Endocrine Abstracts

Introduction: The most common causes of hypercalcemia are primary hyperparathyroidism and malignancy. Malignancy-related hypercalcemia occurs in approximately 20% - 30% of all cancer patients during their clinical course and mainly affects patients with solid tumors such as breast carcinoma.Case Report : 57 yrs old woman was referred for hypercalcemia and osteoporosis. Laboratory: calcium 2.8 mmol/l (normal range 2.15 - 2.55) calculated ionized calcium 1...

Introduction: Parathyromatosis is a rare cause of recurrent hyperparathyroidism defined as small nodules of hyperfunctioning parathyroid tissue in the soft tissues of the neck or mediastinum. The most common cause is probably the implantation of parathyroid cells into surrounding tissue during surgery and the risk of parathyromatosis increases with repeated parathyroid surgery. There is an overlap in the histologic features in parathyromatosis, atypical adenoma, and parathyroi...

We have collected an extensive record of more than 8000 patients with a thyroid carcinoma over the years 1946–2005. In all cases, the diagnosis was done by the histology examination carried by a pathologist. Those records were classified by their dimension and the extent of the thyroid gland. This classification is used as a basis for the treatment decision. Tumors of the bigger size needs radiotherapy with I 131 whereas the smaller tumors are subject of observation and r...

There are more registered Independent Nurse Prescribers than ever before, and with the advent of paediatric specific prescribing courses and more advanced clinical practice degrees, these numbers will certainly increase. The advantages of practising as an independent nurse prescriber can benefit patient care, improve patient safety, and enhance the overall quality of care a patient receives. This presentation will explore these concepts and introduce advanced clinical skills i...

This session will focus on spermatogenesis and pubertal development in boys, emphasizing the use of the Tanner staging system in clinical practice. Implications of early and delayed puberty will be discussed, plus normal pubertal development, and its relevance in sperm banking for children undergoing cancer treatment....

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The population of follicles within the mammalian ovary declines steadily with age. The majority of follicles in the ovary are at the primordial (resting) stage of development, each consisting of a small oocyte surrounded by a single layer of flattened granulosa cells (GCs). The rate at which follicles enter the growing phase, involving oocyte growth and GC shape change and proliferation, is a major determinant of the rate at which the reserve of primordial follicles is deplete...

Epigenetic mechanisms are gaining increasing interest in oncology, both as drivers of tumourigenesis and as potential novel therapeutic targets. This is particularly relevant in neuroendocrine neoplasms (NENs), as a key tumour suppressor gene involved in NEN development, multiple endocrine neoplasia type 1 (MEN1), plays a critical role in epigenetic regulation of gene expression through micro RNA (miRNA) and histone modification pathways. MEN1 mutations can g...

Background: There are a variety of growth hormone delivery devices (GHDD) available to children requiring growth hormone (GH) therapy. Many paediatric endocrine nurses can offer patients and their families a choice of the products that are available, which can sometimes be overwhelming. However, factors such a licenced clinical indications have to be considered, as well as cost. This study explored nurses viewpoints on GHDD.Aim: The purpose of this proje...

Pancreatic neuroendocrine tumours (PNETs) are increasing in incidence, and have a 5-year survival rate of <50%. This is largely because, despite recent advances, current treatments are often ineffective, and therefore additional therapeutic agents are required. Epigenetic inhibitors may offer a novel class of anti-cancer drugs, as PNETs harbour mutations of chromatin remodelling genes including ATRX and DAXX, while menin, encoded by MEN1, interac...