Endocrine Abstracts

Background: Immuglobulin 4 (IgG4) is the least common subtype of Immoglobulin G. However due to its unique characteristic it has been the focal point of many research projects, which eventualy led to the discovery of the sytemic fibro-inflammatory disorder called IgG4-Related Disease. The potential role of IgG4 in the pathogenesis of autoimmune thyroid diseases has been also suggested. However, the amount of evidence is still limited, especially in Graves Disease (GD).<p c...

Background: Graves disease with elevated Immunoglobulin G4 serum concentration is a novel subtype of Graves disease (GD), which seems to be particularly associated with Graves orbitopathy (GO). It occurs in 17.6% of patients with GO and 5.4% of patients with GD without GO. In this study, we compare multiple magnetic resonance imaging (MRI) features of GO with elevated IgG4 serum concentration (IgG4-GO) with the classic GO subtype without IgG4 elevation. No such research has be...

Background: The impact of subclinical hyperthyroidism (sHT) on lipids concentration is still unclear. The aim of the study was to prospectively evaluate the changes in lipid profile in patients with sHT and following restoration of euthyroid state.Patients and methods: The studied group consisted of 44 patients (37 females, 7 males), diagnosed with endogenous sHT in the course of either toxic multinodular goiter, diffused thyroid autonomy or autonomously...

Objective: Sperm cells are produced in the testes by the Sertoli cells. These cells produce Inhibin B and they are stimulated by FSH. Can Inhibin B be a good marker of spermatogenesis? Should we use other marker (FSH?, testosterone?)Design: Prospective study.Patients: We examined 71 patients with infertility.Methods: Semen analysis and hormonal analysis was performed. Semen analysis was performed according to...

Background: Thyroid disease in pregnancy is common with hypothyroidism predominating.Objectives: To determine the aetiology of thyroid disease in patients attending an antenatal thyroid clinic, their baseline biochemical and therapeutic characteristics as well as subsequent management.Subjects/setting: 114 women with a mean 31 years (±5) age were seen by a consultant endocrinologist in the antenatal thyroid clinic, between Sep...

Background: Pheochromocytoma and paraganglioma (PPGL) are rare endocrine tumours that secrete catecholamines. Methoxycatecholamines in free plasma or fractionated methoxycatecholamines in 24-hour urine collections are the recommended tests for the diagnosis of pheochromocytoma, based on which patients are referred for surgical removal of the adrenal gland. However, false-positive results from these tests remain a problem and some patients are referred for adrenalectomy due to ...

Familial non-medullary thyroid cancer (FNMTC) constitutes about 3–9% of all thyroid cancers. One of the genes believed to predispose to non-syndromic FNMTC is FOXE1. It contains a polyalanine tract (polyAla) with a variable number (11 – 22) of alanine residues. This length polymorphism could lead to changes in the FOXE1-encoded protein (FOXE1 transcription factor) structure and predispose to papillary thyroid cancer (PTC). The aim of the st...

Aim: Loss of protective sensation (LOPS) commonly precede Diabetic foot ulcer (DFU) which is one of the most fearsome/serious diabetic complications and the leading cause of foot amputation in T2D patients. However, the prevalence of this high risk state is unknown.Methods: To estimate the presence of LOPS among hospitalized diabetes patients in internal wards, vibration perception and 10-g monofilament tests were done. Patients with foot ulcer or status...

Analogues of somatostatin are widely used in management of neuroendocrine tumors. The “classic” indications for this treatment are: acromegaly and NETs of midgut to diminish symptoms caused by hormonal overproduction and slow down the tumors’ growth. However we consider the use of this medication also in the other cases in which we confirm the presence of somatostatin receptors in tumor by somatostatin receptor scintigraphy.We would like t...

Background: Basal-Bolus (BB) insulin treatment is increasingly used in uncontrolled diabetes patients during hospitalization and is commonly recommended on their discharge. However, the extent of adherence with this recommendation is unknown.Aim: To determine the short term adherence of type 2 diabetes mellitus (T2DM) patients discharged from internal medicine wards with recommendation for BB insulin treatment.Methods: Prescription...