Endocrine Abstracts

Introduction: Thyrotropin deficiency is a rare etiology of hypothyroidism. The diagnosis can be easily confirmed in case of low FT4 level associated with normal or low TSH value. In patients with peripheral hypothyroidism treated by levothyroxine, this biochemical profile become difficult to find. Herein, we describe the case of a patient with peripheral hypothyroidism due to radioiodine therapy in whom the diagnosis of central hypothyroidism was made.Ob...

Introduction: Acromegaly is the set of clinical manifestations induced by chronic exposure to an endogenous excess of growth hormone (GH). Most often, acromegaly is related to GH production by a pituitary adenoma. It may be associated with neuroendocrine tumors of the pancreas as part of multiple endocrine neoplasia type 1 (MEN1). Herein, we described a tumor mimicking a carcinoma of the Ampulla of Vater in a patient with acromegaly.Observation: A 54-yea...

Objective: To determine the factors influencing the level of knowledge and attitudes of diabetics consulting in first and third line in the Sousse region (Tunisia).Patients and Methods: We undertook a cross-sectional study. Diabetics were included by proportional sampling in 11 basic health centers and six hospital departments and outpatient clinics of the university hospital centers of Sousse. The developed questionnaire was self-administered in Arabic....

Objective: This study aimed to translate into Arabic and validate the questionnaires "Simplified Diabetes Knowledge Scale" (SDKS), "Diabetes Attitude Scale-3" (DAS-3) and "Diabetes Health Profile-18" (DHP-18) and to study the predictive factors of the level of knowledge, attitudes and quality of life of diabetics in the health region of Sousse.Population and Methods: A methodological study of psychometric validation was carried ou...

Introduction: Antithyroid drugs (ATD) are usually the first-line treatment for Graves’ disease (GD). It represents an effective treatment with good compliance. This therapeutic modality can be the cause of adverse effects including hematological, cutaneous and hepatic complications. The aim of our study is to evaluate the efficacy of ATD as well as its tolerance in patients with GD.Methods: It is a retrospective study that included 76 patients, with...

Introduction: Primary hyperparathyroidism (PHPT) is most commonly sporadic and in rare circumstances, it can develop as part of multiple endocrine neoplasia (MEN). There are few cases described in the literature reporting an association of PHPT with myasthenia gravis and multiple autoimmune syndrome (MAS). These patients may present only with clinical signs of PHPT making it difficult to suspect the coexistence of MAS. Here, we report the case of type 3 MAS in a woman with PHP...

Introduction: Many thyroid conditions are associated with the development of a rapidly progressing goiter and should evoke several diagnoses, some of which may be of poor prognosis.Case-presentation: A 47-year-old female patient with no previous pathological history presented with a large goiter associated with a deteriorated general condition that had been evolving for 3 weeks On examination, she presented with a fever at 39°C, multiple cervical ad...

Introduction: Neurofibromatosis type 1 (NF1) is a rare autosomal dominant disease. Patients affected by NF1 have an increased risk of developing tumors other than neurofibromas, especially of endocrine origin, that’s why this patients should be screened for endocrine lesions. In this report, we describe a patient affected by NF1 who present a thyroid nodule.Observation: A 27-year-old woman was admitted in our department for endocrinological evaluati...

Introduction: Uncontrolled hyperglycemia in diabetes is a common cause of microvascular complications, including diabetic nephropathy (DN). Despite improvements in the management of type 2 diabetes (T2DM), diabetic nephropathy is still associated with high morbidity and mortality. The objective of our study is to evaluate the predictive factors of DN in adults with T2DM in order to prevent its development.Patients and Methods: A retrospective study, incl...

Introduction: Cushing’s disease (CD), a hypercorticism caused by an ACTH-secreting pituitary adenoma, was associated with a 5-year survival of only 50%. Although advances in management have significantly reduced mortality, the results of transsphenoidal surgery, the gold standard in the treatment of CD, vary from patient to patient.Objective: The aim of our study is to evaluate the results of transsphenoidal surgery in CD (evolution, complications) ...