age 62.1) with nephropathy (creatinine 120-450micromol/l and spot urinary albumin creatinine ratio (ACR) > 25 mg/mmol), 12 newly diagnosed diabetic subjects (mean age 62.5) with normoalbumi...

We adapted holistic needs assessment tool used in oncology setting to create a simple tool to assess the learning need of people with adrenal insufficiency. This simple tool consists of 17 items and it allows endocrine nurse educators to obtain a quick assessment on the self-care management knowledge and skill of people with adrenal insufficiency before embarking on adrenal education.The tool 17 items are:Understanding of adrenal i...