Searchable abstracts of presentations at key conferences in endocrinology

ea0041ep861 | Pituitary - Basic | ECE2016

The vasoinhibin solution structure appears unfolded, dynamic, and features aggregation

Triebel Jakob , Schauer Nicole , del Rio Portilla Federico , Aguilar Manuel , Robles Juan-Pablo , de la Escalera Gonzalo Martinez , Clapp Carmen , Bertsch Thomas

Background: Full-length human prolactin (protein data bank identification P01236), the precursor of vasoinhibins, is structurally classified as a class-I helical cytokine with a four-helix bundle core and only a minimal degree of dark regions. Experimental data on the solution structure of vasoinhibins are not available.Methods: A recombinant, human vasoinhibin with a molecular mass of 16.7 kDa, comprising amino acids 29-176 of prolactin, was expressed i...

ea0037ep268 | Calcium and Vitamin D metabolism | ECE2015

Patients with new onset diabetes after liver transplantation have higher sclerostin levels that tend to decrease after an oral glucose tolerance test

Diaz-Guerra Guillermo Martinez , Miguel Gonzalo Allo , Ramos Mercedes Aramendi , Librizzi Soledad , Iglesias Sonsoles Guadalix , Fernandez Elena Garcia , Carranza Federico Hawkins

Introduction: Decreased bone formation has been proposed as a mechanism involved in the higher risk of fractures in diabetic patients. Some clinical studies have found that sclerostin (SCL, a negative regulator of bone formation) is increased in diabetic patients. However, there is no information about the relationship between SCL and new onset diabetes after transplantation (NODAT). The aim of our study is to evaluate serum SCL levels in a cohort of patients with liver transp...

ea0037ep620 | Obesity and cardiovascular endocrinology | ECE2015

Liraglutide improves surfactant protein-B production and reduces right ventricular hypertrophy in a rat model of intersitial pulmonary fibrosis

Gomez Juan Fandino , Perez Marina Romani , Iglesias Veronica Outeirino , Chaves Yolanda Diz , Nunez Maria Gonzalez , Dab Houcine , Gago Eva MariaVigo , Matias Lucas Gonzalez , Ferrer Federico Mallo

Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive and fatal lung disease characterized by excessive matrix deposition that disrupts the normal alveolar architecture and lung physiology. Glucagon-like peptide 1 (GLP1) is a gut-produced hormone with insulinotropic effects. GLP1 receptor is expressed in the lung where it is implicated in the synthesis of the protein (SPs) and lipid fractions of the surfactant. We have previously shown that the GLP1 receptor agonist, l...

ea0037ep867 | Thyroid cancer | ECE2015

The two tyrosine kinase inhibitors, CLM29 and CLM3, have antineoplastic activity in primary cultures from anaplastic thyroid cancer obtained from fine needle aspiration

Ferrari Silvia Martina , Fallahi Poupak , Motta Concettina La , Materazzi Gabriele , Ragusa Francesca , Limongi Francesca , Ruffilli Ilaria , Settimo Federico Da , Miccoli Paolo , Antonelli Alessandro

Anaplastic thyroid cancer (ATC) is one of the most lethal endocrine malignancy, with a mean survival of about 6 months. Until now, the most effective therapy for ATC comprises a multimodal treatment protocol, including surgery, chemotherapy (doxorubicin and cisplatin), and hyperfractionated accelerated external beam radiotherapy, with a median patient survival of 10 months. A possible increase in the effectiveness of the treatment could be achieved testing the sensitivity of &...

ea0037ep868 | Thyroid cancer | ECE2015

Role of miR-26a in follicular thyroid carcinoma

Gentilin Erica , Ortolan Elisa , Gagliano Teresa , Pasquale Carmelina Di , Falletta Simona , Rossi Roberta , Benfini Katiuscia , Tagliati Federico , Uberti Ettore Degli , Zatelli Maria Chiara

Follicular thyroid carcinoma (FTC) is the second most common thyroid malignant epithelial tumor. It is clinically asymptomatic, usually represented by a single nodule, less often multiple, with origin from thyroid follicular epithelial cells. Despite its well-differentiated characteristics, FTC may develop distant metastases through hematogenous dissemination. The molecular alterations involved in the pathogenesis of follicular neoplasia are not completely known. Recent studie...

ea0037ep1002 | Thyroid (non-cancer) | ECE2015

Prevalence of thyroid dysfunction in Spain: diabetes study

Valdes Sergio , Maldonado-Araque Cristina , Tapia Maria Jose , Lago Ana , Perez-Valero Vidal , Goday Albert , Castano Luis , Delgado Edelmiro , Vendrell Joan , Rojo-Martinez Gemma , Soriguer Federico

Introduction: Thyroid dysfunction is a common health problem. Its prevalence may vary in different populations, and in Spain, it has not been sufficiently studied. The aim of this study was to evaluate the prevalence of thyroid dysfunction (clinical and subclinical) in our country.Materials and methods: The diabetes study is a national, cross-sectional, population-based survey. Target population: the entire Spanish population >18 years. Sample: >...

ea0070aep621 | Pituitary and Neuroendocrinology | ECE2020

9-CIS retinoic acid decreases pomc expression and cell viability in experimental model of ectopic cushing syndrome

Regazzo Daniela , Barbot Mattia , Ceccato Filippo , Nora Albiger , laura lizzul , Fiorella Calabrese , Federico Rea , Andrea Zuin , Boscaro Marco , Occhi Gianluca , Carla Scaroni

Ectopic Cushing syndrome (EAS) is a rare condition characterized by ACTH-dependent hypercortisolism resistant to normal physiologic suppression by glucocorticoids. EAS is due to an extra-pituitary tumor producing bioactive molecules generated by post-translational cleavage of the proopiomelanocortin gene (POMC). EAS is associated with significant morbidity and mortality and although surgical resection of the primary ACTH-producing tumor remains the mainstay of therapy, not all...

ea0070aep788 | Reproductive and Developmental Endocrinology | ECE2020

Clinical and genetic overlap between congenital hypogonadotropic hypogonadism and cornelia de lange syndrome

Xu Cheng , Messina Andrea , Acierno James , Niederlander Nicolas , Santoni Federico , Papadakis Georgios , Pignatelli Duarte , Avbelj Stefanija Magdalena , Keefe Kimberly , Balasubramanian Ravikumar , Crowley William , Pitteloud Nelly

Background: Congenital hypogonadotropic hypogonadism (CHH), a clinically and genetic heterogenous sydrome, is caused by > 40 known loci whose mutations share the ability to cause defects in the ontogeny of the GnRH neuron network leading to absent/incomplete puberty and infertility. Cornelia de Lange Syndrome (CdLS) is similarly heterogenous disorder (distinctive facies, psychomotor delay, growth retardation and upper limb malformation) caused by mutations in 7 different g...

ea0070aep889 | Thyroid | ECE2020

Iodine deficiency and mortality in spanish adults. [email protected] study

Valdes Sergio , Colomo Natalia , Maldonado-Araque Cristina , García-Fuentes Eduardo , Calle-Pascual Alfonso , Castaño Luis , Delgado Elias , Franch-Nadal Josep , Soriguer Federico , Rojo-Martinez Gemma

Objective: To study the association between the state of iodine nutrition, and the risk of total and cause mortality in a representative sample of the Spanish adult population.Design: Longitudinal observational study to estimate mortality risk according to urinary iodine (UI) concentrations using a sample of 4370 subjects >18 years representative of the Spanish adult population participating in the national study [email protected] (2008–2010). We used ...

ea0032p133 | Calcium and Vitamin D metabolism | ECE2013

Plasma lipid levels in relation to the status of vitamin D sufficiency

Gonzalez-Molero Inmaculada , Rojo Gemma , Dominguez Marta , Morcillo Sonsoles , Rubio Eleazara , Gutierrez CArolina , de Adana MArisol Ruis , Almaraz Maria Cruz , Soriguer Federico

Introduction: Several studies have investigated a possible action of vitamin D metabolites on different lipid fractions but the possible mechanism by which they could act remain unknown, with varying results in observational and intervention studies.Objective: To study the relation between vitamin D levels and lipids levels.Methods: We undertook a population-based cohort study in Spain. At baseline (1996–1998), 1226 subjects w...