Endocrine Abstracts

Introduction: Amiodarone is a highly effective drug, used for the treatment of arrhythmias. However, it can cause either hypothyroidism or thyrotoxicosis. It leads to alterations in thyroid gland function or thyroid hormone metabolism, due to its high iodine content. Amiodarone-induced hypothyroidism is common in countries with high iodine dietary intake, and Amiodarone-induced thyrotoxicosis is more prevalent in regions with low iodine dietary intake. A large amount of iodide...

Introduction: Finding the optimal levothyroxine (LT4) dose regime to ameliorate the abnormally low levels of natural thyroid hormones, especially for thyroidectomized patients, is still challenging. Many researchers have studied various LT4 dosage regimen clinically; and ultimately, they proposed multiple variables affecting LT4 requirements including age, gender, body weight, body mass index (BMI), and body surface area (BSA). However, prescribing the most appropriate LT4 dos...

An endocrine specialist pharmacist has been running an adrenal incidentaloma clinic since September 2020. As of Jun-22 258 patients have been seen in clinic and managed using a local protocol. Adrenal incidentaloma patient referrals are screened as per current guidelines on receipt; those measuring <1 cm are declined, suspected adrenocortical carcinomas are seen by a consultant and referred elsewhere if needed. All others are seen by the endocrine pharmacist within 4 weeks...

Gums inflammation (gingivitis) if not treated on time and permitted to grow, ends into periodontitis in which alveolar bone that supports teeth is invaded and destroyed. Juvenile periodontitis is a genetic disorder and can occur without plaque and calculus. It is a disease of people below 30 years of age.Subjects and methods: This cross sectional study involved a total of 160 subjects including 80 chronic periodontitis patients and 80 healthy controls be...

We aimed to evaluate the risk factors for the development of definitive thyroid failure, to analyze the natural course of subclinical hypothyroidism and to quantify the incidence rate of overt hypothyroidism in elderly patients.Two hundred and fourteen patients (186 women and 28 men) over age 60 years with subclinical hypothyroidism and no previous history of thyroid disease were prospectively studied. Subjects were followed up for 6–72 months (mean...

Introduction: Several levothyroxine (LT4) monotherapy dose regimen have been already proposed by different medical scientists which may result in various daily LT4 doses. Comparing the consequences of such dose regimen are rather difficult since they have to be applied on either the same patient or a large study groups. Therefore, a straight forward method would be to simulate the plasma level of thyroid hormones of virtual-patients treated by various dose regimen.<p class...

Introduction: Hyperparathyroidism happens when one or more of parathyroid glands secret excessive parathyroid hormone, causing calcium levels in blood to rise. A diagnosis may be missed or delayed because there are no symptoms or they are vague, like depression, tiredness, losing your appetite in addition to hypercalcaemia symptoms e.g. vomiting, bone and joint pain, dehydration, hypertension, etc. Surgery to remove the parathyroid gland is usually the only way of treating pri...

Background: Diabetes is the disease of family and parents of children with diabetes face different problems which concerns meeting the developmental needs of children and daily control of children with diabetes.Purpose: This article aims to explain how to manage diabetes around the child’s life within the family.Methods and materials: In this qualitative study, data was collected through semi-structured interview technique and...

Background: Diabetes is the disease of family and parents of children with diabetes face different problems which concerns meeting the developmental needs of children and daily control of children with diabetes.Purpose: This article aims to explain how to manage diabetes around the child’s life within the family.Methods & materials: In this qualitative study, data was collected through semi-structured interview technique a...

Introduction: Thyroid hormones have major effects on regulation of metabolism and function of most cells. A number of prevalent diseases during adulthood have been attributed to the intrauterine status during fetal life. In this study, the effect of fetal hypothyroidism on the carbohydrate metabolism during adulthood investigated.Subject and methods: After mating, the pregnant rats were divided in two, the fetal hypothyroidism (FH) and the control (C) gr...