Endocrine Abstracts

Background: Currently, no effective medical treatment exists for recurrent and aggressive craniopharyngiomas that are resistant to conventional therapies, including repeat surgeries and adjuvant radiotherapy (RT). Temozolomide is an alkylating chemotherapeutic agent and is used routinely in the management of high grade gliomas. The response to temozolomide is suggested to be dependent on the tumoral expression of O-6 methylguanine DNA methyltransferase (MGMT). Evidence ...

Usual metastatic localizations in MTC are liver, bone and lung. We report two cases with metastases in pancreas and breast.In a 51-year-old woman were discovered several nodules in the thyroid gland: 29×19 mm in the right lobe and 5 mm in the left. Calcitonine (CT) levels were 2300 and ECA 44 ng/ml. Fine-needle aspiration of the main nodule confirmed MTC. Total thyroidectomy and right jugulo carotidal lymph node dissection were performed in 1998 wit...

The characteristics of adrenal involvement in Multiple Endocrine Neoplasia type 1 (MEN1) have been defined from studies involving a limited number of patients. We have assessed retrospectively the prevalence, characteristics and evolution of adrenal involvement from the French group for the study of endocrine tumours (GTE) registry, involving 688 patients with MEN1. In our series, adrenal tumours identified at abdominal imaging occurred in 130 patients (18.9%). The mean age of...

Aim: To determine how serum procalcitonin (PCT) levels are affected in diabetic and diabetic nephropathic patients, it is important to determine whether PCT is indicative of an inflammation in these patients.Materials and methods: The study included 175 patients (75 diabetic nephropathy (group 1), 75 diabetic (group 2) and 25 non-diabetic nephropathy (group 3)) and 75 healthy volunteers. Serum and urine creatinine, serum high sensitive C- reactive protei...

Introduction: Diabetic foot is one of the important and destructive complications of diabetes. During the life time of a diabetic patient, the risk of developing foot ulcers is around 5–15%, and about 20–25% of the causes of hospitalization in diabetic patients are due to foot ulcers. 40–80% of foot ulcers can be infected and resulted in osteomyelitis. Hospitalization due to osteomyelitis is 12 times more in diabetic patients than in non-diabetic population....

Introduction: This study was designed to determine whether obesity causes inflammation on both conjunctival epithelium cells as well as on squamous metaplasia.Materials and methods: Around 61 volunteer participants who had no previous history of illness or drug use were involved in this study. Of them, nearly 20 were obese, and 41 were of normal weight. We measured the glucose and insulin values for all volunteers. We also measured the Body Mass Index (B...

IntroductionThere are very limited number of clinical studies and data on the effect of thyroid dysfunction in hypothyroidism on connective tissue. Tendinitis can be the first complaint in hypothyroidism and symptomatic relief can be provided with the appropriate treatment of primary thyroid deficiency. There are studies, showed softening in Achilles tendon with age, in patients with intermittent claudication, diabetes patients, and chronic kidney failur...

Introduction: During thyroidectomy, topical hemostatic agents (THA) (i.e. oxidized regenerated cellulose) are commonly used. The aims of this study are i) to evaluate the resolution duration of these materials sold under different brand names in the surgical bed. ii) to prospectively describe their ultrasonographic characteristics.Methods: A total of 67 patients who underwent thyroidectomy for various reasons and had THA used during surgery were included...

Background: Cushing’s syndrome, caused by an excess of circulating glucocorticoids, is associated with high morbidity and presents high inter-individual variability. The earlier the diagnosis, the better the treatment effectiveness and the prognosis. Hormone assays, routinely used, contribute to identify Cushing’s syndrome. However, no biomarker is currently available to directly quantify the biological action of glucocorticoids. Blood samples represent an easily obt...

Background: The growth hormone (GH)/insulin-like growth factor-1 (IGF-1) axis has effects on renal growth and electrolyte regulation. However, data on adverse renal comorbidities such as renal cysts and stones in acromegaly is scarce. The current study aimed to investigate the prevalence of radiologically detectable renal comorbidities and possible related factors in the acromegaly population.Methods: A total of 125 patients with acromegaly (46.4±11.6...