Endocrine Abstracts

Introduction: Inflammation has been involved in the physiopathology of diabetic ketoacidosis (DKA). Hematological inflammatory markers such as neutrophil-to-lymphocyte ratio (NLR) and white blood cell count (WBC) can serve as predictive markers for a systemic inflammatory response. This study aimed to evaluate hematological inflammatory markers in T1DM patients with DKA and without-DKA in an uninfected state and to determine their role in the prediction of DKA.<p class="ab...

A 60-year-old engineer was reviewed in the Endocrinology clinic on 07/05/2021. He reported weight loss, palpitations, disturbed sleep, and fatigue over the previous four (4) months. He denied any neck pain or swelling. There were no symptoms consistent with thyroid eye disease. He had no pre-existing history of thyroid disease. TFT’s in March 2021 confirmed primary hyperthyroidism (TSH < 0.004 (0.35- 4.94 miu/l), FT4 19.8 (9-19 pmol/l), FT3 7.4 (2.9- 4.9 pmol/...

Case History: A 56-year-old woman initially sought evaluation at an endocrine clinic in 2018 due to the discovery of an adrenal incidentaloma (AI). She complained of chest pain and underwent coronary computed tomography angiography, which revealed no significant coronary artery disease but incidentally detected a lung nodule. Subsequent interval assessment of the lung nodule via HRCT unveiled a well-defined 25 × 20 mm left adrenal mass. Further examination indicated a 30 ...

Introduction: In addition to its role in phosphocalcic metabolism, the vitamin D (vitD) seems to have anti-tumor effects, particularly in colorectal cancer (CRC). The active metabolite of vitD [1,25(OH)2D3], converted by the enzyme CYP27B1, inhibits proliferation and promotes differentiation of CRC cells which express vitamin D receptor (VDR) via the regulation of a high number of genes. The vitD metabolism seems also to regulate inflammatory processes in...

A 28-year-old female presented to ED with one week history of flu-like symptoms, palpitations, increasing breathlessness, and productive cough with copious sputum, of two days duration. There was h/o some weight loss over the last year, with episodic palpitations over the last 8-10 years that increased in frequency over the last one year. She had a family history of hyperthyroidism paternally and maternally. On examination, there was mild lid-lag and proptosis. She was tachypn...

Introduction: Statins are widely used to prevent cardiovascular diseases. Nonetheless, reducing cholesterol, the main substrate for steroidogenesis, may impair cortisol production. The aim of our study was to assess the effect of high dose statin therapy on cortisol and dehydroepiandrosterone-sulphate (DHEA-S) levels in type 2 diabetes male patients.Methods: This was a single-center, prospective study, during the period march 2021 - July 2022, including ...

Introduction: Statins are widely used in primary and secondary cardiovascular prevention. They have been described to improve renal function. We aimed in this study to evaluate the effect of high dose atorvastatin therapy on renal outcome in type 2 diabetes patients.Methods: This was a single-center, prospective study, including 60 men with type 2 diabetes mellitus, aged between 40 and 65 years, statin-free, in whom the indication of a high dose statin t...

IntroductionHomeostasis model assessment for insulin resistance (HOMA-IR) is widely used as a marker of insulin resistance. However, it reminds an expensive maker requiring insulin dosage. Several studies tried to found simple alternative predictors of insulin resistance such as triglycerides to HDL-C ratio with conflicting reported findings. The aim of our study was to investigate the usefulness of the atherogenic index of plasma (AIP) and the visceral ...

We aimed to identify causal mutation(s) in 2 patients (P1 and P2) with thyroid dyshormonogenesis (TD) from a consanguineous Tunisian family. Patient P1 developed TD at age 10; while P2 developed it at a late age (30 years) with no goiter. Scintigraphy showed homogeneous uptake of 131I in P1 patient. Genetic analysis was performed using candidate gene approach. Thus, sequencing of the 17 exons of the TPO gene revealed only presence of rs4927611 polymorphism ...

Introduction: Cardiovascular diseases are frequent in patients with hypopituitarism receiving conventional hormone replacement therapy. They represent the main cause of premature death in this population. Emerging evidence smggests that beyond traditional risk factors, evaluating coronary calcium score (CCS) and inflammatory markers such as high-sensitivity C-reactive protein (hs-CRP) provides valuable insights into cardiovascular health in this population. The aims of the pre...