Endocrine Abstracts

Background: Non-classic adrenal hyperplasia (NCAH), comparatively a rare disease, is characterised by mild to moderate hyperandrogenemia, hirsutism, oligomenorrhea, insulin resistance which incidentally are the hallmarks of polycystic ovary syndrome (PCOS)- a common disorder among reproductive aged women. The data on 17-hydroxyprogesterone (17-OHP)serum levels in NCAH has been reported globally but there is limited data available regarding the normal range among healthy Indian...

Background: An endocrine disruptor is an exogenous chemical or mixture of chemicals that interfere with any aspect of hormone action. It can interfere with the body’s endocrine system and produce adverse cardiovascular, neurological, developmental, reproductive, and metabolic effects in humans. This study aims to evaluate the knowledge, attitude, and practices (KAP) of the medical students regarding the exposure, usage, and long-term harmful effects of Endocrine Disrupt...

Background: Conventional methods of one-way teaching may not involve the integration of clinical skills and may become more inefficient and passive [1]. During the COVID-19 pandemic, limited patient interaction and shift to online lectures greatly reduced the clinical exposure and opportunity of developing interpersonal skills for junior medical students. In this study, we hosted online webinars with case-based teaching for medical students so that they can amalgamate clinical...

Introduction: Offspring of mothers with diabetes have greater risk of adverse metabolic outcome in later life. Increased adiposity is a plausible mediator. We performed a meta-analysis of studies examining adiposity in infants and children in relation to maternal diabetes.Methods: Citations were identified in PubMed and authors contacted for additional data. Fat free mass, fat mass, body fat %, and skinfold thickness were compared in offspring of mothers...

Many patients continue complaining of subjective symptoms of hypothyroidism despite being on adequate doses of levothyroxine. There are about 14 studies involving T3+T4 combination including 7 which were rigorously conducted. Majority of them (11 studies) did not show any benefit of combination therapy. But our local experience has been a little different. We looked at small cohort of 15 patients who were on combination T3+T4 for more than 6 months and were asked...

Many patients continue complaining of subjective symptoms of hypothyroidism despite being on adequate doses of levothyroxine. There are about 14 studies involving T3+T4 combination including 7 which were rigorously conducted. Majority of them (11 studies) did not show any benefit of combination therapy. But our local experience has been a little different. We looked at small cohort of 15 patients who were on combination T3+T4 for more than 6 months and were asked...

Background: McCune Albright Syndrome (MAS) is a rare mosaic disease caused by activating mutation in GNAS, characterized by bone fibrous dysplasia, café au- lait (CAL) and hyper functional endocrinopathies (1). GIPP is the most common endocrinologic manifestation seen more frequently in girls (2). In a few studies, letrozole, tamoxifen, or fulvestrant were effective in decreasing the rate of skeletal maturation and vaginal bleeding (3,4,5).Case Repo...

Introduction: Polycystic ovary syndrome (PCOS) is a complex condition with multi-systemic implications that can greatly impact patients’ lives. To understand and deliver the varied needs of people with PCOS, a substantial onus lies on PCOS researchers to objectively study patient data and formulate evidence-based recommendations. Equitable research is crucial to ensure fair representation of people of various ethnicities and stratify population-specific analysis to have g...

Amiodarone is commonly prescribed anti-arrhythmic drug which can lead to thyroid dysfunction manifesting as either hypothyroidism or hyperthyroidism. This clinical case of amiodarone induced thyrotoxicosis is being reported to highlight the challenges faced during its management. A 72-year-old gentleman was admitted with history of recurrent falls. He had past medical history of non-ischemic cardiomyopathy, CRT, atrial fibrillation, vascular dementia, osteoporosis, primary hyp...

Ectopic ACTH is an infrequent cause of Cushing’s syndrome which can be severe in its presentation and needs immediate management to in order to prevent the complications associated with severe hypercortisolism. This case of ectopic ACTH secretion is being reported who presented clinically as Cushing’s syndrome and later diagnosed to have small cell carcinoma of lung. A 62-year-old previously normally fit and well lady presented with 1-month history of feeling unwell,...