Endocrine Abstracts

Introduction: Whether patients with non-surgical hypoparathyroidism have skeletal muscle dysfunction is not studied. It is also not known if skeletal muscle dysfunction involves respiratory muscles and results in a restrictive lung disease (RLD).Aim: To assess skeletal muscle and pulmonary function in patients with non-surgical hypoparathyroidism, who were asymptomatic for overt muscle and lung diseases.Methods: Thirty patients wit...

Objective: To investigate the effects of BPA on oxidative damage in terms of activity level of antioxidant enzymes in different regions of the rat brain.Background: The ever increasing uses of electronic gadgets are becoming a widespread source of bisphenol-A accumulation. As studies have been reported that low level BPA accumulation may produce neurological effects but still limited studies have re-examined for its adverse effects in terms of acute expo...

Background: NICE guidance (NG18) and East & North Hertfordshire NHS Trust (ENHT) CG048 recommend that in order to prevent macrovascular cardiovascular disease, services for Children and Young People with Diabetes (CYPD) offer monitoring annually from 12 years for microalbuminuria (to detect diabetic kidney disease), hypertension and dyslipidaemia. Anecdotally, elevated blood pressure (BP) readings in clinic were often attributed to anxiety or an incorrect cuff size and wer...

H. gordonii is a supplement of natural origin indigenous to South Africa and known for its appetite suppressant properties. Owing to its acclaimed anorectic activity, the study was aimed to evaluate the effect of H. gordonii supplementation during short-term calorie restriction on appetite regulatory peptides and endocrine markers. Male albino rats were divided into three groups (n=12 in each) – control, calorie restricted (CR, 25% for 5 days), calorie r...

Objective: To investigate the effects of BPA on oxidative damage in terms of activity level of antioxidant enzymes in different regions of the rat brain.Background: The ever increasing uses of electronic gadgets are becoming a widespread source of Bisphenol-A accumulation. As studies have been reported that low level BPA accumulation may produce neurological effects but still limited studies have re-examined for its adverse effects in terms of acute expo...

Calorie restriction (CR), a form of dietary regime which reduces caloric intake below the habitual unrestricted food intake is a strategy to control weight. The benefits associated with CR are numerous but the associated constant feeling of hunger makes adherence to the CR regime difficult. In the present study certain appetite regulatory hormones and endocrine markers during CR were studied. Male Sprague–Dawley rats were randomly divided into control and test groups (<em...

Objective: To prospectively evaluate the results of laparoscopic ileal interposition (II) with diverted sleeve gastrectomy (DSG) for control of type 2 diabetes mellitus (T2DM) and related metabolic abnormalities.Methods: All patients underwent II +DSG. They had T2DM ≥5 years with poor glycemic control despite adequate dosage of oral hypoglycemic agents (OHAs) and/ or insulin. The primary outcome was remission of diabetes (HbA1c <6.5% without OH...

Objective: To prospectively evaluate the results of laparoscopic ileal interposition (II) with diverted sleeve gastrectomy (DSG) for control of type 2 diabetes mellitus (T2DM) and related metabolic abnormalities.Methods: All patients underwent II+DSG. They had T2DM ≥5 years with poor glycemic control despite adequate dosage of oral hypoglycemic agents (OHAs) and/ or insulin. The primary outcome was remission of diabetes (HbA1C <6.5% without OHA...

Keywords: COVID-19, Diabetes Mellitus, PaediatricsIntroduction: COVID-19 has a complex relationship with diabetes. There is anecdotal evidence that it could be causative for new onset diabetes in paediatrics. In this audit, we aim to study our cohort of new onset diabetes in children and young people (CYP) during the COVID pandemic in a DGH setting. We sought to identify any causative or associational link between COVID-19 and new onset diabetes.<p c...

Diabetes is a common presentation in children and young people. We describe a case of undiagnosed cystic fibrosis (CF), where diabetes was the presenting diagnosis. A 14 year old girl presented with a 2-month history of weight loss, abdominal pain, polyuria and polydipsia. Blood glucose was 31.4 mmol/l with ketones of 0.8 mmol/l, and a diagnosis of T1DM was made. Initial bloods showed HbA1c 150 mmol/mol, normal thyroid function, negative TTG, and negative TPO, GAD and IA2 anti...