Endocrine Abstracts

Introduction: Papillary Thyroid Carcinoma is the most frequent malignant tumour of the thyroid gland. It usually progresses slowly and is rarely metastatic. On the other side, fibromatosis are usually benign tumours with infrequent malignant appearances, which affect musculoaponeurotic structures. The aetiology remains unclear, although various possible factors are linked to it such as trauma, genetic predisposition, β-catenin heterozygous mutation, hormone disbalance etc...

Type 2 diabetes mellitus (DM2) is often associated with obstructive sleep apnea (OSA), according to the literature. Current approach in choosing the hypoglycemic therapy is based on individualization, but do not take into account the effect on OSA. The research purpose: to evaluate the effect of various hypoglycemic agents on the characteristics of OSA in patients with type 2 diabetes.Materials and methods: The study included patients with OSA and DM2, t...

Physiological and molecular examinations provided evidence for the receptor-mediated influence of the pineal hormone melatonin on insulin secretion of pancreatic β-cells. The predominant effect is a reduction the rate of insulin secretion transmitted by downregulation of intracellular cAMP concentrations. In addition, there is also evidence for an activation of the PLC-IP3-pathway. Further investigations established the existence of the melatonin-receptor MT1, ...

The use of topical corticosteroids in the treatment of dermatosis, which includes psoriasis, is a common approach. With local use of corticosteroids, an increase in the concentration of corticosteroids in the area of the inflammatory process is noted, therefore local corticosteroids are believed not to have a suppressive effect on the function of the adrenal glands.Purpose: To demonstrate a side effect of hypercortisolism after uncontrolled long-term use...

Patients with type 2 diabetes mellitus (DM) are one of the most vulnerable categories of patients in terms of adverse outcomes of COVID-19 infection.Aim: To assess the features of laboratory and instrumental data in patients with COVID-19 and type 2 DM (unvaccinated) depending on the value of glycated hemoglobin (HbA1c) at the time of the onset of oxygen deficiency.Materials and methods: The study involved 78 patients with type 2 D...

Recent evidence points to a relationship between the severity of Covid-19 infection and iron metabolism. In patients with type 2 diabetes mellitus (DM 2), the prevalence of anemia of chronic diseases exceeds the general population indicators, which may be one of the factors determining the increase in mortality in this category of patients with Covid-19.Aim: To determine the differences between markers of ferrostatus indicators in patients with DM 2 and ...

Objective: To determine the effects of hypoglycemia while sleeping on somnological parameters for patients with type 1 DM.Materials and methods: The study included 57 person with type 1 DM (Group 1 – patients with blood glucose levels (BGL) during sleep <3.9 mmol/l; Group 2 – Patients with BGL – from 3.9 to 10.0 mmol/l. The examination included: daily monitoring of blood glucose by ‘CGMSGold’ (‘MedtronikMINIMED’ (US...

Objective: To establish the differences in terms of sleep for patients with type 1 diabetes, depending on the level of blood glucose levels (BGL) during the night.Materials and methods: The study included 43 participants with type 1 diabetes (Group A – patients with BGL during sleep from 3.9 to 7.4 mmol/l, Group B – 7.5–10.0 mmol/l. Patients had daily monitoring of BGL ‘CGMSGold’ by ‘MedtronikMINIMED’ (USA), polysomnogr...

It is determined that sleep apnea itself can affect the level of HbA1c, thereby affecting the compensation of carbohydrate metabolism in type 2 diabetes.Objective: To determine the quantity and type of sleep apnea in diabetes type 1, depending on the level of HbA1c.Materials and methods: The study involved 50 people with type 1 diabetes without the presence of diabetic autonomic neuropathy or diseases of the pulmonary system and EN...

Introduction: Individuals with cystic fibrosis (CF) frequently exhibit altered insulin and glucose metabolism and many develop cystic fibrosis related diabetes (CFRD). Lung function is influenced by glucose metabolism with changes in glucose metabolism resulting in deterioration in lung function. Recommendations suggest CF patients should have an OGTT annually to screen for the development of CFRD. We examined the OGTT profiles to ascertain whether simpler fasting measures of ...