Endocrine Abstracts

Background: Insulin, derived from a single chain precursor pro-insulin, is cleaved by convertases to form insulin (t1/2 – 4 min) and C-peptide (t1/2 – 30 min). The ratio of insulin to C-peptide levels, which is usually less than one, is reversed in presence of exogenous insulin and insulin autoimmune syndrome. We present the significance of insulin-C-peptide ratio (ICR) in the diagnostic algorithm for the investigation of endogenous hyperinsulinaemia.<p class="ab...

Back ground: Radio iodine treatment is widely used in the management of hyperthyroidism. Recent guidelines have stressed the importance of advising patients of the recommendations with regard to radiation protection, and the implications of radioiodine treatment in relation to work, travel and contact with the family. We carried out a survey to assess our joint radioiodine clinic approach where all patients referred for treatment are assessed jointly by a consultant endocrinol...

Neuroendocrine neoplasms (NENs) are rare but diverse group of malignancies that can arise from gastroenteropancreatic tract and lungs. NENs can be clinically symptomatic (functioning) or silent (non-functioning). We present a case found to have multiple NENs in the absence of known clinical syndrome and discuss role of genetic testing versus clinical screening. 54 Female, referred to endocrine team for investigation of hypoglycaemic symptoms and suspected insulinoma. Routine b...

Introduction: Syndrome of inappropriate antidiuretic hormone secretion(SIADH) is frequently encountered in clinical settings. Hyponatraemia is often seen in cancer and correlates with poor prognosis. It can rarely precede cancer diagnosis. We present a case series of two patients with idiopathic SIADH, who developed terminal malignancy later in life.Case 1: A 59-year-old female presented in 2016 with seizure due to severe euvolemic hyponatraemia Na103 mo...

In this study, effects of bovine somatotropin on libido, serum testosterone, hematological indices and certain serum biochemical metabolites in Sahiwal bulls were investigated. Six adult Sahiwal bulls with clinically normal reproductive tract and kept at the Semen Production Unit, Qadirabad, Sahiwal, Pakistan were used. These bulls were divided into two equal groups, i.e. treatment and control. Bulls of the treatment group were given bovine somatotropin (bST) at of 500 mg week...

Introduction: We report a rare case of hyperandrogenism associated with portal hypertension as a result of Alagille syndrome.Case report: 21-yr old female presented with primary amenorrhoea and mild hirsutism. There was no history of delayed puberty or acne. Past medical history: Alagille syndrome (biliary tree hypoplasia, liver disease, portal hypertension, splenomegaly, Barrett’s oesophagus and pulmonary stenosis). Drug ...

Introduction: We report a rare case of hyperandrogenism associated with portal hypertension as a result of Alagille syndrome.Case report: 21-yr old female presented with primary amenorrhoea and mild hirsutism. There was no history of delayed puberty or acne. Past medical history: Alagille syndrome (biliary tree hypoplasia, liver disease, portal hypertension, splenomegaly, Barrett’s oesophagus and pulmonary stenosis). Drug ...

Introduction: Hypoparathyroidism may be an isolated or a component of a complex syndrome. Although genetic disorders are not the most common cause, molecular analyses have identified a growing number of genes that when defective result in impaired formation of the parathyroid glands, disordered synthesis or secretion of parathyroid hormone.Case presentation: We are reporting a 37-year-old gentleman, who is the first adult case diagnosed at our University...

Background: In the UK, 1 to 4 per 1000 people have primary hyperparathyroidism (PHPT) and are at risk of hypercalcaemia and its complications. Whilst surgery is the only curative option in the management of PHPT, several patients are managed conservatively or medically. Cinacalcet (a calcimimetic) has a role in PHPT management, in those who have declined or are unable to progress to surgery. It is important that the use of Cinacalcet in these cases adheres to ...

Introduction: Immunotherapy has transformed the outcomes of various cancers. Monoclonal antibodies against cytotoxic T lymphocyte antigen 4 (CTLA4), programmed cell death 1 (PD1) and its ligand, PDL1 target mainly T cells, unleashing the immune system against tumour cells. Immune checkpoint inhibitor therapy results in a variety of immune related adverse events, including various endocrinopathies. Thyroid disorders, pituitary disorders are relatively more common compared to pr...