Endocrine Abstracts

Background: Graves’ disease and Hashimoto’s thyroiditis are the most common autoimmune thyroid conditions. Hyperthyroidism following hypothyroidism is a rare phenomenon. Hypothyroidism was once thought to be a permanent state requiring lifelong replacement therapy but we have noted that there are increasing numbers of cases which are against this postulation. We would like to report 3 cases initially diagnosed with hypothyroidism and referred to us following developm...

Case: A 34 years old lady presented to the antenatal clinic at 7 weeks gestation with unplanned pregnancy. She had background history of HTN, poorly controlled T2DM and hypercholesterolemia . She continued taking metformin, gliclazide, sitagliptin and simvastatin which were stopped at the booking appointment . Metformin continued and started on insulin. Blood tests at booking showed HbA1c 126, Cholesterol 5.2 , Triglycerides 2.7. She was started on...

Case: A 34 years old lady presented to the antenatal clinic at 7 weeks gestation with unplanned pregnancy. She had background history of HTN, poorly controlled T2DM and hypercholesterolemia . She continued taking metformin, gliclazide, sitagliptin and simvastatin which were stopped at the booking appointment . Metformin continued and started on insulin. Blood tests at booking showed HbA1c 126, Cholesterol 5.2 , Triglycerides 2.7. She was started on...

Background: Graves’ disease is a common cause of thyrotoxicosis,especially amongst females. In the UK,initial treatment is usually with anti-thyroid drugs, using either a ‘block and replace’ or a titrating regime. A meta-analysis suggests about 50% chance of relapse after the initial course of treatment and may then require definitive cure with radioactive iodine or surgery.Method: A retrospective audit of patients with Graves’ di...

Introduction:: The hypothalamus is intimately involved in weight homeostasis. Pituitary tumours and treatment for pituitary tumours has been well described to induce obesity in certain subjects presumably due hypothalamic irritation or dysfunction. This is often very challenging to treat.GLP-1 analogues have direct central effects and have been shown to be effective for weight loss in obese patients with and without diabetes mellitus.<p class="abstex...

An 87 year old gentleman with type 2 diabetes mellitus was started on oral sodium fusidate for infected left middle toe ulcer. His blood test revealed Sodium 140 mmol/L, potassium 5.2 mmol/L, urea 25.3 mmol/L, creatinine 287 µmol/L, eGFR-19 ml/minute, albumin 29 g/L, adjusted calcium 2.17 mmol/L, and phosphate 0.95 mmol/L. Two days later he was admitted to hospital. Blood tests on admission showed severe hypocalcaemia with renal failure. (Sodium 146 mmol/LL, potassium 4.9...

Hypercalcaemia is a rare, albeit well-described feature of hypoadrenalism, although the mechanism underlying this is remains controversial. Primary adrenal failure is known to occur secondary to infective agents, and indeed tuberculous infiltration of adrenal tissue represents one of the leading aetiologies worldwide. Primary adrenal failure has also been shown to occur secondary to sepsis with Meningococcus or Pseudomonas species, but classically this presents w...

Objective: The aim of this article is to acknowledge coexistence of primary hyperparathyroidism, Cushing’s syndrome in a patient with previous history thyrotoxicosis treated with radioiodine. The presentation may be another variant of multiple endocrinal neoplasias.Is there a role of previous radioiodine therapy?Case report: A 67-year-old lady with past history of thyrotoxicosis treated with radioiodine. Now hypothyroid on thy...

A 68-year-old previously well man was referred to the endocrinology department in April 2007 with generalised tiredness and dizziness following a recent viral upper respiratory illness. He had no symptoms to suggest pituitary dysfunction. He was normotensive and lacked clinical features of hypopituitarism or dysthyroidism. Visual fields were normal to confrontation. Testicular volumes were normal. Initial baseline pituitary function tests (reference ranges in brackets): FT<sub...

A 62-year-old woman was referred to the endocrine clinic with new onset thyrotoxicosis. She had previously had two other conditions affecting her thyroid gland. In 1977, she underwent a right thyroid lobectomy for a non-functioning thyroid adenoma. In 2002, she presented with a rapidly enlarging left sided goitre, which proved to be thyroid B-cell lymphoma on core biopsy. She was treated with chemotherapy alone and remains under regular haematology follow up. Serial thyroid fu...