Endocrine Abstracts

Introduction: Inflammation has been involved in the physiopathology of diabetic ketoacidosis (DKA). Hematological inflammatory markers such as neutrophil-to-lymphocyte ratio (NLR) and white blood cell count (WBC) can serve as predictive markers for a systemic inflammatory response. This study aimed to evaluate hematological inflammatory markers in T1DM patients with DKA and without-DKA in an uninfected state and to determine their role in the prediction of DKA.<p class="ab...

Introduction: In addition to its role in phosphocalcic metabolism, the vitamin D (vitD) seems to have anti-tumor effects, particularly in colorectal cancer (CRC). The active metabolite of vitD [1,25(OH)2D3], converted by the enzyme CYP27B1, inhibits proliferation and promotes differentiation of CRC cells which express vitamin D receptor (VDR) via the regulation of a high number of genes. The vitD metabolism seems also to regulate inflammatory processes in...

The use of anti-thyroid medication is favoured first line therapy in Graves’ disease (GD). However, relapse rates are high (up to 50%) and definitive therapies of either surgery or radioactive Iodine therapy (RAI) are often considered following an informed decision. The definitive choice taken depends on several factors considered during the patient-doctor interaction. The aim of this study was thus to determine the influence of such factors.A cross...

Introduction: Hodgkin lymphoma is a cancer that affects the lymphatic system. Treatment includes chemotherapy and radiation therapy, which can increase the risk of secondary cancers such as thyroid and ovarian carcinomas. We report a case of a patient who developed secondary thyroid and ovarian cancers after being treated for Hodgkin’s disease.Observation: Mrs LS was diagnosed with Hodgkin disease at the age of 34 and was treated with chemotherapy a...

Background: Prediabetes (PD) is a significant risk factor diabetes mellitus (DM) and as such, behavioral interventions are the primary management for PD. High blood glucose levels alter circulating NLRP3 inflammasome complex activity and correlated interleukins (ILs). There is limited data available on the activity of NLRP3 inflammasome and ILs in sera of patients with PD that may or may have not developed DM. This interventional study assessed the effects of NLRP3 inflammasom...

Introduction: Turner Syndrome (TS) is known to be associated with congenital malformations and a greater incidence of autoimmune disease. Many others organs systems are also affected to varying degrees and at different stages of life such as abnormal liver function. This disease is often detected on routine investigation and is not accompanied by signs or symptoms of liver disease. We report the case of a young Turnerian who presents a disruption of his hepatic balance with a ...

Introduction: Sexual disorders 46 XY DSD are responsible for a range of phenotypic disorders, ranging from an ambiguous phenotype to a complete female phenotype. In this context, we report a cohort of 22 46 XY patients with a female phenotype in order to establish a phenotype-genotype correlation.Results: The average age at diagnosis was 15.5 years (E: 7 days-33 years). The reason for consultation was primary amenorrhea in 16 cases (72.7%), sexual ambigu...

Introduction: Advances in diagnosis and treatment over the years have improved the life expectancy and quality of life for individuals with congenital adrenal hyperplasia (CAH). The inevitable alteration of the hypercortisolism-hyperandrogenism balance with current CAH therapy could be responsible for several anomalies in the gonadotropic axis and compromise fertility. This study aims to investigate this aspect in an aging Tunisian population of patients with CAH.<p class=...

Introduction: Congenital adrenal hyperplasia (CAH) is an autosomal recessive disorder affecting adrenal steroid synthesis. Its treatment aims to achieve a balance between optimal glucocorticoid replacement and normal androgen levels. The long-term outcomes of this condition are poorly studied. The objective of this study is to evaluate the impact of CAH due to 21-hydroxylase deficiency on final height (FH), bone metabolism, and cardiometabolic risk in a Tunisian cohort.<p ...