Endocrine Abstracts

Background: Acinic cell carcinoma of the parotid gland is a rare cancer, and metastatic (M1) disease is uncommon, occurring in around 10% of cases, with ectopic paraneoplastic Cushing being described in only few cases.Clinical case: A 58-year-old woman, with a history of dedifferentiated parotid acinar cell carcinoma, underwent surgery and adjuvant radiotherapy in 2005. In February 2019 the disease recurred with pulmonary, bone and lymph node metastases....

Introduction: The prolactinoma is the most common functioning pituitary tumour. There are few long-term studies on the optimal duration of treatment with dopamine agonists prolactinoma to ensure healing without recurrence after stopping the medication and do not provide a consensus on it or on withdrawal criteria treatment.Objectives: To establish the prevalence of withdrawal of treatment macroprolactinomas and evaluate criteria prolactinoma cure medical...

Premature Ovarian Insufficiency (POI) is defined as impairement of ovarian function in women under 40 years, with a incidence between 1-4% in women of reproductive age. Among the major identified causes of Premature Ovarian Insufficiency, genetic factors related with X-chromosome are widely described. However, autosome defects are less common found and are related generally with genetic mutations instead of structural abnormalities of them. Thefor, we report a relevant case of...

Introduction: Fine-needle biopsy with cytologic evaluation remains the diagnostic test of choice to distinguish benign from malignant thyroid nodules, but fails to classify thyroid nodules in 15% to 30% of cases (indeterminate thyroid nodules-ITN). ‘Rule out’ molecular testing improves the diagnostic accuracy, with high sensitivity and negative predictive value, ranging from 86 to 96%. However, these tests are not widely available, and notably increase costs. <p ...

Introduction: Autoimmune thyroid diseases (AITD) such as Graves’ disease (GD) or Hashimoto’s thyroiditis (HT) are autoimmune, organ-specific diseases probably related to a complex and multifactorial interplay of specific susceptibility genes and environmental exposures. T lymphocytes and their secretory cytokines play indispensable roles in disrupting tolerance. However, their roles are often complex and full of interactions among distinct components of the thyroid e...

Context: Pathological transcriptomic landscape has been the driver of the Molecular Biology in the recent years. Massive RNA sequencing techniques have been extended from bulk RNAseq, to single cell sequencing (scRNAseq) and spot-based spatial transcriptomics (ST), and sometimes laboratory cannot afford all of them. We tried to answer the question about which would be the best option in thyroid gland using Hashimoto’s thyroiditis (HT) context.Method...

In recent years a number of paradigms have changed the way we go about therapy and its monitoring. So, what has changed? Bisphosphonates were until recently the cornerstone of osteoporosis treatment, but in the last few years new drugs and treatment concepts have appeared. Thus, anabolics such as teriparatide are established as the gold standard in patients with high risk of vertebral fractures. In addition, monoclonal antibodies against bone turnover regulators such as denosu...

Introduction: Nutritional status in patients with neuroendocrine tumors (NETs), especially with gastroenteropancreatic origin, may be affected and have an impact on prognosis and survival. Different techniques are currently available to assess nutritional status, but not all of them are accessible in routine clinical practice. In this context, Body composition of NET patients was calculated by computed tomography (CT) at L3 level to evaluate its importance on clinical prognosi...

Introduction: Type 2 Diabetes Mellitus (T2DM) is a multifactorial and complex chronic disease characterized by insulin resistance and a dysfunctional adipose tissue. T2DM patients usually present a state of low-grade inflammation due to a dysregulation of the cytokine production. Consequently, this seems to contribute to insulin resistance and beta cell failure associated with the progression of this disease.Objective: To examine expression of Interleuki...

Object: Nonfunctioning pituitary adenomas can experiment recurrence and/or progression (R/P) several years after surgery in about 15–50% of patients. There is few evidence about risk factors that could predict R/P. The aim of this study is to identify them and describe our experience through a long term of follow-up in pituitary macroadenomas.Methods: Retrospective cohort analysis of 64 patients who underwent surgery between 1990 and 2013. The main ...