Searchable abstracts of presentations at key conferences in endocrinology

ea0035oc6.4 | Bone, calcium & vitamin D | ECE2014

The REPEAT Study: An open-label clinical trial evaluating the safety and efficacy of recombinant human parathyroid hormone, rhPTH(1–84), for the treatment of hypoparathyroidism in hungary

Lakatos Peter , Bajnok Laszlo , Lagast Hjalmar , Valkusz Zsuzsanna

In hypoparathyroidism, inadequate levels of parathyroid hormone (PTH) result in hypocalcemia and often hyperphosphatemia. Large doses of calcium (Ca) and active vitamin D are typically used to manage symptoms, although these are often associated with complications and do not address the underlying PTH deficiency. In the phase III REPLACE trial, 24 weeks of treatment with rhPTH(1–84) was associated with maintained serum Ca without urine Ca excretion increases despite clini...

ea0032p320 | Clinical case reports - Thyroid / Others | ECE2013

Torsade de pointes caused by gluten sensitive enteropathy leading to multiplex endocrine failure: case report

Csajbok Eva , Orosz Andrea , Hankovszky Peter , Rudas Laszlo , Lengyel Csaba

A 55 year-old man was brought to the emergency room because of hypotension, fatigue, fever and pain in the left shoulder. The blood glucose, sodium, potassium levels were normal. ECG showed 65/min sinus rhythm with negative T waves in the precordial leads. Blood pressure was 70/50 mmHg. Suddenly torsade des pointes occurred, which was converted to sinus rhythm with 300 mg amiodarone. Coronarography showed no significant stenosis on epicardial coronaries. During the interventio...

ea0022p216 | Clinical case reports and clinical practice | ECE2010

10 years experience with somatostatin analogue (SSA) treatment in multiple endocrin neoplasia type 1 (a case report)

Krisztian Sepp , Zsuzsanna Valkusz , Ildiko Kiss , Laszlo Pavics , Janos Julesz

Multiple endocrine neoplasia (MEN-1) is a rare congenital disease with genetic background. The MEN-1 gene encodes the menin protein, which acts as a tumour suppressor. Mutation of one allele and the inactivation of the other allele of this gene lead to clonal proliferation and to the development of tumours. The clinical manifestation of MEN-1 is a combination of endocrine (most commonly parathyreoid adenomas, entero-pancreatic endocrine tumours, pituitary tumours) and non-endo...

ea0022p780 | Thyroid | ECE2010

The serum C-reactive proteine in dysthyreosis

Laszlo Annamaria , Pascanu Ionela , Kolcsar Melinda , Gliga Camelia , Schiopu Alexandru

Introduction: The thyroid is a multifaced endocrine gland. By its hormones it has an effect on almost all organs of the body, metabolism and defence system too. The relationship between the thyroid hormones and the nonspecific defence system has been less studied.Aim: To study and prove whether the endogenous thyroxin (FT4) is involved in the nonspecific defence system of the organism. We followed the correlation between the FT4 and...

ea0026p171 | Neuroendocrinology | ECE2011

Effects of orexin–monoaminergic interactions on vasopressin secretion in rat neurohypophyseal cell cultures

Kis G K , Galfi M , Radacs M , Kadar K , Molnar Z , Molnar A H , Laszlo F , Varga C , Laszlo F A

Introduction: The effects of dopamine (DA), serotonin (5-HT), histamine (HA) adrenaline (ADR), noradrenaline (NADR) and K+ administration on vasopressin (VP) secretion were studied in 13–14 days cultures of rat neurohypophyseal (NH) cells, and it was examined whether orexin (ORX) can modify the VP release enhancement induced by these monoaminergic compounds.Methods: An enzymatic dissociation technique was used to prepare the rat NH cell c...

ea0026p341 | Obesity | ECE2011

Effects of Orexin-A on AMPK activity

Molnar A H , Kis G K , Varga C , Rakosi K , Scerif M , Laszlo F A , Laszlo F , Korbonits M

Introduction: The hypothalamic hormone orexin-A (OXA) increases food and water intake, regulates the sleep-wake cycle, muscle tone and energy balance. AMP-activated protein kinase (AMPK) is an important metabolic regulator with direct hypothalamic orexigenic and diverse peripheral effects including fat tissue and muscle.Aims: We aimed to study the influence of OXA on the activity of AMPK in the hypothalamus, subcutaneous and visceral adipose tissues, and...

ea0101ps1-01-01 | Autoimmunity | ETA2024

Modelling of mechanical stimuli through piezo1 receptor activation and its effect on adipogenic differentiation of orbital fibroblasts

Galgoczi Erika , Orsos Istvan , Molnar Zsanett , Ujhelyi Bernadett , Steiber Zita , Szabo Laszlo , Dienes Beatrix , Csernoch Laszlo , Nagy Endre V. , Katko Monika

Introduction: In the pathogenesis of thyroid eye disease (TED) activated fibroblasts in the orbital connective tissue show increased proliferation, hyaluronan (HA) production, and adipogenic differentiation potential. As a result of these, the orbital tissue volume expands and the intraorbital pressure increases. Mechanical stimuli, including high intraorbital pressure, may lead to the activation of mechanosensitive receptors, such as Piezo1, whose presence in orbital fibrobla...

ea0084op-02-07 | Oral Session 2: Pregnancy | ETA2022

Use of levothyroxine for euthyroid women with positive thyroid antibodies and infertility: Results of thesis (treatment of hypothyroidism in europe by specialists: an international survey)

Negro Roberto , Hegedus Laszlo , Attanasio Roberto , Nagy Endre V. , Papini Enrico , Zarkovic Milos , Perros Petros

Objectives: The use of levothyroxine (LT4) treatment aiming to improve fertility in euthyroid women with positive thyroid peroxidase antibodies (TPOAb), is not supported by the available evidence, however the extent to which this is applied in clinical practice is unknown. The aim of the study was to document the demographic, work-related characteristics, and therapeutic choices of European physicians in the case of euthyroid infertile women positive for TPOAb.<p class="ab...

ea0084ps1-02-12 | Hypothyroidism | ETA2022

Characteristics of specialists delivering clinical care for hypothyroidism in eupope: the “THESIS” study (treatment of hypothyroidism in europe by specialists: an international survey)

Zarkovic Milos , Attanasio Roberto , Hegedus Laszlo , V. Nagy Endre , Negro Roberto , Papini Enrico , Perros Petros

Objectives: Some hypothyroid patients are critical of their care, although this appears to vary between countries. The quality of thyroid care delivered, and the perceived patient experience may be influenced by characteristics of specialists such as age, sex, experience, and workplace setting. Here, we aimed to explore geographical differences in thyroid specialist characteristics.Methods: THESIS is a large European questionnaire survey of thyroid speci...

ea0063p1014 | Interdisciplinary Endocrinology 2 | ECE2019

Characterization of type 1 angiotensin II receptor activation induced gene expression changes in rat vascular smooth muscle cells

Szalai Laura , Porkolab Edit , Szakadati Gyongyi , Gem Janka , Kovacs Kinga , Balla Andras , Hunyady Laszlo

Angiotensin II (AngII) mainly acts through type 1 angiotensin II receptor (AT1R) to promote a broad variety of biological effects. The vascular smooth muscle cells are one of the main target of AngII and its stimulation activates numerous signaling pathways which could result in gene expression changes in these cells. We carried out Affymetrix GeneChip experiments to analyze the effects of AngII stimulation on gene expression. More than 200 genes were upregulated in response t...