Searchable abstracts of presentations at key conferences in endocrinology

ea0032s9.2 | New data treatment of hyperglycemia | ECE2013

Early insulin treatment in type 2 diabetes

Nilsson Peter M

The evidence base for starting early insulin treatment in patients with type 2 diabetes is rather scanty. In the UKPDS trial the intensive treatment of hyperglycaemia in newly detected patients with type 2 diabetes based on insulin or sulponylurea (no separation possible) revealed a significant reduction of myocardial infarction risk (15%, P=0.01), but only after prolonged post-study follow-up after 10 years1. In 2012 the ORIGIN study was published showing ...

ea0002p81 | Signalling | SFE2001

Demonstration of functional vascular estrogen receptor beta

#B-O|#Nilsson|#

Estrogen protects women from cardiovascular disease through an unknown mechanism. Two subtypes of estrogen receptors (ERalfa and beta)have been isolated and cloned. We have demonstrated abundant vascular expression of ERbeta in female rats and mice using immunocytochemistry. A majority of endothelial and vascular smooth muscle cell nuclei in various segments of the vascular tree showed immunoreactivity towards ERbeta. Activation of vascular ERbeta with the selective ERbeta ago...

ea0070oc5.7 | Thyroid | ECE2020

Triiodothyronine (T3) use in hypothyroidism and effects on cancer and mortality

Planck Tereza , Hedberg Fredric , Calissendorff Jan , Nilsson Anton

Background: The prescription of triiodothyronine (T3) for hypothyroidism is increasing worldwide, however, long-term effects of its use are largely unknown. Previous studies have suggested possible association between T3 use and breast cancer. The aim of the study was to examine the effects of T3 use on cancer incidence and mortality.Material: Our sample included the full adult population of individuals living in Sweden with at least three purchases of t...

ea0016s5.1 | Protein modifications - proteomics | ECE2008

Comparative proteomics as a tool in biology: the protein microscope

van der Post Sjoerd , Hakansson Joakim , Enerback Sven , Nilsson Tommy

We use redundant peptide counting as a tool to compare, quantitatively, data from mass spectrometry analyses. When combined with hierarchical clustering, a tool commonly used for micro array analysis, we can group proteins based on their relative abundance across samples. In this way, we recently completed a spatial map of the secretory pathway of rat hepatic cells comprising some 1400 different proteins, each with a defined distribution (Gilchrist, Au, Hiding et al. 20...

ea0032p625 | Growth hormome IGF axis – basic | ECE2013

SNPs within the GH signaling pathway are associated with the fast, but not the long term, IGF1 response to GH replacement therapy in GH deficient adults

Glad Camilla , de Jesus Litenski Barbosa Edna , Filipsson Nystrom Helena , Carlsson Ekander Lena , Nilsson Staffan , Nilsson Anna , Svensson Per-Arne , Johannsson Gudmundur

Introduction: GH deficiency (GHD) in adults is associated with low serum levels of insulin-like growth factor 1 (IGF1) and a deteriorated cardio-metabolic profile. GH replacement therapy (GHRT) increases serum IGF1, an important mediator of the treatment response and safety marker of dose titration. The interindividual variation in treatment response is large and most likely influenced by genetic factors.Aim: The aim of this study was to test the hypothe...

ea0081rc12.2 | Rapid Communications 12: Reproductive and Developmental Endocrinology | ECE2022

Proteomic changes in response to electrical stimulations in skeletal muscle of women with PCOS

Eriksson Gustaw , Nilsson Emma , Boi Roberto , Nystrom Jenny , Stener-Victorin Elisabet , Benrick Anna

Polycystic ovary syndrome (PCOS) is an endocrine and metabolic disorder affecting women of reproductive age. The main features of PCOS are hyperandrogenism and reproductive and metabolic dysfunctions. We have previously shown that muscle contractions induced by either electrical stimulations or exercise act through partially similar signaling pathways in the muscle to induce glucose uptake in the acute response. Long-term electrical stimulations decrease circulating testostero...

ea0090p641 | Diabetes, Obesity, Metabolism and Nutrition | ECE2023

Cancer, cardiovascular disease and all-cause mortality in Iraqi- and Swedish-born individuals in Sweden - the MEDIM cohort study

Fadhel Dhaher Nadine , Pikkemaat Miriam , Shaat Nael , Nilsson Anton , Bennet Louise

Background: Immigrants from the Middle East to Sweden have a twice as high prevalence of type 2 diabetes (T2D) and obesity as native-born Swedes. Both obesity and T2D have been linked to increased incidence of cancer, cardiovascular disease (CVD) and all-cause mortality (ACM); however, data on differences between ethnicities are scarce. Aims: In a population-based cohort we aimed to study the impact of Middle Eastern and European ethnicity on ACM, cancer...

ea0037gp.20.01 | Pituitary – Hypopituitarism | ECE2015

Reduced mortality due to malignant neoplasms in patients receiving long-term GH replacement therapy – a Swedish study based on more than 4000 patient-years

Olsson Daniel S , Nilsson Anna G , Trimpou Penelope , Bengtsson Bengt-AEke , Andersson Eva , Johannsson Gudmundur

Patients with hypopituitarism and untreated growth hormone (GH) deficiency have excess mortality. GH replacement therapy (GHRT) has many beneficial effects, but its impact on mortality has not been proven and there are still safety concerns regarding the potential cancer risk. We have therefore studied the mortality in non-functioning pituitary adenoma (NFPA) patients with and without GHRT. Only patients with NFPA were studied in order to eliminate the influence of the aetiolo...

ea0035n7 | (1) | ECE2014

The Nordic network for endocrine nurses (NNEN).

Forsgren Maria , Wessman Ylva , Nilsson Ann-Sofie , Warn Maria , Backlund Kristina , Guldborg Anette , Follin Cecilia

Background: Previously, the endocrine nurses in Sweden, Denmark, Norway, Finland and Iceland have not been organized. As Endocrine nursing is specialized and no education for a specialist competence in endocrinology is available there is a need for a collaboration to improve the Nordic endocrine nursing.Purpose: The purpose of the Nordic network for endocrine nurses (NNEN) is to enhance the Nordic endocrine nurse knowledge and skills, and also work for a...

ea0029n25 | (1) | ICEECE2012

Primary hyperparathyroidism, vitamin D deficiency and quality of life

Wiveca Aberg , Norenstedt S , Eriksson A , Pernow Y , Saaf M , Nordenstrom J , Zedenius J , Nilsson I-L

Background: The study aimed to evaluate quality-of-life (QoL) aspects and impact of vitamin D deficiency in primary hyperparathyroidism (pHPT).Method: 150 consecutive patients (119 women) with pHPT (mean age 60±11 years; BMI 27±5 kg/m2; ionized calcium 1.44±0.08 mmol/l; PTH 130±69 ng/l) were included. Six weeks postoperatively, the pHPT patients were reexamined and randomized (double-blind) to daily substitution with calciu...