Searchable abstracts of presentations at key conferences in endocrinology

ea0050p394 | Thyroid | SFEBES2017

Investigating the utility of diffusion weighted magnetic resonance Imaging as an adjunct to clinical assessment in Graves’ Orbitopathy (GO)

Feeney Claire , Rahman Farzana , Lingam Ravi , Lee Vickie

Purpose: Early diagnosis and treatment of GravesÂ’ orbitopathy (GO) are essential to prevent physical and psychological burdens of advanced disease. MRI diffusion weighted imaging (DWI) is an emerging modality to assist with timely diagnosis. We investigated the value of DWI in early diagnosis and monitoring and its relationship with the clinical activity score (CAS) and quality of life (QoL) scores in a joint endocrine/ophthalmology clinic.<p class="abst...

ea0050ep103 | Thyroid | SFEBES2017

Severe thyroid-associated orbitopathy manifesting two years post total thyroidectomy for follicular carcinoma variant of the thyroid

Ramli Rozana , Palazzo Fausto , Robinson Stephen , Lee Vickie

We present a case of severe thyroid-associated orbitopathy in a 44-year-old man with metastatic follicular carcinoma of the thyroid. He presented with a neck lump, and following further investigations, underwent a hemithyroidectomy followed by a completion thyroidectomy. Histology of the thyroid confirmed widely invasive follicular carcinoma of Hurthle cell type with foci of vascular invasion (pT3 Nx Mx). He received radioactive iodine ablation therapy (3.7GBq), ...

ea0050oc2.2 | Clinical Highlights | SFEBES2017

Combined immunosuppression & radiotherapy in thyroid eye disease (CIRTED) trial: A multi-centre, double-masked, factorial randomised controlled trial

Taylor Peter , Rajendram Rathie , Uddin Jimmy , Lee Richard , Dayan Colin

On behalf of the Combined immunosuppression & radiotherapy in thyroid eye disease (CIRTED) InvestigatorsBackground: Thyroid eye disease is an inflammatory orbital condition which causes visual dysfunction and psychological morbidity. Current evidence is conflicting on the benefit of radiotherapy and antiproliferative immunosuppression in addition to systemic corticosteroid treatment. In particular, little is known about clinical outcomes mor...

ea0050p394 | Thyroid | SFEBES2017

Investigating the utility of diffusion weighted magnetic resonance Imaging as an adjunct to clinical assessment in Graves’ Orbitopathy (GO)

Feeney Claire , Rahman Farzana , Lingam Ravi , Lee Vickie

Purpose: Early diagnosis and treatment of GravesÂ’ orbitopathy (GO) are essential to prevent physical and psychological burdens of advanced disease. MRI diffusion weighted imaging (DWI) is an emerging modality to assist with timely diagnosis. We investigated the value of DWI in early diagnosis and monitoring and its relationship with the clinical activity score (CAS) and quality of life (QoL) scores in a joint endocrine/ophthalmology clinic.<p class="abst...

ea0050ep103 | Thyroid | SFEBES2017

Severe thyroid-associated orbitopathy manifesting two years post total thyroidectomy for follicular carcinoma variant of the thyroid

Ramli Rozana , Palazzo Fausto , Robinson Stephen , Lee Vickie

We present a case of severe thyroid-associated orbitopathy in a 44-year-old man with metastatic follicular carcinoma of the thyroid. He presented with a neck lump, and following further investigations, underwent a hemithyroidectomy followed by a completion thyroidectomy. Histology of the thyroid confirmed widely invasive follicular carcinoma of Hurthle cell type with foci of vascular invasion (pT3 Nx Mx). He received radioactive iodine ablation therapy (3.7GBq), ...

ea0090p300 | Calcium and Bone | ECE2023

Bioluminescence and autofluorescence of parathyroid glands to identify an intra-thyroidal parathyroid tumour

Lin Zhimin , Wai Kit Lee James , Yuan Ngiam Kee

Bioluminescence is bringing new and exciting possibilities to the field of endocrine surgery, because we are able to better harness the property of autofluorescence of the parathyroid glands. Parathyroid glands have an inherent ability to produce infra-red autofluorescence at the wavelength of 820 nm to 830 nm, if the gland absorbs light at the wavelength of 750 nm. With highly sensitive technology and the ability to filter out other reflected light and noise, it is now possib...

ea0091p2 | Poster Presentations | SFEEU2023

Is it MEN2B or not? That is The Question

Subramaniam Yuvanaa , Lee Jessica , de Benito-Llopis Laura , Sharma Aditi

A 35-year-old gentleman was referred to our Endocrinology department by Moorfields Eye hospital. He reported a one-year history of visual decline in his right eye, which led to prescription glasses, and incidental finding of bilateral conjunctival nodules. He had reduced visual acuity (pinhole right eye: 6/24 and left eye 6/6) and prominent corneal nerves on slit-lamp examination. He underwent an excisional biopsy of the conjunctival nodules confirming bilateral conjunctival n...

ea0065p167 | Metabolism and Obesity | SFEBES2019

Sarcopenic phenotypes are associated with an increased risk of type 2 diabetes: findings from the Korean Genome and Epidemiology Study (KoGES)

Son Jang Won , Lee Won Young , Yoo Soon Jib

The present study aimed to explore the relationship of sarcopenia, with or without the presence of obesity, with the risk of developing type 2 diabetes. We conducted a cross-sectional analysis of 2981 subjects in the Korean Genome and Epidemiology Study. The diabetes status of each subject was determined by using a 75 g oral glucose tolerance test, and body composition was estimated via dual-energy X-ray absorptiometry. The skeletal muscle mass index (SMI, %) was obtained by c...

ea0063p596 | Diabetes, Obesity and Metabolism 2 | ECE2019

The effect of 3 months of daily consumption of sugar-sweetened beverages on liver, adipose tissue, and glucose metabolism in an animal study

Lee Ghayoung , Han Ji Hye , Maeng Hyo Jin , Lim Soo

Background: Growing evidence suggests a link between sugar-sweetened beverages (SSBs) and metabolic disorders. We investigated the effect of SSBs that are commonly consumed by adolescents on glucose metabolism and fatty liver.Methods: We treated 7-week old male C57BL/6 mice with water (control) or either of SSBs: carbonated soda (Coca-Cola®), sweetened milk coffee (Maxwell®), or chocolate-added cocoa (Choco-Latte&#174...

ea0063ep66 | Diabetes, Obesity and Metabolism | ECE2019

Whole-body insulin resistance (WBIR) evolving in four stages and its evolutionary effect on the body weight

Lee Song Jae , Kim Whanwoo , Shin Sang Won

Insulin resistance (IR) may be defined as the physiological condition, in which insulin signaling is somehow deranged somewhat irreversibly such that insulin is of little use to cells or tissues. Specific roles of insulin are quite different in the muscle tissue, adipose tissue, and liver. Accordingly, detailed aspects of IR would be very tissue-specific. Meanwhile, IR may develop first in the muscle tissue with a relatively low cell turnover and then progress, in sequence, to...