Endocrine Abstracts

Purpose: Congenital leptin deficiency (CLD) is an extremely rare condition. The effects of the disease and leptin treatment on ocular structures are unknown in this patient group. In our study, we planned to compare the ocular findings of patients who received leptin replacement therapy due to leptin deficiency with the control groupMethods: In this prospective, cross-sectional comparative study, six patients with a diagnosis of congenital leptin deficie...

Introduction: Ornithine transcarbamylase deficiency (OTCD) is a urea cycle disorder that causes the accumulation of ammonia, which can lead to neurocognitive problems in patients1. Here we report a 21-year-old man who was diagnosed with OTCD during investigation for secondary osteoporosis.Case: The patient applied to the Endocrinology department complaining of widespread muscle-joint pain, shortening in height, nausea/vomiting attacks followed...

Introduction: Parathyroid carcinoma is a rare malignancy of the parathyroid glands. Parathyroid carcinoma may be suspected, but it usually cannot be confirmed prior to operation.Case: A 35-year-old male was consulted to Endocrinology department with persistant kidney stones. He was operated five times in 10 years for recurrent kidney stones.His lab results are as follows; Ca:13(8.8–10.6), P:2.2 mg/dl(2.5–4.5), ALP:84U/L(3...

Large scale clinical studies and meta-analysis suggest that treatment with angiotensin receptor blockers (ARBs) and angiotensin converting enzyme inhibitors (ACEIs) could have protective effect against diabetes development. While diuretics and β-blockers have some well known adverse effect on glycaemic regulation, ARBs/ACEIs’ effect on glucose regulation in patients already diagnosed with diabetes has not been investigated well enough. Also to the best of our knowled...

Diabetes is one of the risk factors for Achilles tendon rupture. Tendon thickening and impaired collagen organization have been reported in diabetic patients in small studies. In this report, we present the rupture of the Achilles tendon in a female patient with poorly controlled diabetes mellitus and diabetic neuropathy. A 52-years-old woman with a medical history of diabetes treated by intensive insulin therapy, developed pain in the right heel without previous trauma. The p...

Introduction: Autoimmune Polyglandular Syndrome (APS) is a very rare endocrinopaty, characterized by the coexistence of at least two glandular autoimmune mediated diseases. In this case a patient presented with hyperpigmentation of the whole body, significant weight loss for last 6 months.Case: A-49 year old male were refered to our deparment with loss of appetite, fatigue, nausea, weight loss and with marked buccal pigmentation. Blood pressure was 80/50...

Sarcoidosis is a multisystem granulomatous disease of unknown cause. The prevalence of neurosarcoidosis is about 5–15%. Hypothalamo-pituitary sarcoidosis is even rarer (<1% of cases evaluated for sellar and stalk lesions).Case Report: A 33-year-old man presented to urology department with erectile dysfunction which started six months ago. Hormonal evaluation revealed gonadotropin deficiency and hyperprolactinemia (Total testosterone: 30.5 ng/dl,...

Introduction: The risk of malignancy has often been reported to be more frequent in Graves’ disease (GD) than non-autoimmune thyroid nodules. However, frequency of thyroid nodules, diagnostic yield of fine-needle aspiration (FNA), and their potential for bearing malignancy in GD are still debatable issues. We aimed to determine the prevalence, ultrasonographic and cytological features, and the rate of malignancy outcome of thyroid nodules in a group of patients with GD.</...

Riedel thyroiditis (RT) is a rarest form of thyroiditis, and characterized by dense fibrosis of the throid gland and infiltration into surrounding tissues. RT generally presents with local symptoms association with compression and also fibrotic process can impact thyroid and parathyroid functions. We report a case with RT which presents with compression findings and also hypoparathyroidism and hypothyroidism. 30 year old women visited our outpatient clinic with a complaint of ...

INTRODUCTIONThe plasma concentrations and urinary excretion rates of 18-OH-F and 18-oxo-F are high in Conn's syndrome and glucocorticoid suppressible hyperaldosteronism, reputedly because aldosterone synthase (AS) has abnormal access to cortisol (F). However, both compounds are also excreted in normal subjects. Two enzymes, 11beta-hydroxylase (11OH) and AS, located in the zona fasiculata (ZF) and zona glomerulosa (ZG) respectively, are capable of 18-hydroxylation but only ...