Endocrine Abstracts

This 24-week, multicentre, open, parallel group study compared the efficacy and safety of two different regimens for initiating insulin therapy. Insulin-naive patients with fasting blood glucose (FBG) levels >=6.7 mmol/L (>=120 mg/dL) and HbA1c levels 7.5-10.5% on oral antidiabetic agents (OADs: glimepiride [Amaryl] or other sulfonylureas plus metformin) were randomized to insulin glargine (LANTUS) once daily in the morning with continued OADs (Glarg + OADs) o...

The endogenous growth hormone secretagogue (GHS), ghrelin, is an important regulator of energy homeostasis. Peripheral and central administration of ghrelin increase food intake, body weight and fat mass, effects which are mediated by the growth hormone secretagogue receptor type 1a (GHS-R 1a). Although the central actions of ghrelin on adiposity have been extensively studied, the direct peripheral effects of ghrelin on adipose tissue remain poorly understood. This study aimed...

Introduction: Cushing’s disease (CD) and acromegaly, despite their different specific symptoms, often present psychopathology (mainly depression and anxiety) even after hormonal normalization. However, their psychopathological profiles may be different. The aim of this study was to analyse the psychopathological profile in successfully treated Acromegaly and CD, and to compare both diseases. Current hormonal evaluation and time since endocrine control will also be analyse...

Introduction: Most goitres are asymptomatic and do not require surgical intervention. Surgical management is recommended for goitres with compressive symptoms, suspected malignancy, drug-resistant hyperthyroidism, or retrosternal extension.Case: 63-year-old female with a background history of hypertension, type 2 diabetes, obesity (BMI 43 kg/m2) and possible obstructive sleep apnoea (OSA), presented to Emergency Department following a one-minu...

Introduction: Multiple endocrine neoplasia–type 1 (MEN1) is an autosomal dominant cancer syndrome characterized by tumors in at least two of the following: parathyroid, endocrine pancreas, and anterior pituitary. MEN1 mutations may exhibit gonosomal mosaicism— a combination of somatic and germ-line tissue mosaicism. We present a family with gonosomal mosaicism in MEN1.Case Presentation: A 43-year-old man presented with sudden neck enlargement, ...

Background: NICE 2022 updated guidelines and the updated Irish guidelines (launched on 10th May 2024) in type 1 diabetes (T1D) in adults recommend the use of continuous glucose monitoring (CGM) based on individual preferences and needs. This study aimed to evaluate the outcomes of Dexcom real-time CGM (rt-CGM) in adults with T1D attending our regional diabetes service.Methods: A retrospective data analysis was conducted from the Dexcom Clarity...

Background: Studies have shown that body mass index (BMI) thresholds for defining overweight and obesity among South Asian (SA) adults should be lower than those for White Caucasians (WC) due to increased risk of type 2 diabetes (T2D). Although children and adolescents of SA ethnicity are known to be at increased risk of insulin resistance and T2DM at lower BMI threshold, there are no guidelines to define adjusted overweight/obesity thresholds for SA children compared to WC ch...

Background: Thyroid imaging is recommended in the workup of children suspected with Congenital Hypothyroidism (CHT). Many centres in UK currently do not undertake scintigraphy routinely in CHT workup due to pitfalls such as unavailability, questionable benefit over ultrasound, result may not influence decision to treat or not, time constraints to complete scan within 5 days of starting treatment, etc.Aim: Retrospective analysis of scintigraphy data in di...

Polycyclic aromatic hydrocarbons (PAHs) are common environmental pollutants derived from the incomplete combustion of organic materials. In urban and industrial areas, level of pollution with these compounds is high, which leads to numerous negative health effects. Some literature data indicate the involvement of PAHs in the development of obesity, however, there is no data showing the distribution patterns of PAHs in human adipose tissue (AT) and their impact on the process o...

Introduction: A number of studies indicate the presence of a thyroid-gut axis and the important influence of the gut microbiota on thyroid function. As prebiotics, probiotics and synbiotics show therapeutic potential in the treatment of intestinal dysbiosis, we aimed to evaluate the efficacy of their supplementation in patients with primary hypothyroidism.Material and methods: We searched electronic databases (Ovid MEDLINE, Embase, CENTRAL), registers of...