Endocrine Abstracts

Purpose: Papillary thyroid cancer (PTC) has a strong propensity for lymph node metastasis, which is related with local recurrence, and disease-specific survival in the elderly. We evaluated the association between lymph node metastasis and disease multifocality, bilaterality, and other clinicopathological variables to identify risk factors and aid surgical decision-making. The relationship between the number of foci and metastasis to cervical lymph node was also evaluated....

Post-thyroidectomy syndrome is defined as postoperative problems after thyroidectomy without injury of recurrent laryngeal nerve, and including most common symptom such as vocal fatigue, loss of high-pitch, reduced vocal strength, reduced speaking fundamental frequency also can be presented. In a recent systemic review, F0, shimmer, and MPT was significantly deteriorated only in the early period and not in the late period after thyroidectomy. There have been several questionna...

Purpose: This retrospective study is intended to determine the dose of radioactive iodine using thyroglobulin levels measured after two weeks of thyroid hormone withdrawal in patients with differentiated thyroid cancer. Methods : Patients who were diagnosed as differentiated thyroid cancer and treated with radioiodine after total thyroidectomy were enrolled. Serum thyroglobulin test (preTG; ng/dl) was performed 1 week before radioiodine treatment and 2 w...

Purpose: This retrospective study is evaluated the efficacy of three doses of I-131 (1110 MBq vs 3700 MBq vs 5550 MBq) in differentiated thyroid carcinoma patients with cut-off serum thyroglobulin (TG) level after two weeks of thyroid hormone withdrawal for postoperative thyroid remnant ablation.Methods: A total of 97 patients with differentiated thyroid cancer treated with total thyroidectomy and radioactive iodine (RAI) therapy...

Background: Diabetes and renal disease are global burden with increasing prevalence, respectively. Moreover, they are closely related because diabetic nephropathy itself is well known serious complication of diabetes. However, the significance of decreasing fasting blood glucose on the risk of renal complications remains unclear. We identified the effect of chanes in fasting serum glucose level without diabetes mellitus on the renal complication in Korean adults.<p class="...

Purpose: Telomerase reverse transcriptase (TERT) promoter mutations are associated with tumor aggressiveness. The purpose of our study was to demonstrate the ultrasonographic (US) features of TERT promoter-mutated follicular thyroid cancer (FTC) and to evaluate their predictive performances.Materials and methods: Total 63 patients who had surgically confirmed FTC between August 1995 and April 2021 were included in this study. All of them were available f...

Background: The purpose of this study was to assess the role of ultrasound (US) in predicting tumor invasiveness in follicular thyroid carcinoma (FTC) based on the World Health Organization (WHO) classification and telomerase reverse transcriptase (TERT) promoter mutation.Materials and Methods: This retrospective study included 54 surgically confirmed FTC patients who underwent preoperative US and TERT mutation analysis. The WHO classification consisted ...

Objectives: The macrofollicular variant of papillary thyroid cancer (MFV-PTC) is a rare subtype often lending to a challenging diagnosis. This study evaluated the ultrasonographic (US) features and clinical implication of MFV-PTC.Methods: Records of 14 patients histologically diagnosed with MFV-PTC at our institution over a period of 16 years were retrospectively reviewed. Preoperative US features, Bethesda categories determined by fine-needle aspiration...

Background: Some regrowing nodules after radiofrequency ablation (RFA) of symptomatic large benign thyroid nodules are revealed as malignancies in surgery. The aim of the study was to assess the ultrasound (US) characteristic of thyroid nodules diagnosed as cancer later, the predictive factors for cancer after RFA, and the prevention methods for these cancers to avoid RFA.Materials and Methods: The medical records of 22 thyroid nodules with 18 patients w...

Objective: Non-alcoholic fatty liver disease (NAFLD) is a progressive disease caused by a build-up of fat in the liver and onsets with simple steatosis, potentially advancing to non-alcoholic steatohepatitis (NASH) in the presence of inflammation and fibrosis, severely leading to cirrhosis or hepatocellular carcinoma. There is increasing cumulative evidence indicating that sodium-glucose cotransport 2 (SGLT2) inhibitor agents efficaciously alleviate NASH in a novel mouse model...