Searchable abstracts of presentations at key conferences in endocrinology

ea0031p22 | Bone | SFEBES2013

Renal replacement therapy to treat severe hypercalcaemic crisis: case series

Prague Julia , Mustafa Omar , Whitelaw Ben , Jenkins Rebeka , Crown Anna , Vaughan Nick , Schulte Klaus-Martin , Diaz-Cano Salvador , McGregor Alan

Background: The initial management of hypercalcaemia is well described: aggressive intravenous rehydration and subsequent intravenous bisphosphonates if required. Isolated case reports document the use of haemo/peritoneal dialysis and haemofiltration in the management of severe hypercalcaemia. We report three cases that required renal replacement therapy to treat severe hypercalcaemia.Case series: A 21-year-old male presented with abdominal pain and vomi...

ea0027oc1.6 | Oral Communications 1 | BSPED2011

Twenty novel mutations in nicotinamide nucleotide transhydrogenase (NNT) causing FGD

Metherell Lou , Meimaridou Eirini , Kowalczyk Julia , Guasti Leo , Hughes Claire , Mann Nicholas , Banerjee Ritwik , King Peter , Clark Adrian

Familial glucocorticoid deficiency (FGD;OMIM 202200) results from the inability of the adrenal cortex to produce cortisol in response to ACTH stimulation. Half of all cases are caused by mutations in MC2R, MRAP or STAR. SNP array genotyping of FGD patients of unknown aetiology mapped a disease locus to chromosome 5p13-q12. Targeted exome sequencing of 5p13-q12 in one patient identified a homozygous mutation, p.Ala533Val, in nicotinamide nucleotide transhyd...

ea0022p344 | Diabetes | ECE2010

Systemic effect of insulin on local cytokine concentrations in adipose tissue and muscle in healthy humans

Mader Julia K , Ikeoka Dimas , Weinhandl Heinz , Pachler Christoph , Bock Gerlies , Plank Johannes , Ellmerer Martin , Pieber Thomas R

Introduction: Cytokines are produced in different tissues under physiological and pathophysiological conditions. The present study was performed to compare local concentrations of cytokines in subcutaneous adipose tissue and muscle using the open flow microperfusion (OFM) technique, as well as to investigate systemic effects of insulin on interstitial concentrations of these mediators.Methods: Ten healthy volunteers (age: 27±4 years, BMI: 22.6±...

ea0022p834 | Thyroid | ECE2010

The accuracy of fine needle aspiration cytology in the tryroid nodule study, in a tertiary hospital

Torres Beatriz Torres , Castro Gonzalo Maldonado , Cucalon Luis Irigoyen , Santaren Blanca Caton , De Diego Julia , Larreina Rafael Ezquerra

Background: Fine Needle Aspiration (FNA) is currently the primary diagnostic procedure in diagnosing thyroid malignancy. The aim of this study was to report our experience with FNA, and its accuracy.Materials and methods: Retrospective analysis of 166 patients who were operated of thyroid nodule in our hospital from 2003 to 2008, all of them had a previous FNA cytology results. There were evaluated some clinical variables and the correlation with final h...

ea0016p781 | Thyroid | ECE2008

Iodine status in pregnant women: do they have sufficient information about the importance of iodine nutrition during the pregnancy?

Marco Amparo , Vicente Almudena , Castro Enrique , Canovas Barbara , Sastre Julia , Cruces Eva , Maqueda Esther , Iglesias Maria Lopez , Lopez Jose Lopez

The recommended nutrient intake (RNI) for iodine during pregnancy has been re-evaluated in 2005 by an international expert committee under the auspices of the World Health Organization (WHO). The consensus reached was that the RNI for iodine during pregnancy should range between 200 and 300 μ/d with an average of 250 μ/d.To asses the adequacy of the iodine intake during pregnancy in a population, urinary iodine concentration (UIC) should be mea...

ea0016p818 | Thyroid | ECE2008

Clinical evaluation of 3rd generation assay for thyrotropin receptor autoantibodies in autoimmune thyroid diseases

Schott Matthias , Graeber Claudia , Domberg Julia , Charko Roswitha , Hermsen Derik , Schinner Sven , Scherbaum Werner A , Willenberg Holger S

Recently a new procedure for measuring serum TSH receptor (TSHR) autoantibody (TRAb) was reported in which the autoantibodies inhibit binding of a human monoclonal thyroid stimulating antibody M22 (labeled with biotin) to TSHR-coated ELISA plate wells. This assay was termed 3rd generation TRAb assay. The aim of the present study was to clinically evaluate the TRAb 3rd generation assay in comparison with the 2nd generation TRAb assay (TRAb-2nd) based on the recombinant human TS...

ea0015p373 | Thyroid | SFEBES2008

An unusual cause of a thyroid mass

Thomas Julia , Norton Andrew , Calaminici Maria , Plowman P Nicholas , Richards Polly , Alusi Ghassan , Montoto Silvia , Akker Scott

A 24-year-old woman presented with stridor resulting from a large, firm, anterior neck mass. At age six she had been treated for acute lymphoblastic leukaemia (ALL) with vincristine, prednisolone, daunorubicin, asparaginase, prophylactic cranial radiotherapy and intrathecal methotrexate. She also had primary hypothyroidism with strongly positive thyroid peroxidase antibodies.The mass had been gradually enlarging for 6 months, causing exertional breathles...

ea0056gp70 | Cardiovascular | ECE2018

Changes in lipid profile 5 years after bariatric surgery: laparoscopic Roux-en-Y gastric bypass versus laparoscopic sleeve gastrectomy

Climent Elisenda , Benaiges David , Flores-Le Roux Juana A , Ramon Jose M , Julia Helena , Pedro-Botet Juan , Goday Albert

Importance: Few studies have compared mid-term results of laparoscopic Roux-en-Y gastric bypass versus laparoscopic sleeve gastrectomy and none have focussed on lipid profile.Objectives: The main objective of this study was to compare laparoscopic Roux-en-Y gastric bypass versus laparoscopic sleeve gastrectomy with respect to 5-year remission rate of the different lipid disturbances. Secondary outcomes included relapse, late remission and incidence rates...

ea0056p1144 | Thyroid cancer | ECE2018

Changing treatment trends with radioiodine in thyroid carcinoma at the beginning of 21st century in Castilla-La Mancha (Spain)

Delgado Manuel , Sastre Julia , Quiroga Ivan , Gonzalez Javier , Torres Belvis , Aznar Silvia , Alvarez Visitacion , Herranz Sandra , Moreno Jesus , Gomez Paz

Background and objective: The incidence of differentiated thyroid carcinoma (DTC) is increasing worldwide. Radioiodine (RAI) ablation is one of the main elements in the therapy of DTC after surgical removal of the gland. This study aims to compare the use of I131 in a Spanish Cohort of DTC before and after the American Thyroid Association (ATA) 2009 guidelines.Patients and methods: The Cadit-CAM study was designed to evaluate retrospectively characterist...

ea0073aep110 | Calcium and Bone | ECE2021

Is necessary long-term follow-up of all patients with primary sporadic hyperparathyroidism undergoing parathyroidectomy?

Castro Ana , Cruz Andrea , Rocío Revuelta , Vicente Almudena , Sastre Julia , Castro Enrique , Mollejo Manuela , Carrasco Miguel

IntroductionPost parathyroidectomy cure in primary hyperparathyroidism (PHPT) is defined as normocalcemia six months after surgery. The frequency of persistent or recurrent post-surgical disease according to lengthy follow-up studies varies between 1% and 14%.ObjectiveTo determine if there is a subset of patients with cure criteria 6–12 months after parathyroidectomy that would not require long-term foll...