Endocrine Abstracts

Cushing’s syndrome caused by ectopic ACTH secretion (EAS) constitutes ~10% of Cushing’s syndrome (CS).The aim of this study was to present experience of our Clinic with EAS.).Patients: Twelve patients, aged 14–70 years: four females and eight males.Outcomes and measurements: Clinical features, medical examination, morning electrolytes, glucose level, serum cortisol, ACTH levels, midnight plasma...

Background and aims: Obesity is linked to a low-grade and chronic systemic inflammation that improves after a significant weight loss. In the same way, depressive disorder has been suggested to be associated with systemic inflammation up regulation. We aimed to explore whether, after a significant weight loss, the presence of depressive symptoms was associated with differences in terms of inflammatory markers and quality of life compared with individuals without significant de...

Introduction: Mechanism of pathogenesis of pituitary adenomas is still unknown. Gene expression differences in pituitary cells of different origin are not extensively described. Identification of genes specific for pituitary adenomas should enable better understanding of differences in their response to therapy, especially to radiotherapy.Aim: The aim of our study was to evaluate the correlation of coexpression of distinct pituitary adenoma genes based o...

Background: Graves’ disease (GD) is a complex disease in which genetic predisposition is modified by environmental factors. The pathogenesis of GD and Graves’ orbitopathy (GO) might have a different genetic background – in some patients GO is observed before or late after diagnosis of GD hyperthyroidism. The aim of the study was to assess genetic predisposition to GD and GO in young patients (age of diagnosis ≤30 years of age), in which the time of environ...

Introduction: Acromegaly is a rare diseaseresulting most commonly from pituitary adenoma. A chronic increase of growth hormone (GH) and insulin-like factor 1 (IGF-1) leads to many systemic complications including osteoporosis and fractures. Radiofrequency echographic multi-spectrometry (REMS) is a new non-ionizing technique to diagnose osteoporosis.Purpose: The objective of the study was to evaluate bone mineral density (BMD) by REMS in patient...

Introduction: Combined pituitary hormone deficiency (CPHD) due to PROP1 mutation is a rare cause of childhood-onset pituitary disfunction. Treatment with growth hormone is crucial for the proper development during childhood and adolescence, and to maintain adequate metabolic processes in the adulthood. There are other factors influencing patients metabolism e.g. steroid and estradiol/testosterone treatment.Aim: To assess metabolic status of patients with...

Introduction: The aim of this study was to assess the efficacy of peptide receptor radionuclide therapy (PRRT) with the use of 90Y-DOTATATE and the survival rate of patients with disseminated or non-operable neuroendocrine tumors (NETs).Methods: In the time period from June 2006 to October 2012, 70 patients were treated with PRRT in our department. The 90Y-DOTATATE therapeutic activity was calculated per total body surface area up t...

Introduction: Information regarding eating disorders (ED) in postsurgical outcomes after bariatric surgery (BS) is scarce.Objectives: To analyze the effect of BS on ED and to investigate if ED influence clinical, biochemical or psychological outcomes.Methods: Sixty patients (78.3%♀, age 46.35±9.89, months since BS 46.28±28.1) who underwent BS, with a minimum follow up of 12 months, were evaluated cross-sectionally. ...

The incidence of gastric neuroendocrine tumors (GNT) is increasing, what can be explained by the increased detection caused by the common use of the endoscopy and the pervasive use of acid suppressive therapy leading to enterochromatofine like cells proliferation. There are numerous new diagnostic/therapeutic GNT methods in use like: EUS, SRS, somatostatin therapy and 90Y/177Lu-DOTA-TATE radiotherapy.Materials and methods: In 1998–2008 37 patients w...

Refractory or severe hypercalcemia is important clinical problem as it can lead to serious complications such as arrhythmias, acute or chronic pancreatitis, gastric ulcer, water and electrolyte balance disturbances, osteoporosis, psychoses and even to hypercalcemic crisis. Most often it is diagnosed in parathyroid cancer (PC). It is also observed in benign primary hyperparathyroidism (HPTH) in case of difficulties with adenoma’s localization. Routinely treatment includes ...