Endocrine Abstracts

Background: Hyperandrogenism and disrupted folliculogenesis are prominent features of polycystic ovary syndrome (PCOS) and are causatively linked to ovarian dysfunction. In PCOS, increased anti-Müllerian hormone (AMH) serum levels have been observed and related to the severity of the phenotype. However, the regulation of AMH in PCOS remains poorly understood. Therefore, we compared AMH secretory pattern after acute exposure to a GnRH-analogue in women affected by PCOS or ...

Introduction: Epidemiological studies indicate that patients with acromegaly have increased mortality rates for cardiovascular and cerebrovascular disease (CVD). Potentials risk factors for increased CVD include hypopituitarism and cranial radiation therapy (CRT).Case Report: A 43-year-old acromegalic woman was admitted because of worsening headache, left lower facial numbness and left arm weakness. Two weeks later she developed a central palsy of the le...

PurposeThe standard treatment of hypothyroidism is levothyroxine (LT4), which is available as tablets or soft-gel capsules in Denmark. This study aimed to investigate Danish endocrinologists’ use of thyroid hormones in hypothyroid and euthyroid patients.MethodAn e-mail with an invitation to participate in an online survey investigating practices about substitution with thyroid hormones was sent to all me...

Background and aimsIn the Republic of Belarus treatment of hypothyroidism in the adult population is regulated by the order of the Ministry of Health dated 2013. Levothyroxine is available in tablet form (dosage in increments of 25 µg). Liothyronine are not registered in the Republic of Belarus, but patients can purchase them on their own abroad. Thus, the aim was to study of possible endocrinologists’ preferences of choosing the levothyroxine ...

Background and aimsIt has been reported that some patients with hypothyroidism treated with levothyroxine continue to experience persistent symptoms despite normal serum TSH. Thus, the aim was to study of causes of hypothyroidism symptoms in euthyroid patients.Materials and methodsFrom 01.10.2020 to 26.12.2020 there was survey using THESIS questionnaire: Treatment of Hypothyroidism in Europe by Specialists: I...

Aim: Diagnostic definition and therapeutic interventions for nodular thyroid disease represent a high healthcare cost and their consequences may have a negative impact on quality of life of patients. This guideline aims at providing a reference for the management of non-functioning, benign thyroid nodules causing local symptoms in adults outside of pregnancy. The purpose is to standardize the treatment, based on the evidence provided by the GRADE method and the expertise of a ...

Background: Thyroid nodules are the most common endocrine pathology. Due to the widespread use of imaging modalities, mostly ultrasound, the incidental finding of thyroid nodules has increased, reaching a prevalence of 50-60% in adults. Diagnostic definition and therapeutic interventions represent thus an increasing cost for health system. In patient with benign thyroid nodule causing local symptoms, hemithyroidectomy with isthmectomy or total thyroidectomy are the recommended...

Polycystic ovary syndrome (PCOS) is an endocrine and metabolic disorder affecting women of reproductive age. The main features of PCOS are hyperandrogenism and reproductive and metabolic dysfunctions. We have previously shown that muscle contractions induced by either electrical stimulations or exercise act through partially similar signaling pathways in the muscle to induce glucose uptake in the acute response. Long-term electrical stimulations decrease circulating testostero...

Background: SARS-CoV-2 infection is characterized by aspecific symptoms (e.g., fever, cough) and can be complicated by viral pneumonia and many other manifestations can occur. Endocrinological complications have also been described. Pheochromocytomas are rare tumors located in the adrenal medulla, causing symptoms due to catecholamines overproduction and abrupt release. Catecholamines release can be continuous or intermittent and there can be several triggers including stress,...

Patients: Nineteen acromegalic patients (8 females, 21-69 years-old, with macroadenoma, microadenoma or no evidence of pituitary tumor in 15, 2, 2, respectively) resistant to first generation somatostatin analogs (FG-SA) at high doses and/or intolerant to pegvisomant were switched to pasireotide LAR (PasLAR). Eleven had persistent disease after neurosurgery and two had also undergone radiosurgery (12 and 24 months before starting PasLAR). Six complained of acromegalic headache...