Endocrine Abstracts

Introduction: Polycystic ovary syndrome is a very heterogeneous disease. Clinical and para clinical findings in such patients varies from one patient to another.Aim: The aim of our work is to study the clinical and para clinical profile of PCOS.Methods: This is a retrospective descriptive study of patients with PCOS followed in the endocrinology department of Hedi Chaker University Hospital of Sfax, Tunisia. PCOS +was diagnosed bas...

Introduction: Polycystic ovary syndrome is a pathology increasingly observed in women of childbearing age, in whom changes in hormonal and metabolic balance have been recordedAim: The aim of our work is to find Correlations between metabolic and hormonal parameters in PCOS patientsMethods: This is a retrospective descriptive and analytic study of patients with PCOS followed in the endocrinology department of Hedi Chaker University ...

Introduction: The corticosurrenaloma is a rare malignant adrenal tumor with an unfavorable prognosis. The 5-year survival rate at stage IV, defined by the presence of distant secondary locations, does not exceed 28%. We report the case of a patient followed in our department for stage IV corticosurrenaloma and the challenges encountered during her managementCase report : Ms. H, a 42-year-old patient, is under our care for corticosurrenaloma. Her cancer w...

Introduction: COVID-19 caused by SARS-COV-2 infection can lead to multi-organ injuries and significant mortality in severe and critical patients, especially among those individuals with type 2 diabetes. The aim of our study was to assess associations between severe COVID-19 pneumonia and clinical and biological characteristics of patients with type 2 diabetes.Methods: This was a retrospective and descriptive study including 40 Tunisians patients hospital...

Ovarian carcinoma is the most deadly and leading cause of cancer death occurring in the female reproductive tracts. 17β-estradiol (E2) has long been considered as one of the effective causes of ovarian cancer through its actions via estrogen receptors (ERs). In contrast, progesterone (P4) offers protective effect against ovarian carcinogenesis. We predicted that P4 would inhibit the metastasis of BG-1 human epithelial ovarian cancer cells, which was induced by E2. In the ...

The distinct roles of estrogen receptors (ERs) related with androgen receptors (ARs) have been proposed in prostate cancer, while the involvement of transforming growth factor-β (TGF-β) has been reported in prostate cancer progression. We examined that TGF-β signaling pathway is associated with ER signaling in LNCaP prostate cancer cells, which express ERα and ERβ, and ARs. We determined whether the exposure to phthalate may induce the prostate cancer ...

In the present study, we determined whether two endocrine-disrupting chemicals (EDCs), triclosan (TCS) and octylphenol (OP), are able to alter the expression of two cell cycle regulators, cyclin D1 and p21, in both in vitro and in mouse breast cancer models. In addition, we determined whether the stimulatory effects of OP or TCS on breast cancer progression may be associated with an estrogen receptor (ER)-mediated signaling pathway. Altered expressions of cyclin D1 an...

Fenhexamid is one of antifungal agents used in agricultural applications, which are present at measurable amounts in fruits and vegetables. Fenhexamid has been reported to act as an anti-androgen in an androgen receptor reporter assay in engineered human breast cancer cells. Aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor, which translocates into nucleus and dimerizes with aryl hydrocarbon receptor nuclear translocator (ARNT). Although function of AR...

Introduction: Fasting during Ramadan is an obligatory practice for adult Muslims. Although exemptions exist in certain conditions,including diabetes, the majority of diabetic patients fast despite this concession with the risk of complications mainly hypoglycemic accidents. The aim of this study is to establish the relationship between hypoglycemic accidents and drug treatment, therapeutic education, clinical and biological characteristics of tunisian diabetic patients during ...

ObjectiveThe study’s purpose is to describe the therapeutic management of papillary thyroid microcarcinoma.Material and methodsThis is a retrospective study including 55 cases of papillary thyroid microcarcinoma treated at our department, from 2000 to 2020.ResultsOur study included 8 men and 47 women. The mean age was 48.64 years with extreme ages from 24 to ...