Endocrine Abstracts

Introduction: The good expression of somatostatin receptors in neuroendocrine tumor tissue enables effective treatment with peptide receptor radionuclide therapy (PRRT). To date, there is no clear consensus on the optimal PRRT arrangement due to the possibility of the use of different radiopharmaceutical regimens. In theory, the simultaneous use of two radionuclides (90Y and 177Lu) with different energy and radiation ranges should be more effective than monotherapy. The main o...

Introduction: Visfatin belongs to adipokines, i.e. hormones produced mainly by adipose tissue; its expression and role have been described in many organs, where it regulates energy metabolism, insulin resistance and inflammatory reactions. Moreover, the level of visfatin changes during pregnancy and in obese women and those with obesity related pregnancy pathologies: preeclampsia (PE), gestational diabetes (GDM) or intrauterine growth restriction (IUGR) its level increases. Th...

Introduction: Asprosin, a novel adipokine, is a circulating hormone mainly secreted by white adipose tissue. Asprosin is encoded by the penultimate 2 exons of the fibrillin 1 (FBN1) gene. Protein product of FBN1 is profibrillin-1, which undergoes a proteolytic cleavage by furin enzyme to produce mature fibrillin-1 and asprosin. Literature data indicated that asprosin is involved in the development of diabetes, obesity, cardiomyopathy, cancer, and polycystic o...

Introduction: The aim of our study was to assess the values of total cholesterol, HDL-C, LDL-C and triglycerides before and after treatment with metformin in patients with polycystic ovary syndrome (PCOS) and normal lean.Material and methods: 32 patients received metformin 1500 mg/day in three divided doses. Lipids measurements were performed to each patient with PCOS twice: before and after 6 months of treatment with metformin.Res...

: Hyperinsulinemia is one of biochemical features of polycystic ovary syndrome (PCOS). Metformin is a common drug used in PCOS. Recent studies have shown that metformin has impact on clinical and biochemical parameters in PCOS patients. The aim of our study was to assess retrospectively the influence of metformin on total testosterone, sex hormone binding globulin (SHBG) and free androgen index (FAI) in women with PCOS in polish cohort. A total of 54 patients with PCOS and irr...

Introduction: Thyroid hemiagenesis (TH) is characterised by congenital absence of one thyroid lobe.Aim: To assess possible association between TH and concomitant alterations of other structures derived from pharyngeal apparatus, which might potentially impact calcium-phosphate balance.Materials and methods: Studied group: 20 patients with TH. Control group: 20 subjects with bilobed thyroid, matched for age and gender. Serum concent...

Objectives: The aim of this systematic review was assessment of clinical efficacy of pegvisomant (PEG) in the treatment of adult patients (age ≥18 years) with acromegaly.Methods: The review was conducted according to the Cochrane Collaboration guidelines and polish recommendations of The Agency for Health Technology Assessment and Tariff System. Since acromegaly is a rare disease, not only randomized clinical trials (RCTs), but also real world data...

Introduction: Omentin, also known as intelectin-1 (ITLN1), is a novel adipokine produced predominantly by visceral adipose tissue, which improves insulin sensitivity. Decreased levels of ITLN1 have been reported in the serum of obese and polycystic ovary syndrome patients, as well as in the serum and adipose tissue of obese Meishan (MS) compared to normal weight Large White (LW) pigs. However, the role of ITLN1 in female reproduction at different metabolic status is still unkn...

To maintain proper fertility the balance between formation and luteolysis of corpus luteum (CL) are necessary and strictly controlled events in female reproduction. Degeneration of CL is correlated with apoptosis and autophagy as well as connected with decreased progesterone (P4) level. Resistin is a new key player in the regulation of luteal cells function; our previously study showed that resistin have negative effect on P4 synthesis. Thus the aim of the present study was to...

Introduction: Lymphocytic hypophysitis is rare in children, with only <100 cases described in the medical literature, of which only a few are biopsy-proven. Usually results in hypophysis and pituitary enlargement. Arginine vasopressin deficiency and growth retardation are the most significant presenting symptoms in children with hypophysitis, different from teenagers in whom adrenal insufficiency, hypogonadism, headache, or diplopia might be the leading ma...