Endocrine Abstracts

Objective: Transsphenoidal surgery (TSS) presents the treatment of choice for Cushing’s disease (CD), 95% microadenomas. Remission and recurrence rates vary dependent on tumor size, extension, adenoma visibility on magnetic resonance imaging, and neurosurgical expertise. Remission rates in the postoperative vary between 55 and 85%, with a recurrence of up to 25%. The aim of this study was to describe the rate of remission and recurrence of CD in our midst after TSS, and c...

The myokine irisin is secreted after cleavage of the transmembrane protein Fibronectin type III domain-containing protein five and was shown to induce a thermogenic program in white adipose tissue. This cleavage can be induced by exercise, thus linking exercise with browning of adipose tissue. We investigated the response of Fndc5/irisin as well as its inducer Peroxisome proliferator-activated receptor gamma co-activator 1α (Ppargc1a) in mice long-term selected for high t...

Introduction: Acromegaly is an endocrinopathy that affects many different organ systems and leads to multiple comorbidities. Data on morphologic pathology of kidneys in acromegaly is scarce.Methods: We investigated 19 acromegalic patients (11 male, mean age 57.8±12.1 years) presenting in our outpatient clinic. We evaluated each patient’s kidneys by ultrasound, measuring organ dimensions and volume as well as noting any pathologic findings.<...

Introduction: Classic congenital adrenal hyperplasia due to 21-hydroxylase deficiency (21OHD CAH) is a rare genetic disorder resulting in impaired cortisol biosynthesis, increased steroid precursors, and excess androgen production. Inhibition of adrenocorticotropic hormone (ACTH) release via antagonism of the corticotropin-releasing factor-1 (CRF1) receptor could reduce adrenal androgen production, thereby reducing the amount of exogenous glucocorticoids required for androgen ...

Background: Hypertension is one of the widespread cardiovascular pathology in patients with primary hyperparathyroidism (PHPT).The renin-angiotensin-aldosterone system (RAAS) is a key system in the regulation of blood pressure and its interactions with mineral metabolism are described. Our previous study* of PHPT patients revealed a significant decrease in plasma renin activity (PRA) and serum aldosterone levels in the early postoperative period and also positive correlations ...

Background: Cushing’s disease (CD) develops as a result of ACTH-secreting pituitary adenoma. Transsphenoidal selective surgery (TSS) is the first-line therapy, and success is largely determined by the experience of the surgeon. There are several reasons for the persistence of the disease, but it is almost impossible to predict such an outcome in advance, which leads to multiple interventions and has a pronounced effect on the quality of life of patients.<p class="abs...

Background: To characterize the diagnostic performance of 18-Fluoroethylcholine-PET-CT (FCH-PET-CT) to localize parathyroid adenomas (PA) in primary hyperparathyroidism (pHPT) when ultrasound (US) and MIBI-Scan (MibiS) fail to localize – intraoperative correlation and one-year follow up.Method: Beginning in 07/2017 18-FCH-PET was employed in patients with proven pHPT in whom US and MS delivered either incongruent or negative findings. All patients ...

Background: GH resistance or primary IGF1 deficiency (PIGFD) presents with growth failure, low serum IGF1 and normal/elevated serum GH. PIGFD comprises a spectrum of phenotypic and biochemical abnormalities for which genetic GH–IGF1 axis defects may be causative.Objective: Genotyping of PIGFD patients referred for sequencing of candidate genes.Methods: From 2008 to 2013, 62 patients (42 males and 20 females), median age 6.9 ye...

Background: Recent reports suggest that female sex could be an indicator of better response to liraglutide in patients included in clinical trials.Aim: To compare efficacy of liraglutide in women and men with type 2 diabetes mellitus (T2DM), in real clinical practice.Patients and methods: Our study included 116 patients with T2DM and obesity (BMI >30) attending outpatient clinic, which initiated with liraglutide (0.6 mg/daily f...

Background: It is well established that subclinical hypothyroidism (SCH) is associated with mild ventricular dysfunction and early cardiovascular disease (CVD), but it is unknown if there is an underlying defect in cardiac bio-energetic function.Objective: To quantify the cardiac phosphocreatine/ATP (PCr/ATP) ratio in SCH, compare with healthy controls (HC) and to measure the effect of 6 months of thyroxine treatment.Method: Cardia...