Endocrine Abstracts

Background: Patients with adrenal incidentalomas and possible autonomous cortisol secretion (pACS) suffer from a high rate of cardiovascular events and mortality. We have previously showed that left ventricular mass index (LVMi) is higher in patients with pACS, compared with patients with non-functioning adenomas (NFA). To date, the management of pACS is still controversial, with a lack of consensus regarding the benefits of surgery.Objectives: This pros...

Background: The increase use of abdominal imaging have given rise in incidental discovery of adrenal masses. We report a case of a localized Castleman’s Disease(CD), mimicking an adrenal mass.Case report: A 29-year-old woman was found to have a 6 cm, well-circumscribed and hypoechoic, right adrenal incidentaloma during an abdominopelvic ultrasonography. The CT scan confirmed a suprarenal mass with heterogenous contrast enhancement. Adrenal gland cou...

Background: Type 2 diabetes mellitus (T2DM) significantly impacts Health-Related Quality of Life (HRQoL) and sexual function. The aim of this study was to evaluate sex differences in HRQoL and sexual function in patients with T2DM.Methods: We performed an ancillary study of RECOGITO trial (REmodelling in Diabetic CardiOmyopathy: Gender Response to PDE5i InhibiTOrs - NCT01803828). All patients completed the 36-item-Short-Form Health Survey (SF-36), assess...

Background: Patients with adrenal insufficiency (AI) require long-term glucocorticoid (GC) replacement therapy and generally show an increased prevalence of bone metabolism alterations. Only few data are available on bone safety of dual-release Hydrocortisone (DR-HC) therapy.Objective: To evaluate bone metabolism in both primary AI (PAI) and secondary AI (SAI) during long-term therapy with DR-HC.Methods: We studied patients with AI...

Background: Patients with Cushing’s syndrome (CS) typically show an alteration in the intrinsic coagulation pathway, leading to an increased risk of venous thromboembolism. Cortisol autonomy has been variably associated with higher risk of cardiovascular events and mortality compared to patients with non-functioning adrenal adenomas (NFA), particularly in women younger than 65 years. However, dedicated studies describing coagulation status in patients with adrenal inciden...

Background: In patients with Bardet-Biedl syndrome (BBS), signaling impairments in the melanocortin-4 receptor (MC4R) pathway lead to hyperphagia and severe obesity, which negatively impact quality of life (QOL). We evaluated the impact of setmelanotide, an MC4R agonist, on age-appropriate weight-related parameters, hunger, and QOL in a Phase 3 trial of patients with BBS to further characterize clinical benefit in this patient population.Methods: Patient...

Background: Bilateral testicular germ cell tumors (B-TCGT) are reported as rare findings (incidence 1-8%) and can be distinguish in synchronous (sB-TCGT) (recurrence within 3 months) and metachronous (mB-TCGT) (recurrence after 3 months). Risk factors of relapse are still underexplored. The aim of our study was to identify clinical, biochemical and radiological risk factors for the onset of a second tumor in a wide cohort of TGCT patients. Materials and ...

Background & Aim: Pancreatic neuroendocrine tumors (pNETs) are detected in >80% of MEN1 patients. MEN1 pNETs are well differentiated G1-G2 NETs. They are usually not surged unless a size >1–2 cm or a growth rate >0.5 cm per year. Somatostatin analogues represent one of the main therapeutic option in patients affected with G1-G2 NETs. However, neither somatostatin analogues nor other therapies have been prospectively evaluated in clinical trials specificall...

Introduction: Immune-Checkpoint Inhibitors (ICI) are frequently associated with thyroid-related adverse events (AE). Several studies analyzed thyroid disfunctions during ICI therapy, but many aspects remain to be characterized, especially for the most recent anti-PD-1 drugs. The aim of this study is to determine incidence and characteristics of PD-1 inhibitors associated thyroid dysfunction.Methods: We retrospectively analyzed data of patients with advan...

Introduction: The new Italian cytological classification of thyroid nodules published in 2014 has replaced the TIR3 ‘indeterminate’ category into two subcategory with different risk of thyroid cancer (TC): TIR3A, low-risk indeterminate lesion and TIR3B, high-risk indeterminate lesion. The aim of our study was to describe the incidence of TIR3B in a large prospective cohort of patients, the risk of TC, and its correlation with anamnestic, ultrasonographic (US) and cyt...