Endocrine Abstracts

Introduction: Prostate cancer is a neoplasm with high incidence and prevalence in the elderly population in western countries. Androgen deprivation therapy (ADT) has been used in locally advanced or metastatic disease, although most relapse, becoming hormone resistant, which is a poor prognostic event.Objectives: The aim of this study was to evaluate the association of genetic polymorphisms NOS2, GPRC6A, VKORC1, ARGI and ARGII in prostate cancer, particu...

Background: Hypoglycemia is an important side effect in pharmacotherapy of patients with diabetes mellitus. Medical organizations have tried to define hypoglycemia in clinical practice and RCTs with scientific statements and guidelines.Objective: To explore the method of reporting hypoglycemia conducted on SGLT-2 inhibitor RCTs.Methods: A systematic review using PubMed to find data on RCTs conducted for SGLT-2 inhibitors, limited t...

Cushing’s disease is the main cause of endogenous hypercortisolism. Comorbidities increase morbidity and mortality and the treatment is fundamentally surgical. Patients may use drugs to lower hypercortisolism as pre-surgical preparation and post-surgical treatment when cure is not reached.Objective: Evaluate the benefits and collateral effects of ketoconazole in Cushing’s disease.Methods: In 22 patients with Cushing’...

Paraganglioma (PGL) are rare neuroendocrine tumors with an estimated prevalence of 1:6500, with cardiac PGL being even rarer. Although most PGL are benign, approximately 15–35% of PGLs have metastatic disease, with few effective treatment options. Novel therapeutic indications, such as 177Lu-DOTA-TATE for patients with PGL, has been investigated in several clinical trials. A 66-year-old woman was referred to Cardiology in 2011 due to an incidentaloma adjacent to the right...

Introduction: Radiotherapy (RT) has been proven to be effective in controlling hormone production and tumor growth in pituitary adenomas (PA). Still, RT adverse effects had turned it an unattractive choice of treatment. The aim of this study was to evaluate the efficacy and safety of RT for patients with PA.Methods: We conducted a retrospective study of patients treated in our center, a central hospital, since 1998. Thirty-three patients were included, 6...

IntroductionPituitary apoplexy (PA) consists of acute infarction/hemorrhage of the gland, involving mostly a previously unrecognized adenoma. One of its most documented precipitating factors is anticoagulation in the context of acute coronary syndrome treatment. To our knowledge only one report described a PA secondary to anticoagulation for pulmonary thromboembolism.Case reportA 75-year-old men with known hy...

Multiple benign symmetric lipomatosis (Madelung’s disease, Launois–Bensaude syndrome) is significantly rare disease characterised by symmetrical focal deposition of adipose tissue in the neck, upper part of the arms, back, pelvis, and thigh. Although its etiology is uncertain, it has been associated with genetic factors, mitochondrial inheritance and alcoholism. Its pathogenesis seems to include a dysfunction of cAMP and levels of catecholamines in adipocytes. This c...

Introduction: The differential diagnosis of overgrowth includes constitutional tall stature, excess growth hormone (GH) and genetic syndromes. Sotos syndrome generally presents with overgrowth, dysmorphisms and early learning disabilities. Here in, we describe the diagnostic pathway of Sotos Syndrome in an adult male presenting with tall stature and mild morphological and cognitive features, prompted by his son’s clear manifestation of the classic triad.<p class="abst...

Introduction: XX male syndrome is a disorder of sex development associated with a 46, XX karyotype and is characterized by such features as: small testes, hypergonadotropic hypogonadism, male external genitalia, gynecomastia and azoospermia. The estimated prevalence is 1/20.000 males. Gender role and gender identity are reported as male. Identification and subsequent treatment is necessary to avoid the manifestations of testosterone deficiency.Clinical C...

Background: Clinically non-functioning pituitary adenomas (NFPAs) are among the most common pituitary lesions. Its management includes surgery, radiation or observation. The authors aim to compare clinical characteristics and outcomes between patients submitted to surgery or expectant observation (EO).Methods: Retrospective review of medical records from 1996 to 2016. In our centre, there is only 1 pituitary surgeon and NFPAs patients are referred to sur...