Endocrine Abstracts

Background: Wolfram Syndrome (WFS) is a rare genetic progressive neurodegenerative disorder caused by mutation in the gene encoding Wolframin, a protein located in the endoplasmic reticulum. WFS has an estimated prevalence of 1 in 770 000.The hallmark features are Diabetes Mellitus, Diabetes Insipidus, Optic Atrophy, Deafness(DIDMOAD) and neurodegeneration. Classic WFS1 is inherited in an Autosomal Recessive manner whereas the Non-classic form is Autosomal Dom...

Aim: To determine the incidence of hypocalcaemia and the need for calcium supplementation after thyroid surgery in 120 patients.Methods: A prospective study to determine the incidence of hypocalcaemia by measuring ionized calcium level in 120 patients underwent thyroidectomy at King Abdul Aziz University Hospital, the data included pre- and post-operative ionized calcium level, albumin, free thyroxine, thyrotopin and alkaline phosphatase. As well include...

A 34-year-old T1DM nurse was admitted with a history of recurrent episodes of DKA. In the current admission at our hospital, on detailed history she reported of getting DKA almost every month when her menses would start. She would be following the sick day rules of DKA but it wouldn’t help prevent her going into DKA. No other precipitating factors were found. She was diagnosed as a case of Catamenial DKA and was started on OCP’s to see how what effect it would have o...

A 25-year-old primi 26 weeks pregnant was admitted with B/L flank pain & pleuritic sounding chest pain. She was septic on initial assessment by the Obstetric team and preliminary investigations revealed high inflammatory markers, raised CRP of 336 & deranged LFT’s. Her USS scan suggested possible hepatitis/cholangitis and blood cultures grew E. coli & she was started on IV Ceftriaxone & metronidazole for the same. At day 3 of her admission, she started det...

Like other steroid hormone receptors (SHRs), the ERR binds to IR3 response elements (REs). However, the naturally occurring ERR binding sites are composed of single, extended half-sites (ERREs) that are recognized by the homodimeric ERR. In order to unravel the specific structural reasons and the related functional consequences related to the binding of a homodimer to single extended half-site REs, we conducted a series of complementary structural and biophysical experiments a...

Insulin is a life-saving drug but can be life threatening if not prescribed properly. A prospective, consecutive audit of insulin prescription was carried out on all medical and surgical patients admitted to South Tipperary General Hospital with types 1 and 2 diabetes mellitus in November 2013. The practice was compared with hospital guidelines which are consistent with other hospitals nationally. Three prescribing practices were audited: i) the prescription of insulin on insu...

Hypothyroidism is a common endocrine condition and if untreated can have serious consequences in pregnant women. Generally, TSH receptor antibodies (TRAb) is performed in hyperthyroid pregnant women as high titres can cause foetal hyperthyroidism Neonatal thyrotoxicosis develops in 1% of infants born to thyrotoxic mothers due to placental transfer of TRAb.As part of management of hypothyroid pregnant women, TRAb are checked routinely in our hospital in k...

Introduction: B cell lymphoma of brain is a rare form of lymphoma of brain and it presetting as SIADH is very rare. In this case it was very difficult to find the cause for SIADH with all routine tests. Ultimate diagnosis was by histopathology.Case report: 68 year old gentlemen admitted with vomiting found to be hyponatraemic with serum sodium of 122 mmol/litre. He was known to have chronic lymphocytic lymphoma treated with chemotherapy with good remissi...

Case: A 34-year-old, Saudi male, known case of hypothyroidism with coarse (potato) voice, referred for isotopic thyroid scan. After withdrawing the Eltroxin for one month, thyroid scan was done and showed abnormal uptake rounded in shape and appears bi-lobar, seen highly in the neck, at the midline, between both submandibular glands. No evidence of any uptake at the normal anatomical position of the thyroid gland. Ultrasound of the neck was done and showed large submental mass...

Objective: The objective of this study was to determine level of non-HDL and LDL cholesterol in type 2 diabetic patients with or without coronary artery disease irrespective on lipid lowering therapy and the common factors associated with elevated non-HDL cholesterol.Study design: cross-sectional study: Place and duration of study: diabetic clinic, Aga Khan University Hospital, Karachi. Data of Type 2 diabetes mellitus patients attended clinics during 20...