Endocrine Abstracts

Introduction: Hypercalcaemia is a relatively common medical condition affecting around 1% of the general population. Around 90% of the cases are due to either primary hyperparathyroidism (PHPT) or malignancy. Familial hypocalciuric hypercalcaemia (fHH) is a rare autosomal dominant condition that can result in hypercalcaemia. It has an estimated prevalence of1 in 78 000. In most of the cases, fHH is due to a mutation in the calcium-sensing receptor gene (CaSR). Other rare cases...

Introduction: Endocrine late effects can manifest in hemopoietic stem cell transplantation survivors who were exposed to myelosuppressive conditioning treatment. These include dysfunction of the hypothalamic/pituitary, thyroid, and gonads leading to premature ovarian insufficiency and primary amenorrhoea. In addition, metabolic dysregulation and increased risk of diabetes have been observed in these patients. The investigation for primary amenorrhoea in this condition can rare...

Adolescence is specific periods with physical, physiological, behavioral and social changes. Dietary intakes and food habits are important factors in determining those well-balanced changes during this period of life).336 high school girls (168 urban and 168 rural) in 14–18 years old were randomly selected to determine their daily dietary patterns, in comparing the differences between rural and urban adolescent girls.Data were...

Introduction: Prolonged hypoaldosteronism is an uncommon complication following unilateral adrenalectomy for primary aldosteronism. There are only 5 case reports in literature. However, a retrospective series involving 110 patients found that it occurred in 5% of patients. We present our experience with two patients.Case presentation: Patient 1 was a 51-year-old male presenting with a 7-year history of difficult-to-manage hypertension. He was intolerant ...

Adrenal tumors are not uncommon in endocrine practice. We collected retrospective data from our clinical records of our patients with adrenal tumors from 2021 January to 2023 January. There were a total 20 patients; males 10 (50%) and females 10 (50%). Mean age was 47.4±10.65 years and average BMI was 26.57±4.94. Hypertension was seen in 13 patients (65%) and diabetes in 9 patients (45%). Nonfunctioning adrenal adenomas (NFAAs) were seen in 12 patients (60%) and function...

Pituitary tumors are infrequently seen in an endocrine practice. We collected retrospective data from our clinical records of our patients with pituitary tumors from January 2018 to December 2023. There were a total 31 patients; males 9 (29.03%) and females 22 (70.97%). Mean age was 38.54±12.37 years and average BMI was 26.10±3.91. Headache and visual problem was the most common symptom in 13 (41.9%) patients each followed by menstrual irregularity in 8 (25.80%) patients...

Introduction: Nelson’s syndrome is a significant long-term complication of bilateral adrenalectomy for Cushing’s disease. However, evidence about possible factors that can predict its occurrence, is controversial and limited.Objective: The objective of this analysis was to elucidate the role of various factors in prediction of Nelson’s syndrome and the extent of their modifying effect.Methods: All patients with Cushi...

Aim: To determine the HbA1c cut-offs for diagnosis of prediabetes based on isolated IFG, isolated IGT and both IFG and IGT.Methods: Cross-sectional randomized population survey involving 2368 adults, aged ≥20 years. HbA1c was measured on a Bio-Rad 10 system in 1972 subjects.Results: Among 1972 studied subjects, 329 were detected to have prediabetes based on isolated IFG in 125 (6.3%), isolated IGT in 141 (7.1%) and both in 63...

In Ireland, we are devolving management of diabetes to primary care. Recent studies highlight the importance of early glycemic (metabolic memory) & multifactorial control. Our hospital‘new’patient waiting lists average 18 months and for ‘best practice’, this is “time lost”. We established a pilot program for a rapid assessment to reduce waiting times and ensure specialist input. This is a retrospective review of our 50 patients thus far. 30% w...

Introduction: The uncertainty surrounding the optimal dose to rectify severe vitamin D deficiency (VDD) necessitates further investigation.Aim: To review and analyze various vitamin D (VD) supplementation doses, durations, and their effects on 25-hydroxyvitamin D (25OHD) levels, along with their biochemical and clinical outcomes, in the management of VDD.Methods: We reviewed intervention studies targeting VDD from databases (PubMed...