Searchable abstracts of presentations at key conferences in endocrinology

ea0037ep264 | Calcium and Vitamin D metabolism | ECE2015

Measuring BMD at forearm aids in diagnosing osteoporosis and identifies more patients for surgery in asymptomatic primary hyperparathyroidism

Gianotti Laura , Castellano Elena , Tassone Francesco , Pellegrino Micaela , Ghio Michela , Racca Anna , Borretta Giorgio

Introduction: Reduction in bone mineral density (BMD) is a common feature in primary hyperparathyroidism (PHPT), involving mostly cortical site. In the management of asymptomatic PHPT (aPHPT), guidelines indicate measuring BMD at lumbar spine, hip and forearm and surgery is recommended for patients with a T-score of −2.5 or less at one of these sites. However, BMD at forearm is not always performed.Aim: Our aim was to evaluate the impact o...

ea0035p19 | Adrenal cortex | ECE2014

Acute pasireotide suppression test in patients with Cushing's disease: a role in predicting long-term efficacy?

Trementino Laura , Marcelli Giorgia , Michetti Grazia , Concettoni Carolina , Boscaro Marco , Arnaldi Giorgio

Introduction: Pasireotide is a multireceptor-targeted somatostatin analogue effective in the treatment of patients with Cushing’s disease (CD) but associated with an increased risk of hyperglycaemia. We prospectively investigate the role of an acute pasireotide suppression test (PST) in predicting long-term response in CD.Methods: Eleven patients with CD (seven females, four males; mean age 45±17.3 years) received at 0900 h a single s.c. inject...

ea0035p46 | Adrenal cortex | ECE2014

Diagnostic performance of late-night salivary cortisol measured by automated chemiluminescenze immunoassay

Marcelli Giorgia , Brugia Marina , Concettoni Carolina , Trementino Laura , Michetti Grazia , Boscaro Marco , Arnaldi Giorgio

Context: Late-night salivary cortisol (LNSC) measurement has been promoted as an ideal screening test for the diagnosis of Cushing’s syndrome (CS). However, its performance using commercially available assays has not been widely evaluated and limited data are available on its use in population with chronic medical conditions.Aim: To compare the diagnostic performance of LNSC (routine use) in patients with CS and in a patients’s group with diffe...

ea0070aep1004 | Hot topics (including COVID-19) | ECE2020

Impact of covid-19 pandemic on psychophysical stress in patients with adrenal insufficiency: The corti-covid study

Martino Marianna , Aboud Nairus , Fabio Cola Marco , Giancola Giulia , Ciarloni Alessandro , Salvio Gianmaria , Arnaldi Giorgio

Background: COVID-19 pandemic is a novel, potentially adverse condition for patients with adrenal insufficiency (AI), whose life expectancy and quality of life (QoL) are impaired due to their risk of infections and stress-triggered acute events. Therapeutic usefulness of glucocorticoids in COVID-19 is debated, but infected AI patients require prompt replacement tailoring.Objectives: In a cohort of AI patients, to assess:– the...

ea0070aep1062 | Hot topics (including COVID-19) | ECE2020

The emotional outbreak of (endocrine) cancer patients during COVID-19 pandemic

Falcone Rosa , Grani Giorgio , Ramundo Valeria , Melcarne Rossella , Giacomelli Laura , Filetti Sebastiano , Durante Cosimo

Background: The 2019 coronavirus disease (COVID-19) pandemic is a public health emergency and raises the issue of psychological and physical resilience in more vulnerable patients. We investigated the emotional impact of the SARS-CoV-2 spread among cancer patients, followed at our Institution in Italy, after the restrictive measures imposed by the government and the disruption of planned clinical activities.Methods: From March 18th to April 1st, 2020, we...

ea0032p33 | Adrenal cortex | ECE2013

Salivary cortisol is a useful tool to assess the immediate response to pasireotide in patients with Cushing’s disease

Cardinaletti Marina , Trementino Laura , Concettoni Carolina , Marcelli Giorgia , Polenta Barbara , Spinello Maurizio , Boscaro Marco , Arnaldi Giorgio

Introduction: Pasireotide is a promising treatment option for patients with Cushing’s disease (CD). The measurement of salivary cortisol is useful for diagnosing hypercortisolism and monitoring patients with CD following pituitary surgery. It may also be a better index of cortisol secretion than serum cortisol or urinary free cortisol (UFC). We investigated the value of salivary cortisol in monitoring short-term efficacy of pasireotide in patients with CD.<p class="ab...

ea0032p45 | Adrenal cortex | ECE2013

Long-term efficacy of pasireotide in a patient with Cushing's disease and diabetes: results in the short term are not always predictive of long-term response

Trementino Laura , Cardinaletti Marina , Concettoni Carolina , Marcelli Giorgia , Boscaro Marco , Arnaldi Giorgio

The management of Cushing’s disease (CD) can be problematic, particularly when the disease persists following pituitary surgery. Here we report the case of a 55-year old woman with CD that persisted after repeat transsphenoidal surgery. The patient had an overt phenotype with facial rubeosis, central obesity with supraclavicular fat accumulation, cervical fat pad and proximal muscle weakness. She had received anti-hypertensive drugs and insulin for diabetes mellitus. Horm...

ea0032p129 | Calcium and Vitamin D metabolism | ECE2013

Does recognition of vitamin D deficiency affect the indication for surgical treatment in asymptomatic primary hyperparathyroidism?

Gianotti Laura , Tassone Francesco , Pellegrino Micaela , Baffoni Claudia , Cassibba Sara , Magro Gianpaolo , Cesario Flora , Borretta Giorgio

Introduction: Current guidelines for the management of asymptomatic primary hyperparathyroidism (A-pHPT) recommend that 25-hydroxyvitamin D levels should be assessed in all patients and vitamin D deficiency (VDD) should be cautiously corrected. It is unknown whether VDD affects the probability to meet surgical criteria currently proposed for A-pHPT. Aim of study was to evaluate whether VDD recognition affects the probability to meet surgical criteria in A-pHPT patients.<p ...

ea0032p850 | Pituitary – Clinical (<emphasis role="italic">Generously supported by IPSEN</emphasis>) | ECE2013

Endoscopic transsphenoidal approach as a promising surgical option in the treatment of craniopharyngioma

Faustini-Fustini Marco , Zoli Matteo , Mazzatenta Diego , Santi Daniele , Brigante Giulia , Pasquini Ernesto , Frank Giorgio

Introduction: The management of craniopharyngioma (CR) remains a challenge. The introduction of endoscopic technique in the surgical approach to the sellar/suprasellar region would have profound implications for treatment. The aim of the study was to analyze results, advantages and limits of endoscopic endonasal approach (EEA).Design/methods: From 1998 to 2012, 95 patients underwent surgery for CR. Trancranial approach was chosen for 33 patients (35%) on...

ea0032p1106 | Thyroid cancer | ECE2013

Serum calcitonin, thyrotropin, and goiter

Grani Giorgio , D'Alessandri Mimma , Del Sordo Marianna , Carbotta Giovanni , Vitale Martina , Fumarola Angela

Objective: Recent papers reported that basal calcitonin (CT) level may be related to thyroid volume. This study aims to evaluate if this finding is confirmed in patients undergoing ultrasonography-guided fine-needle aspiration cytology (FNAC) for thyroid nodules.Design: Retrospective university-center study.Methods: From February 2010 to September 2012, 561 patients underwent ultrasonography-guided FNAC and a complete evaluation in...