Endocrine Abstracts

Menopause timing is highly variable, having a direct effect on reproductive lifespan, fertility and health outcomes in later life. Endocrine and imaging tests only record changes in ovarian function that have already taken place, thus disabling early prediction and identification of women with reduced reproductive lifespan. Human genetic studies have attempted to overcome this problem by identifying genetic markers associated with menopause timing and fertility. Using data fro...

Numerous epidemiologic studies have associated hyponatremia with both osteoporosis and bone fractures. Disordered bone metabolism with hyponatremia occurs primarily by direct sodium-sensing mechanisms on osteoclasts that are independent from osmolality. Additional effects may be mediated by arginine vasopressin (AVP) receptors on osteoclasts and osteoblasts. Further, even mild hyponatremia can contribute to neurological dysfunction via gait instability and increased falls, bot...

A 6-hour octreotide suppression test (OST) is useful in the selection of patients with acromegaly for chronic somatostatin depot analogues treatment. However, it is time consuming and that brings inconvenience to patients. We aim to simplify the blood sampling of OST, and determine the reliability of a short version of the classic 6-hour OST. The data provided in the supplementary tables of the primary manuscript were used to re-analyze the efficacies of the simplified OST tes...

Objective: The distinction between constitutional delay of growth and puberty (CDGP) and congenital hypogonadotropic hypogonadism (CHH) in males with delayed puberty is difficult but important for timely treatment. We aimed to summarize the sensitivity and specificity of serum inhibin B (INHB) level in distinguishing CHH with CDGPin boys.Methods: Studies in the PubMed, EMBASE and Cochrane Library databases were systematically searched from the date of da...

Objectives: BRAFV600E- anaplastic thyroid cancers (ATCs) show remarkable responses to dabrafenib and trametinib (dab/tram) an effect that may be in part immune-mediated. Murine BRAFV600E-ATCs regress upon BRAF inhibition. We find that recurrences are frequent and associated with loss of Mhc class II (MhcII) expression. Our goal was to investigate the mechanisms of loss of antigen presentation by tumor cells and whether this contributes to disease recurren...

Context: Postoperative central diabetes insipidus (PDI) is one of the most common complications of surgical treatment of pituitary adenoma, temporary or permanant. The diagnosis of PDI was suspicious in some occasions and inappropriate prescription of antidiuretic hormone was harmful. Generally, high level serum uric acid (HUA) was a clue for central diabetes insipidus, but we did not know its role for the brain postoperative subjects. As we know, the food intake and health co...

Graves’ orbitopathy (GO) development or reactivation is a well-recognised complication of radioactive iodine (RAI), with possible lower incidence in a recent series. We performed a retrospective audit of Graves’ disease patients treated with RAI at our centre over a 5-year period. We recorded the GO incidence after RAI treatment, risk factors present, and steroid prophylaxis use. Data collected: smoking status, thyroid-stimulating hormone receptor antibody (TRAb), GO...

The defining feature of endometriosis is that endometrial tissues are deposited and grown onto sites outside of the uterine cavity. The pathogenesis of endometriosis, however, remains controversial despite extensive research. Since the endometriosis has been known as an estrogen-dependent inflammatory disease, the alterations in estrogen-mediated cellular signaling play an essential role in the pathogenesis of endometriosis. In addition to higher estrogen receptor (ER)β l...

Introduction: Resolution of pituitary tumour without surgical intervention is rare. The mechanism of spontaneous resolution of pituitary adenoma is unclear but may be explained by either pituitary apoplexy or hypophysitis responding to steroids. Bray BP, et al(2021) reported the case of vanishing pituitary mass due pituitary apoplexy. Park SM, et al (2014) reported 22 cases of pituitary mass due hypophysititis which improved mostly with medical therapy.C...

Initial Presentation (February 2018) A 54 years old Chinese male attended the Emergency Department of a public hospital in February 2018 for psychotic symptoms of 1-month duration. He has a past medical history of bifrontal craniotomy 20 years ago for brain tumour. A computed tomography scan of the head was performed which showed increased pituitary fossa and suprasellar space soft tissue. A pituitary hormone panel was performed [Table 1]. He was diagno...