Endocrine Abstracts

Introduction: Pituitary ACTH-dependent Cushing´s disease and acromegaly are rare conditions. Pituitary adenomas co-secreting GH and ACTH are even more unusual.Case report: A 29-year-old patient, mother of three children, long-term follow-up by an endocrinologist for a thyroid struma without an autoimmune basis, was sent in April 2023 for further examination for detection of hypercortisolemia and insufficient suppressibility in the overnight 1 mg dex...

Within the synovium of patients with rheumatoid arthritis (RA), synovial fibroblasts generate active corticosteroids through expression of 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1). In vitro, this enzyme is strongly up-regulated by pro-inflammatory cytokines such as tumour necrosis factor α (TNFα) and IL1β. In this study, we determined the relationship between inflammation and global 11β-HSD1 activity in vivo, in a clini...

With an aging population the number of total joint replacements performed due to end-stage osteoarthritis is increasing. Critically, a significant proportion of patients report dissatisfaction following surgery, with around 10% of hip and 20% of knee OA patients developing chronic postoperative pain. Obesity is a well-known risk factor for the development of OA. Pre-surgical obesity has been previously associated with worse clinical outcomes following arthroplasty. Therefore, ...

Introduction: It is essential that children and young people with diabetes are supported to manage their diabetes effectively to prevent the development of early complications. However, the common clinical challenge is difficultly in engaging adolescents and young people to achieve good glycaemic control in their diabetes management. Solution Focus Therapy (SFBT) has been found to be especially beneficial with children, adolescents and teenagers because it is a brief model tra...

Aim: The aim of this study was to evaluate hormonal disturbances and adipokines levels in girls with oligomenorrhea.Materials and methods: The study comprised a group of 46 girls, aged 16–18 years, who were diagnosed with oligomenorrhea, and a control group with 37 healthy girls, aged 16–18 years, with no diagnosed menstrual disorders. In the first stage of the study, all girls had their medical history assessed. Subsequently, anthropometric me...

Objectives: The objective was to evaluate effects of hyperthyroidism and hypothyroidism on bone metabolism in premenopausal women with special emphasis to osteoprotegerin (OPG) and vitamin D3 (vD).Materials and methods: A total of 119 women aged 18–52 years were studied (38 with recently diagnosed hyperthyroidism; 40 with newly diagnosed hypothyroidism; 41 healthy women as controls). Patients were followed up for a period of 1 year. BMD, ...

University Hospitals Dorset (UHD) has over 1,000 thyroid patient contacts annually. These are primarily patients with autoimmune hyperthyroidism and are treated by titration of Carbimazole. Dose adjustments are made by a healthcare professional (HCP) based on the results of thyroid function tests. Once the test results are available, the HCP decides on a prescription dose and communicates this to the patient, which is time-consuming and introduces delays. This project aims to ...

Introduction: Asprosin, a novel adipokine, is a circulating hormone mainly secreted by white adipose tissue. Asprosin is encoded by the penultimate 2 exons of the fibrillin 1 (FBN1) gene. Protein product of FBN1 is profibrillin-1, which undergoes a proteolytic cleavage by furin enzyme to produce mature fibrillin-1 and asprosin. Literature data indicated that asprosin is involved in the development of diabetes, obesity, cardiomyopathy, cancer, and polycystic o...

Both therapeutic glucocorticoids (GCs) and chronic inflammation are powerful inducers of systemic bone loss, resulting in osteoporosis and increased morbidity. Whilst GCs suppress inflammation, it is unclear how these factors interact to determine net bone metabolism. We investigated the balance between osteo-protective and osteo-destructive properties of GCs in the TNF-tg model of chronic inflammatory disease. Wild-type (WT) and TNF-tg mice were treated with corticosterone (1...

The aim of the study was to analyze the influence of feed from different production systems on food intake, body chemical composition and plasma leptin concentrations in rats. It is expected, that organically produced feed influences positively rat organism, in that hormone balance. Leptin regulates energy intake and expenditure, as well as basic functions of many tissues.The experiment was conducted in 104 Wistar male rats divided into 16 dietary groups...