Endocrine Abstracts

Aims: Genetic variations mediating matrix metalloproteinase-2 (MMP-2) expression may result in individual differences in susceptibility to particular diseases. Our aim was to investigate the possible association of certain MMP-2 gene variants with type 2 diabetes mellitus (T2DM) in a Tunisian population.Subjects and Methods: A case-control study involving 310 normoglycemic control subjects and 791 T2D patients was performed. A total of four MMP-2 SNPs (-...

Aims: Few studies investigated the association of genetic difference in metalloproteinase-2 (MMP-2) gene with diabetic retinopathy but with mixed outcome. The aim of the study is to investigate the association between a set of MMP-2 genetic variants and the risk of diabetic retinopathy in an Arab Tunisian population with type 2 diabetes.Subjects and Methods: A retrospective case-control study involving 779 type 2 diabetes patients with or without diabeti...

Cushing’s disease (CD) is rare in paediatric practice but requires prompt investigation, diagnosis and therapy to prevent longterm complications. We report the case of a young 12-year-old patient who presented with probable Cushing’s disease complicated on the bone level by osteopenia. Cushing’s syndrome seems to have been evolving for 2 years, i.e. at the age of 10, manifesting itself by a weight gain of 20 kg in 18 months. Clinically, she presents clear signs ...

Introduction: Papillary thyroid cancer is a cancer with a good prognosis and slow progression. Only 2 to 10% of distant metastases, the most frequent at the pulmonary level, cranial metastases represent 2.5 to 5.8% of cases. Renal metastases are extremely rare. We report a case.Observation: 74-year-old patient, without suggesting, presents papillary thyroid carcinoma in its trabecular variant classified pT2NxM1, discovered following a left iliac metastas...

Introduction: Metformin is a cornerstone in the treatment of type 2 diabetes, but in recent years several studies have shown that metformin use is associated with a 4-24% decrease in vitamin B12 levels. It is estimated that this problem occurs in approximately 10-30% of patients using metformin and may contribute to distal symmetrical polyneuropathy (DSPN), a very common and clinically relevant diabetic complication.Objective: To study vitamin B12 concen...

Introduction: Poor adherence to prescribed diabetic medication is a major contributor to disparities in effective glycemic control among patients with type 2 diabetes mellitus. The purpose of this study was to investigate the association between health literacy level and adherence to diabetic medications among this population.Methods: A cross-sectional survey enrolled 66 patients medically treated for type 2 diabetes mellitus. Patients with dementia synd...

Introduction: In recent years, the technique of ASG has gained much in simplicity, speed and acceptability, using readers more and more reliable. Despite this, some patients do not acquire the skills needed to achieve it. The aim of this study is to evaluate the technical gestures of use of blood glucose readers in current practice.Material and method: This is a prospective descriptive study including 369 diabetics for over a year, followed in diabetic c...

Post parthyroïdectomy hypocalcemia is a frequent situation, generally due to a definitive or transient hypoparathyroïdism.The ‘Hungry bone syndrome’, is a rare severe hypocalcemia etiology, assigned to an excessive osseous avidity, occurring in intense bone remodeling situations like fibrous osteitis or renal osteodystrophy.We report a case of a 41 years old woman, presenting a chronic renal failure, at hemodial...

Introduction: Pregnancy for women with Graves’ disease is at risk for the mother and the newborn. In fact neonatal hyperthyroidism is uncommon, often transient in the context of maternal Graves’ disease (1% of children). Immediate treatment is essential for a good prognosis, prenatal treatment improves foetal and neonatal development.Case report: We report the case of a patient, known for Graves’ disease since 2006, treated initially with ...

Introduction: At the time of diagnosis of medullary thyroid carcinoma (MTC) 10 to 15% of patients have distant metastases, 25% of them develop them over a longer or shorter period of time. The usual metastases concern cervical lymphadenopathy, bone, lung and liver. There are also unusual secondary localisations. We report a case.Observation: A 56-year-old patient who consulted a year after apparition of cervical lymphadenopathy, whose fine needle aspirat...