Endocrine Abstracts

Aims: There are few data comparing oxidative stress markers in CSII versus MDI/G We compared after randomization CSII (Continuous subcutaneous insulin infusion) vs MDI/G therapy (multiple doses of insulin with glargine) in DM1 people previously optimized at MDI/G being the primary objective assessment of metabolic control and oxidative stress.Assess oxidative stress and metabolic control in patients with type 1 diabetes (T1D) after randomization in CSII ...

Background and objective: Several trials showed that sensor-augmented pump (SAP) therapy is safe and effective to reduce hypoglycemic events and improve glicemic control with high treatment satisfaction. Nevertheless patient adherence and sensor use in trials usually decrease with time. Our objective was to evaluate metabolic control and adherence and sensor use after initiation of SAP in a clinical trial.Methods: In 2008 we recruited 25 patients in trea...

Background and aims: INSmutations can cause INS-MODy and have been described more frequently in cases of neonatal diabetes mellitus. The reported phenotypic expression of INS-MODy is quite variable.Objective: To clinically, biochemically and molecularly characterize INS-MODy patients in two Spanish tertiary level hospitals during the period 2009-2023.Methods: Cross-sectional study that included 121 pediatric patients with ...

Objective: Our objective in this study was to identify the type of clinical care received by young type 1 diabetic patients who have made the transition from paediatric to adult care, and to assess the metabolic status of the patients. The research aimed to develop a sustainable and coordinated approach to facilitating the transition between diabetes services for adolescents and reveal from the perspective of the adolescents living with type 1 diabetes their experiences surrou...

Introduction and Objectives: Although Next Generation Sequencing (NGS) technologies have significantly improved the molecular diagnosis of MODy, there is still a high percentage of cases in which the clinical suspicion remains without confirmatory molecular diagnosis. The main objective was to identify new candidate genes for MODy, by means of targeted NGS of a cohort of adult patients with clinically suspected MODy, in whom variants in the 14 known MODy genes implicated in it...

Background: There aren’t published randomized studies comparing the clinical impact of degludec and Glragina U300 in the treatment of type 1 diabetes patients. (T1DP)Objective: To compare efficacy and safety of the new long acting analogues Glargine U 300 and Degludec in 300 Type1 diabetes patients treated with basal/bolus treatment.(BBT)Material and methods: Randomized control study 1.1 in 300 T1DP treated with BBT with glarg...

Objective: Prospective observational study in a group of pregnant patients affected by type 1 diabetes (T1DM), that are monitored by the Endocrinology and Pregnancy Unit.Material and Methods: Weevaluated 12 pregnant patients with T1DM in which a FreeStyle Libre Flash Glucose Monitoring Systemwas installed, in addition to their capillary glucose self-control (SMBG), over the past year 2019. Time above range (TAR), time in range (TIR) and time below range ...

Introduction: Latent Autoimmune Diabetes in Adults (LADA) is a form of diabetes which is underdiagnosed and appears to have characteristics of both type 1 (autoimmune in nature) and type 2 diabetes (adult age at onset and initial response to oral hypoglycemic agents).Objective: To study features of patients with LADA diagnosed and treated in our clinic.Material and methods: Retrospective study of patients attended in our clinic in ...

The 46 XX male syndrome (de la Chapelle syndrome or 46,XX testicular disorder of sex development -46,XX testicular DSD-) is a rare phenotype associated with disorder of the sex chromosomes. XX males exist in different clinical categories with ambiguous genitalia or partially to fully mature male genitalia, in combination with complete or incomplete masculinization.Clinical report: We describe the clinical, molecular, and cytogenetic findings of a 26-year...

Objective: To report a case of hyperandrogenism attributable to the presence of an ovarian Leydig cell tumor secreting testosterone in a postmenopausal woman.Methods: The laboratory, radiologic, and pathologic findings in our case are described.Results: A 59-year-old woman presented with a history of gradual increase in facial and body hair, scalp hair loss, male pattern baldness, and deepening of her voice, beginning 5–6 year...