Endocrine Abstracts

Introduction: AVP secretion disturbances in pituitary lesions usuall, present as AVP deficienc, due to compression of the posterior pituitary lobe. Excessive secretion of AVP (syndrome of inappropriate antidiuresis) (SIAD) is ver, uncommon in patients with pituitary tumor. A few cases of non-functionating adenoma, prolactinoma, and even pituitary apoplex, were described to present with SIAD. Pituicytoma is a rare tumor of the neurohypophysis. The, usuall, present with visual d...

Background: Severe congenital growth hormone deficiency (cGHD) is a rare but potentially life-threatening condition. Even though random growth hormone (GH) can confirm cGHD during the first week of life, the diagnosis remains extremely challenging in the absence of reliable reference values in healthy neonates and thus of a best diagnostic cut-off.Aims: First, to provide solid reference values for GH concentrations in term newborns, by means of a non-inv...

Background: Invasive nonfunctioning (NF) pituitary neuroendocrine tumors (PitNETs) are non-resectable neoplasms associated to frequent relapse and significant comorbidities. As current treatments often fail against NF-PitNETs, identifying actionable therapeutic targets is essential. We focused on the angiopoietin-2 (Angpt2)/Tie2 axis, usually active in endothelial cells (ECs).Methods: ANGPT2 plasma levels in NF-PitNET patients and healthy controls were m...

Introduction: Obesity is a worldwide pandemic, and in men can often be associated with hypogonadotropic hypogonadism (HH), a finding consistent with a clear link between sex steroids and reproduction. In this study, we aimed to characterize the phenotypic spectrum of male obesity, focusing on the metabolic and reproductive effect of weight loss after bariatric surgery, as well as to explore the role of central inflammation.Methods: We conducted an observ...

Background: Several studies argued that the cardiovascular evaluation of patients with nonfunctioning adrenal incidentaloma is of particular importance, even if a direct association seems difficult to underline.Objective: We aimed to evaluate the possibility of stratifying cardiometabolic risk through metanephrine levels in patients with incidentally discovered nonfunctioning adrenal adenoma.Design: In this retrospective cross-sect...

Background: Only few cases of patients with adrenal disorders affected by coronavirus disease 2019 (COVID-19) have been reported so far. In this study, clinical outcome data of patients with adrenal disorders and COVID-19 infection has been collected by the ESE Rare Disease Committee and ENDO-ERN via the European Registries for Rare Endocrine Conditions (EuRRECa) project.Methods: This questionnaire included 32 questions on collecting quantitative and qua...

During the spring of 2020, a national lockdown was adopted in Italy to prevent COVID-19 pandemic spread. Restrictive measures have been associated with impaired psychological outcome in the general population. As patients with Cushing’s Syndrome (CS), including Cushing’s disease (CD), adrenal CS (ACS), and ectopic CS (ECS), are reportedly associated with a higher prevalence of anxiety, stress susceptibility, depression, and maniac episodes, during both active disease...

Background: Since the preliminary epidemiological data concerning the coronavirus disease 2019 (COVID-19) has been availabe, clear sex disparity has been evident, with males, although not more frequently affected, often experiencing worse outcomes when compared to women. The short and long term andrological effects of coronavirus disease 2019 (COVID-19) have not been clarified. The aim of the present study is to systematically review and meta-analyze all available data regardi...

Aberrant epigenetic features occurring in parathyroid tumors involve DNA methylation, histone methylation, and non-coding RNAs. RASSF1A and APC were frequently downregulated in human cancers. Here, we investigated RASSF1A and APC methylation status in a series of parathyroid tumors from Italian patients with primary hyperparathyroidism (PAds, n=80), confirming RASSF1A and APC promoter methylation as a hallmark of sporadic parathyroi...

In Wuhan China in December 2019, cases of severe atypical viral pneumonia emerged, and the World Health Organization declared COVID-19 a pandemic. In this critical context, health workers were on the front lines, directly participating in the evaluation, diagnosis, and treatment of patients with COVID-19. The objective of our work was to evaluate stress and burnout in health workers and to measure hair cortisol levels as a stress biomarker during the second wave.<p class="...