Endocrine Abstracts

Background : Omentin, also known as intelectin-1, is a member of the family of adipose tissue-related hormones known as adipokines, that exert anti-inflammatory, anti-atherosclerotic, and cardiovascular protective effects. Omentin expression has been detected in adipocytes as well as in a variety of extra-adipose tissues, including the ovary. Interestingly, omentin expression in the pituitary has been shown to be regulated by pituitary hormones. These observations led us to in...

MA is a marker of greatly increased cardiovascular morbidity and mortality in T2DM patients.Objective: To perform a prospective study of normoalbuminuric T2DM patients, analysing the association between CVRF at baseline and the development of MA at follow-up.Materials and methods: The prospective observational study was performed at Montes de Barbanza public health center, a specialized secondary referral center, which provides ser...

Background: The association between hypoglycaemia and CVEM is controversial. It is not ethical or practical to design RCTs to study this association as the primary clinical outcome measure. Therefore, utilization of epidemiological principles to study this association is essential.Objective: To systematically explore the data from MA, RCTs and OBS on hypoglycaemia and CVEM applying Bradford Hill criteria [strength, consistency, dose response or biologica...

Introduction: The time, degree and mode of pituitary function deterioration in patients with PROP1 mutation is not fully known and understood.Aim: To investigate the time and mode of pituitary function deterioration in the families/sporadic patients with PROP1 mutation during longitudinal observation.Methods: We performed a retrospective longitudinal (33 years, SD=12) analysis of 22 patients (11M/11W) with PROP1 mutation, including...

Introduction: The mode of pituitary function deterioration in patients with PROP1 mutation is not fully known and understood. The function of adrenal axis requires special attention.Aim: To investigate the time/mode/markers of pituitary function deterioration in families/sporadic patients with PROP1 mutation during longitudinal observation.Methods: We performed retrospective longitudinal (36.4 years, s.d. = 13.6) analy...

Background: Craniopharyngiomas are rare, relatively benign, slowly growing intracranial tumors originating in pituitary gland embryonic tissue. They may present at any age, with two peaks of occurrence in children and in older adults. Clinical symptoms are the result of mass effects. Treatment options include surgery, radio- and chemotherapy and unfortunately are connected with a high ratio of postoperative pituitary insufficiency.Aim: To present the lon...

Background: HNF1B-MODY is a rare autosomal dominant monogenic form of diabetes coexisting with kidney abnormalities.Objectives: Identification of altered serum metabolites among HNF1B-MODY patients and investigating its function in syndrome pathogenesis.Methods: We recruited patients with HNF1B-MODY (N=10), HNF1A-MODY (N=10), polycystic kidney disease: non-dialyzed and dialyzed ...

Background: Gestational diabetes mellitus (GDM) is one of the most common complications during pregnancy, with a globally increasing incidence that significantly affects maternal and infant health. Currently, there is a lack of effective early diagnostic markers for GDM. Therefore, it is necessary to identify diagnostic biomarkers for early screening of GDM during pregnancy. Circular RNA (CircRNA) has been found to be a structurally unique non-coding RNA, more stable than line...

Introduction: Adults with Turner syndrome (TS) are at increased risk of cardiovascular morbidity and mortality. The aim of this study was to evaluate the compliance with clinical guidelines (Bondy 2007) in measuring metabolic profiles in adults with TS.Methods: Case notes of patients attending a dedicated TS clinic were studied. Variables assessed included anthropometric measurements, blood pressure (BP), fasting plasma glucose (FPG), HbA1c, fasting lipi...

Androgens are increasingly known to play an important role in female health, development and well being. Alongside a controversial increase in androgen therapy there is a realisation that what actually constitutes androgen insufficiency is poorly understood. The aim of this study was to establish circadian profiles for salivary testosterone in healthy women from the age of 19 through 69 year old at 3 points during the menstrual cycle. Females were subdivided into these groups:...