Endocrine Abstracts

Introduction: Vitiligo is an acquired depigmenting disorder due to destruction of melanocytes. Most authorities believe that the most important pathogenetic mechanism of the disease is autoimmunity. Other autoimmune disorders such as thyroid autoimmune diseases occur commonly in association with vitiligo. This study was designed to determine the role of thyroid ultrasonography as a noninvasive and cost effective diagnostic method for early detection of thyroid disorders in pat...

Introduction: Alopecia areata is a common disorder presenting with severe hair loss in a specific site. This condition is usually accompanied by autoimmune diseases such as autoimmune thyroiditis, lupus erythematosus, vitiligo, myasthenia gravis, diabetes type II, etc. Considering high incidence of thyroid disease in Iranian population, we decided to evaluate the frequency of thyroidal diseases especially autoimmune thyroiditis in patients with alopecia areata.<p class="ab...

The present study was conducted to investigate the signaling pathway involved in betanin against noise and scrotal hyperthermia and to clarify whether it affects oxidative stress, apoptosis and inflammation in testis of rats. Scrotal hyperthermia was induced by heat exposure of rat testicular for 43ºC for 15 min (3 times per weeks for 14 days). Noise induction was done following exposure of rats with 100 decibel noise level for 14 day and 8 h daily similar to real conditi...

Purpose: Transcription factor 7-like 2 (TCF7L2) variants are known risk factors of type 2 diabetes (T2DM).However; this association is not consistent among different populations. The current study aimed at investigating the relationship between rs 7903146, rs 12255372 variants of TCF7L2 and susceptibility to T2DM.Patients and methods: This case control study included 60 diabetic patients and 60 matched unrelated healthy controls. Genoty...