Endocrine Abstracts

Introduction: β-cell function declines progressively in patients with type 2 diabetes (T2D). the fasting C-peptide/glucose ratio (Cp/G) is used for its evaluation. The GLP1 receptor agonist liraglutide improves glucose and weight control, presumably due to improvement of β-cell function and/or mass. This study evaluates the effect of a 6-months’ treatment with liraglutide in β-cell function, measured by Cp/G, in patients with obesity and T2D.<p class="a...

Background: Acute intermittent porphyria (AIP) is an inherited autosomal dominant disorder characterized by hepatic deficiency of hydroxymethylbilane synthase (HMBS)/porphobilinogen deaminase (PBGD), the third enzyme of the heme synthesis pathway. Hyponatremia is one of the main presenting symptoms and it is thought to be related to an inadequate secretion of ADH (SIADH). Since AIP is an uncommon disease, there is little information about how AIP related hyponatremia responds ...

Introduction: Controversy exists regarding type 2 diabetes (T2D) remission rates after bariatric surgery (BS) due to heterogeneity in its definition and patients’ baseline features. We evaluate T2D remission using recent criteria, according to preoperative characteristics and insulin use.Materials and methods: Retrospective study from a cohort of 657 BS performed in a single centre (2006–2011) of which 141 (57.4% women) had T2D. Evaluation of a...

Introduction: Remission of type 2 diabetes (T2D) is a yearned outcome after bariatric surgery (BS). Attention to individuals who do not strictly fulfil remission criteria has been frequently left behind. The aim of this study was to evaluate metabolic control status in patients considered as diabetes ‘non-remitters’.Materials and methods: Retrospective study of 125 patients (59.2% women) with preoperative diagnosis of T2D who underwent BS in a ...

Introduction: Differentiation between Cushing’s disease (CD) and ectopic Cushing’s syndrome (ECS) remains a diagnostic challenge. Currently available tests lack sufficient sensitivity and specificity or are invasive and technically difficult. Recently, an ACTH-UFC index has been proposed to differentiate the two forms of ACTH dependent Cushing’s syndrome (CS) (Ding, 2021). This work aimed to confirm the diagnostic utility of the ACTH-UFC index to differentiate C...

Introduction: Post-surgical hypoparathyroidism (PSHP) is a frequent complication following ENT surgery. Some patients with head/neck cancers require enteral nutrition (EN) due to dysphagia, mucositis after radiotherapy or chemotherapy, or post-surgical anatomical complications. Formulas of calcitriol are not suitable to be administered via enteral feeding tubes, and side effects of systemic antineoplastic treatment (nausea, vomiting) make calcium and phosphate serum levels dif...

Introduction: Hypoaldosteronism can be induced by a deficit of aldosterone production (AldDef) or a mineralocorticoid resistance (MinRes). Experts have proposed to use hyperkalemia-based aldosterone values for this purpose. However, there is no a range of aldosterone values indicating one of this type of hypoaldosteronism. In 2008, Adam W. R.1 hypothesized that the factored aldosterone (FAldo) could be useful differentiating hypoaldosteronism secondary to MinRes fro...

Langerhans cell histiocytosis (LCH) is a rare disease often involving the hypothalamo-pituitary axis. Extreme obesity is frequent, but effective treatment is not. Malabsorptive bariatric surgery techniques are effective for weight loss in hypothalamic dysfunction. Laparoscopic sleeve gastrectomy (LSG) has recently emerged as a restrictive bariatric procedure to be used before biliopancreatic diversion or gastric bypass, thus reducing surgery-associated morbidity in particularl...

Introduction: Primary hyperparathyroidism results in increased bone resorption. The presence of osteoporosis is at present an established surgery criteria.Objective: The aim of this study was to evaluate the changes in bone mineral density (BMD) after surgery in patients with primary hyperparathyroidism.Material and methods: Retrospective study of 58 patients with primary hyperparathyroidism treated by parathyroidectomy from 2004 t...

Introduction: Craniopharyngiomas are benign epitelial tumors located in the suprasellar region and they are associated to several comorbidities. Our aim is to describe hormonal deficiency and complications after surgery.Design: Descriptive study of patients that underwent surgery of craniopharyngioma. Data collected included hormonal levels, clinical data and mortality. Quantitative variables with normal distribution are shown as mean and standard deviat...