Searchable abstracts of presentations at key conferences in endocrinology

ea0032p152 | Calcium and Vitamin D metabolism | ECE2013

Vitamin D deficit and metabolic syndrome

Molero Inmaculada Gonzalez , Rojo GEmma , Dominguez-Lopez Marta , Rubio Eleazara , Gutierrez Carolina , Morcillo Sonsoles , Esteva Isabel , Ruiz de Adana Marisol , Soriguer Federico

Background and aims: To assess the relationship between 25-hydroxyvitaminD levels and prevalence and incidence of metabolic syndrome.Methods: We undertook a population-based cohort study in Spain. At baseline (1996–1998), 1226 subjects were evaluated. Follow-up visits were performed in 2002–2004 and 2005–2007. At baseline and follow-up, participants underwent an interview and a standardized clinical examination with an oral glucose toleran...

ea0032p153 | Calcium and Vitamin D metabolism | ECE2013

Vitamin D deficiency predicts incidence of obesity

Gonzalez-Molero Inmaculada , Rojo Gemma , Dominguez-Lopez Marta , Rubio Eleazara , Gutierrez Carolina , Morcillo Sonsoles , lmaraz Maria Cruz , Ruiz de Adana Marisol , Esteva Isabel , Soriguer Federico

Background and aims: To assess the relationship between obesity and the incidence of hypovitaminosis D and investigate the relationship between 25-hydroxyvitamin D levels and incidence of obesity.Methods: We undertook a population-based cohort study in Spain. At baseline (1996–1998), 1226 subjects were evaluated. Follow-up visits were performed in 2002–2004 and 2005–2007. At baseline and follow-up, participants underwent an interview and a...

ea0032p514 | Endocrine tumours and neoplasia | ECE2013

Characterization and sub-cellular localization of somatostatin receptors in DU-145 and PC-3 human androgen-independent prostate cancer cells: effect of mono- and bi-specific somatostatin analogs on cell growth

Ruscica Massimiliano , Arvigo Marica , Steffani Liliana , Gatto Federico , Albertelli Manuela , Culler Michael D. , Valenti Luca , Minuto Francesco , Macchi Chiara , Ferone Diego , Magni Paolo

Somatostatin (SRIF) is an inhibitory hormone that plays a regulatory role in several cell functions including cell proliferation. SRIF acts through five specific membrane receptors (sst1-5), expressed on SRIF-target cells. SRIF and ssts may play a significant role in the progression and neuroendocrine differentiation of human prostate cancer (PCa). However, conflicting results have been reported in the literature on ssts heterogeneity and specific cell localization in PCa. Aim...

ea0032p756 | Obesity | ECE2013

Circulating endocannabinoids are differentially modulated during the oral glucose tolerance test

Fanelli Flaminia , Garelli Silvia , Mezzullo Marco , Di Dalmazi Guido , Ponti Federico , Manso Jacopo , Benetta Elisa Dalla , Bazzocchi Alberto , Vicennati Valentina , Battista Giuseppe , Pasquali Renato , Pagotto Uberto

The endocannabinoid system (ECS) is involved in the regulation of food intake and energy expenditure. Increased level of EC lipid mediators anandamide (AEA) and 2-arachydonoylglycerol (2AG) and/or a higher expression of cannabinoid receptor type 1 in central and peripheral districts are supposed to contribute to the development and maintenance of obesity and related dismetabolism. To understand the ECS response to insulin signal and to anthropometric and biochemical parameters...

ea0032p1081 | Thyroid cancer | ECE2013

A novel multi-target pyrazolopyrimidine derivative with anti-neoplastic properties, CLM29, is active against medullary thyroid cancer in vitro and in vivo

Fallahi Poupak , Ferrari Silvia Martina , Bocci Guido , La Motta Concettina , Ruffilli Ilaria , Di Domenicantonio Andrea , Corrado Alda , Mancusi Caterina , Danesi Romano , Da Settimo Federico , Miccoli Paolo , Antonelli Alessandro

Introduction: CLM29, a pyrazolo[3,4-d]pyrimidine compound, inhibits several targets (including the RET tyrosine kinase, epidermal growth factor receptor, vascular endothelial growth factor receptor and has an anti-angiogenic effect). Recently it has been shown to inhibit proliferation and migration in primary papillary dedifferentiated thyroid cancer cells. The aim of this study is to evaluate the anti-tumor activity of CLM29 in medullary thyroid cancer (MTC).<p c...

ea0032p1140 | Thyroid cancer | ECE2013

Ultrasonographic signs suggestive of malignancy in thyroid nodules

Molero Inmaculada Gonzalez , Vallejo-Mora Rosario , Dominguez-Lopez Marta , Romero Stella Gonzalez , Torres Francisca Garcia , de Adana Marisol Ruiz , Soriguer Federico

Introduction: Thyroid ultrasound is a widely used tool in monitoring thyroid nodule, allowing us to assess the size and other sonographic signs suspicious of malignancy, facilitating decisions about diagnosis and treatment.Objectives: To evaluate the presence of ultrasonographic signs suggestive of malignancy in patients with thyroid carcinoma in our hospital.Material and methods: Retrospective study of 63 patients with thyroid car...

ea0028p236 | Pituitary | SFEBES2012

Evaluation of the expression of vesicular protein (SNARE) isoforms in human pituitary adenomas

Garcia Edwin , Trivellin Giampaolo , Michael Powell , Grieve Joan , Sabin Ian , Alusi Ghassan , Louis Pobereskin , Shariati Babak , Roncaroli Federico , Mendoza Nigel , Grossman Ashley , Harper Elaine , Korbonits Marta

Background: Botulinum neurotoxin inhibits muscle function by interfering with neurotransmitter release from secretory vesicles. The mechanism underlying this effect involves cleavage of SNARE proteins which are required for vesicle docking at the plasma membrane. The ability of botulinum neurotoxin serotypes to cleave SNARE proteins and inhibit secretion is being exploited for therapeutic purposes by Syntaxin Ltd with their ‘targeted secretion inhibitor technology’ (...

ea0022p151 | Cardiovascular endocrinology and lipid metabolism | ECE2010

Is obesity a further cardiovascular risk factor in patients with erectile dysfunction?

Corona Giovanni , Monami Matteo , Boddi Valentina , Daniela Balzi , Melani Cecilia , Federico Nelli , Sforza Alessandra , Rotella Carlo , Forti Gianni , Mannucci Edoardo , Maggi Mario

Introduction: Erectile dysfunction (ED) and, in particular, arteriogenic ED have been proposed as new markers of risk for incident major adverse cardiovascular events (MACE). Reduced penile blood flow is more common in obese people than in leaner ED subjects. The aim of this study is to explore the interaction of overweight/obesity and penile blood flow in the prediction of incident MACE.Methods: This is an observational prospective cohort study evaluati...

ea0016s14.2 | Basic highlights | ECE2008

Dopamine receptor 2 activation reduces cells viability in non-functioning pituitary adenomas by inhibiting vascular endothelial growth factor secretion

Zatelli Maria Chiara , Tagliati Federico , Luchin Andrea , Ambrosio Maria Rosaria , Cimino Vincenzo , Bondanelli Marta , Scanarini Massimo , Maira Giulio , De Marinis Laura , degli Uberti Ettore

Dopamine (DA) therapy of non-functioning pituitary adenomas (NFA) can result in tumor stabilization and shrinkage. However, this effect is not always apparent and the mechanism of action is still unknown. Previous evidence showed that DA inhibits pituitary Vascular Endothelial Growth Factor expression (VEGF), that, in turn, is related to pituitary tumor growth. Our study aimed at clarifying whether VEGF secretion modulation might mediate the effects of DA agonists and chimeric...

ea0014oc3.1 | Endocrine tumors &amp; neoplasia | ECE2007

Multiple somatostatin receptor subtypes activation reduces cell viability in non-functioning pituitary adenomas by inhibiting Vascular Endothelial Growth Factor secretion

Zatelli Maria Chiara , Piccin Daniela , Tagliati Federico , Ambrosio Maria Rosaria , Bianchi Antonio , Bondanelli Marta , Schmid Herbert A , Scanarini Massimo , Marinis Laura De , Maira Giulio , Uberti Ettore C degli

Somatostatin (SRIF) analogs have been employed in medical therapy of non-functioning pituitary adenomas (NFA), with contrasting results. Previous evidence showed that SRIF can exert its antiproliferative effects by reducing Vascular Endothelial Growth Factor (VEGF) secretion and action, and that VEGF expression may be related to pituitary tumor growth. The aim of our study was to clarify the possible effects of a multireceptor SRIF ligand on VEGF secretion and cell proliferati...