Endocrine Abstracts

Background: Effects of vitamin D on immune cells might affect diabetes mellitus (DM) development since inflammatory factors have been linked to insulin resistance (IR). The aim of this study was to investigate the effect of cholesterol treatment on insulin sensitivity metabolic markers in patients with chronic autoimmune thyroiditis.Materials and methods: In this double-blind, randomized, placebo-controlled trial, which was conducted from May to Septembe...

Diabetes mellitus is a risk factor for cancer, specifically of breast, endometrium, bladder, liver, colorectum, and pancreas. The pathophysiology of how diabetes contributes to cancer growth or development is an area of active investigation. The aims is to study the frequency and morphological features of thyroid cancer in patients with type 2 diabetes mellitus (DM).Materials and methods: The study involved 45 patients with thyroid cancer and type 2 DM. ...

Objective: This study analyzes impairments occurred in local thyroid hormones metabolism and their connection to decreased glucose uptake, amyloid-β accumulation and apoptosis of neurons in pharmacologically induced animal model of Alzheimer’s disease.Methods: Spectrophotometry, immunoassay, morphological studies including immunohistochemistry, rat Scopolamine-induced Alzheimer’s disease model (WAG male rats).Results...

Introduction: Diabetes mellitus is the most common disease of the 21st century. The main challenge for modern doctors is to prevent its development.Purpose: Study the state of carbohydrate metabolism in individuals with different obesity phenotypes.Materials and methods: We examined 96 individuals (18-64 y.) according to each obesity phenotype during 2019 - 2021 on the basis of the Vinnitsa Regional Clinical High-Specialized Endocr...

Objective: To determine the peculiarity of melatonin (M) at women with polycystic ovary syndrome (PCOS).Methods: Fifty-six women with PCOS from 18 to 29 years old have been included in research. Control group 22 healthy women with regular menses, same age. Levels M were determined in the blood at 2 and 8 o’clock in the morning on a fifth day menstrual cycle in January and July.Results: It is established, that the level of M in...

Purpose: Bariatric surgery is very efficacious in treating severe obesity. However, its effect of menstruation and ovulation is currently unknown. The purpose of this study was to assess the effect of gastric sleeve resection (GSR) on menstrual pattern in women with stage III-IV obesity and ovulatory dysfunction compared with conventional management.Methods: This was a prospective, multicentre, non-randomized trial, in premenopausal women, who fulfilled ...

Purpose: Thyroid cancer (TC) is the most common endocrine cancer worldwide, affecting mainly women of the reproductive age. However, no data exist with regard to its association with endometrial or uterine disorders. The aim of this study was to assess the risk of hyperproliferative pathology of the reproductive system in female TC survivors.Methods: This was a cross-sectional study in female patients, aged 20-45 years, diagnosed with papillary TC (PTC) ...

Introduction: To date, there was evidence for an association between lower serum 25(OH)D levels and higher prevalence of obesity in individuals with type 2 diabetes mellitus (DM). Vitamin D status is inversely associated with the prevalence of obesity in patients with insulin resistance syndrome. Actually, no study that has been specifically performed to investigate the association between vitamin D levels and all the parameters of body composition in obese males with type 2 D...

Introduction: Acromegaly (ACRO) is a rare disease of an excessive somatic growth and distorted proportions arising from hypersecretion of growth hormone (GH) and insulin-like growth factor-1 (IGF-1). The aim Of this study is to investigate basic demographic parameters such as the age and gender related features, age at diagnosis of the disease, its clinical manifestations, biochemical control and structure of complications in Ukrainian patients with ACRO in a single neuroendoc...

Introduction: The beneficial interaction between the microbiota and humans is the way how bacteria contained within the gut ‘talk’ to the immune system. Into this landscape probiotics and nutraceuticals play a major role. The study aims to determine whether probiotics plus nutraceuticals such as smectite or omega-3 are superior to probiotic alone on the monosodium glutamate (MSG) induced obesity model in rats.Methods: Totally 7...