Endocrine Abstracts

Introduction: Metabolic dysfunction-associated fatty liver disease (MAFLD) is characterized by the presence of hepatic steatosis, which can progress to non-alcoholic steatohepatitis (NASH), fibrosis, and hepatocellular carcinoma. There are no licensed therapies to halt MAFLD progression, despite it is becoming the most important etiology for advanced liver disease.Aim: The aim of the study was to evaluate the therapeutic potential of inorganic nanopartic...

Hyperandrogenism in women, most typically in polycystic ovary syndrome, is associated with insulin resistance and altered morphology and function of adipose tissue but little is known about the direct effects of androgen on adipose. The aims of this study were to investigate (1) distribution and relative abundance of androgen receptor (AR) in mouse adipose tissue (2) effect of temperature on AR expression in brown and white adipose depots (BAT, WAT) and (3) effects of androgen...

Introduction: Hypogonadotropic hypogonadism is the cause of sexual deficiency, sometimes difficult to differentiate from constitutional growth delay (CGD).Clinical case: A 19-year-old male consulting endocrinology for delayed puberty. Pointed to, at 13 years of age, as having had CGD. His medical report include a viral meningitis at 8 years of age and anosmia since 3 years of age. He expressed lack of sexual desire and concern about the size of his genit...

Introduction: Sarcoidosis is a rare systemic disease where clusters of immune cells form granulomas in various organs of the body. Its prevalence ranges from 1-40 per 100,000 people in Europe. Neurological involvement of the disease occurs in 5-10% of cases, with the hypothalamus-pituitary gland being one of the most commonly affected structures.Clinical Case: A 36-year-old male with a history of hypertension, obesity, asthma and OSAS. He went to the eme...

Introduction: Obesity is a chronic condition with great morbidity, mortality and significant economic and psychosocial impact. Bariatric surgery has proven to be an effective therapy for sustained weight loss and has allowed a reduction in medical comorbidity and an improvement in self-esteem and life quality. However, recent evidence reports an increase in eating and substance-related disorders that are diagnosed in the postoperative period worsening the prognosis.<p clas...

Introduction: Morbid obesity (MO) is a major global public health problem, associated with a significant economic burden, both due to its high prevalence and the number and severity of its comorbidities. MO is associated with a high degree of difficulty to lead a normal social and working life. Weight loss is effective in decreasing these risks and to reduce disease severity. Bariatric surgery (BS) is an effective therapy for sustained weight loss and for the improvement of th...