Endocrine Abstracts

A 53 year old man, without any previous medical history, presented acutely to the Accident and Emergency Department with a 5 day history of vomiting and abdominal pain on a background of weight loss, fatigue, polyuria and polydipsia for 4 weeks. On examination he was obviously tanned and thin. He was clinically dehydrated and had palpable hepatomegaly. Immediate biochemical testing revealed hyperglycaemia with a venous blood glucose of 20.7 mmol/l, a metabolic acidosis with a ...

Background: The global uptake of bariatric surgery in men, despite high prevalence of morbid obesity and associated co-morbidities, is significantly lower compared to women. It is unclear if this is due to a perception of poorer outcomes in men. AimsTo compare weight loss and metabolic outcomes in men versus women after bariatric surgery.Design and methods: We performed a retrospective, observational cohort analysis of 80 men matched to 80 women for base...

Whilst bariatric surgery is the most effective therapy for idiopathic morbid obesity in adults, little is known about its effectiveness in patients with monogenic obesity syndromes. We report 5-year outcome of gastric bypass surgery in a young man with severe super-obesity associated with melanocortin four receptor (MC4R) mutation.A 22-year-old male with a weight of 221.6 kg and BMI 76.7 kg/m2 was referred to our centre for bariatric surgery. ...

Background: Thyroid function within the normal range has been shown to influence body weight in a population. Even slightly elevated serum TSH levels are associated with an increase in the occurrence of obesity. It is unclear whether significant weight loss has the reverse effect on thyroid function, and studies to date have yielded inconsistent results.Aims: Our aim was to describe changes in TSH and fT4 in relation to durable and significant...

Introduction: The 2015 American Thyroid Association (ATA) guidelines on the management of thyroid nodules and cancer recommend specific size cut-offs for fine needle aspiration (FNA) cytology. We assessed the correlation between sonographic and cytological stratification as per the guidelines, with emphasis on the size cut-offs.Methods: In a ‘real world’ prospective study, we sonographically stratified 562 thyroid nodules prior to performing ul...

Background: Bardet-Biedl syndrome (BBS) is a rare genetic condition characterised by ciliary protein dysfunction leading to multi-organ damage. Patients with BBS can suffer from hyperphagia and severe obesity from childhood and associated weight-related comorbid diseases such as type 2 diabetes and hypertension. However, the optimal weight management strategy and response to weight loss pharmacotherapy is unknown. Case presentation: We present a case of ...

Introduction: It is currently unclear how hyperthyroidism and its treatment impact on the weight trajectory of an individual. Anticipated weight gain with the treatment of hyperthyroidism is one of the main concerns of patients.Methods: We prospectively examined the BMI changes that occurred with hyperthyroidism and its therapy and sought risk factors for treatment-related weight gain. An established institutional protocol for the management of hyperthyr...

Introduction: The prevalence of clinical obesity in women with polycystic ovarian syndrome (PCOS) is 50%. Weight loss is effective at enhancing insulin sensitivity, reducing hyperandrogenaemia, improving hirsutism and restoring menstrual regularity and fertility in PCOS. However, women with PCOS appear to be less responsive to weight loss interventions including some bariatric surgical procedures. The aim of this study was to compare weight loss outcomes of gastric bypass surg...

Obesity increases the risk of pregnancy-related complications such as miscarriage, foetal abnormalities, hypertension, diabetes, thrombosis, caesarean section and infection. Although bariatric surgery addresses some of these risks, women should defer pregnancy for 12-24 months postoperatively until weight loss has plateaued due to concerns regarding limited maternal weight loss and foetal nutritional deficiency. The aim of this study was to evaluate the impact of pregnancy on ...

Background: Hyperadrogenemia is one of the most commonly encountered endocrine disorders in reproductive-aged women. By far the most common causes of androgen excess are functional which account for more than 90% of cases. Androgen and ovarian tumours producing excess androgen are however very rare and only account for about 0.2% of cases.Case history: A 62-year-old lady admitted to hospital with pneumonia was found to have an ill defined, firm, non-tend...