Endocrine Abstracts

Introduction: We have previously reported on the considerable variability in ACTH-secreting pituitary adenomas in terms of responses to major modulators in vitro (Pecori Giraldi et al J. Neuroendocrinol. 2011). Further studies revealed also differences in gene expression profiles in specimens analyzed by microarray analysis. Aim of this study is to correlate transcriptome expression pattern in archival human ACTH-secreting adenomas with clinical features of patients p...

Introduction: The possible change in the pattern of hormonal secretion by pituitary tumours is a very intriguing issue indeed, notably in the case of corticotroph-cell adenomas.Methods/design: We retrospectively reviewed the records of 1259 consecutive endoscopic endonasal surgical procedures for pituitary adenomas from 1998 to 2013. Of these, 132 were ACTH-secreting adenomas associated with Cushing’s disease (CD) and 44 were silent corticotroph-cel...

Steroid profiling by liquid chromatography–tandem mass spectrometry (LC–MS/MS) offers an accurate and simultaneous detection of a panel of steroids with several advantages over traditional assays. However, only a few studies have investigated the steroid profiling in sporadic adrenocortical adenomas. Our aim was therefore to investigate steroid secretion by LC–MS/MS in patients with non-secreting adrenocortical adenomas (NSA) and subclinical hypercortisolism (SH...

Introduction: Pasireotide is the first pituitary-directed drug approved for Cushing’s disease (CD). We report our 10-years experience with pasireotide in CD reviewing and analysing data about all the patients treated with pasireotide at our referral centre both in randomised trials and in clinical practice.Patients and methods: Twenty active CD patients were treated. Fourteen patients were treated with pasireotide in randomised trials and six patien...

Hyperandrogenic disorders cause psychological implication in young girls, limiting the quality of life. Salivary cortisol (SalF) testing was proved to be useful in the evaluations of acute stress responses. Aim of this study was to investigate SalF responses to a stressor event in late adolescent females. We selected 165 drug-free females aged 16–19 years from a cross-sectional epidemiological study. Saliva was collected in the morning before and after a stressor event co...

Introduction: Hyponatremia is the most frequent electrolyte disorder in hospitalised patients. Our aim was to determine the incidence, mean hospital stay, readmission rate and mortality rate among patients with acute heart failure (HF) and hyponatremia.Methods: Retrospective analysis of data collected from the minimum data set (MDS) of Spanish National health System during 2005–2012 from discharged patients of Internal Medicine with HF and hyponatre...

Reduced health-related quality of life (HRQoL) and impairment in neurocognitive functions are a possible complaint in patients with pituitary adenoma. Psychiatric comorbidities in Cushing’s disease are well known. However recent studies showed HRQoL reduction and psychiatric symptoms in patients with pituitary disease with or without hormonal excess. Aim of this study is to analyse HRQoL, psychiatric symptoms and neurocognitive functions in patients with pituitary adenoma...

Introduction: The prevalence of hyperthyroidism in patients admitted in Internal Medicine at Spanish hospitals is 0.8%. Proper diagnosis and management of HTD in these patients is still a challenge and therefore, the analyses of the factors involved in the prognosis and survival is of interest.Methods: Data from the minimum-data-set (MDS) of Spanish National health System were collected during 2005–2012 from discharged patients of Internal Medicine ...

Introduction: The association between vitamin D (25(OH)D) levels and metabolic parameters is not confirmed in some population studies. 25(OH)D concentration in blood is influenced by seasons and this covariate may explain some discordant results. The first aim of our study was to evaluate the prevalence of 25(OH)D deficiency in a population of obesity children (2–18 years) living in the North of Italy (latitude, 45°27′n) with respect to the season. The...

Introduction: New onset diabetes after transplantation (NODAT) is a recognized metabolic complication of kidney transplantation: its rates at 12 months after transplantation is between 20 and 50% for kidney recipients and it is associated with increased risks of graft rejection, infection, cardiovascular disease and death. Transplant-specific risk factors for NODAT,such as corticosteroids and calcineurin inhibitors, play a dominant role in its pathogenesis. Furthermore polymor...