Searchable abstracts of presentations at key conferences in endocrinology

ea0073aep866 | Late Breaking | ECE2021

Effectiveness of iodine supplementation during pregnancy in western Poland – a single center study

Filipowicz Dorota , Ada Mikulska Aniceta , Marta Karaźniewicz-Łada , Ewelina Szczepanek-Parulska , Franciszek Glówka , Ruchala Marek

IntroductionTwenty-four years after implementing the national salt iodization programme in Poland in 1997, the country is considered as adequate iodine supply. However, most reports do not take into consideration pregnant or lactating females. Additional intake of 150–200 µg KI per day, independently on levothyroxine (LT4) treatment, is a recommended dose for pregnancy and lactation due to Polish endocrinological guidelines. The study aim was t...

ea0049ep113 | Clinical case reports - Pituitary/Adrenal | ECE2017

Von Hippel Lindau disease in two Turkish families with different mutations

Adaş Mine , Toprak İlkim Deniz , Bayraktarli Recep Yılmaz

Von Hippel-Lindau (VHL) disease is an inherited, autosomal dominant syndrome manifested by a variety of benign and malignant tumors. Herein we describe, two families who had VHL. A 21-year-old man (index case 1) presented with bilateral adrenal mass, serendipitously discovered by radiologic examination. He had newly diagnosed arterial hypertension. His family history was significant for his mother who had operated for pheochromocytoma, his two uncles who had experienced cerebr...

ea0059oc6.1 | Neuroendocrinology and Reproduction | SFEBES2018

A controlled cross-sectional study of bone microarchitecture in transgender individuals

Zajac Jeffrey D , Bretherton Ingrid , McFarlane Thomas , Spanos Cassandra , Grossmann Mathis , Cheung Ada S

Sex steroids have complex effects: testosterone predominantly regulates trabecular and estradiol, cortical bone1. Studies in transgender individuals use insensitive technology and report conflicting effects2. We hypothesized estradiol therapy will increase cortical volumetric bone mineral density (vBMD) in male-to-female (MtF) individuals and testosterone therapy will increase trabecular vBMD in female-to-male (FtM) individuals.Aims...

ea0038p212 | Obesity, diabetes, metabolism and cardiovascular | SFEBES2015

Distinguishing different subtypes of aldosterone-producing adenoma by histological, immunohistochemical and radiological features; a basis for individualised treatment strategies in primary aldosteronism?

Powlson Andrew S , Teo Ada , Haris Lalarukh , Maniero Carmela , Marker Alison , Azizan Elena , Gurnell Mark , Brown Morris J

Background: Primary aldosteronism (PA) is now recognised to account for 5–10% of all cases of hypertension (and 20–25% of refractory hypertension). For patients with a demonstrable unilateral cause, adrenalectomy offers the potential for cure of PA, although resolution of hypertension occurs in only ~50% of patients. We have examined histological appearances and radiological features in patients with APAs undergoing adrenalectomy in an attempt to further our understa...

ea0075r09 | Reproductive Endocrinology | EYES2021

Evaluation of the urinary iodine concentration (UIC) in pregnant women using ion-pair HPLC-UV method

Mikulska Aniceta , Filipowicz Dorota , Głowka Franciszek , Szczepanek-Parulska Ewelina , Ruchała Marek , Karaźniewicz-Łada Marta

Background: Pregnancy is a state of a higher iodine intake demand. Proper iodine status is important during pregnancy for fetal neurodevelopment and maternal thyroid function. Urinary iodine concentration (UIC) is the most common indicator of iodine status.Objectives: The aim of this study was to develop and validate a novel ion-pair HPLC-UV method to measure iodine in urine and to assess iodine status in pregnant women.Methods: Sa...

ea0059p011 | Adrenal and steroids | SFEBES2018

Androgen deprivation therapy causes selective loss of levator ani and leg muscle volumes

Zajac Jeffrey D , Cheung Ada S , Ly Vivian , Cunningham Christopher , Ko Dong-Kyoon , Gray Hans , Hoermann Rudolf , Strauss Boyd J G , Hassan Ebrahim Bani , Duque Gustavo , Pandy Marcus G , Grossmann Mathis

Background: Androgen deprivation therapy (ADT) for prostate cancer (PCa) leads to a global loss of lean mass. ADT leads to sexual dysfunction and a selective loss of leg muscle function, however individual muscle volumes have never been evaluated. We aimed to assess in men undergoing ADT, the muscle volumes of levator ani, which in mice is androgen-responsive, and of lower-limb muscles.Methods: We conducted a prospective case-control study involving 34 m...

ea0077oc4.2 | Adrenal and Cardiovascular | SFEBES2021

Somatic mutations of GNA11 and GNAQ in CTNNB1-mutant aldosterone-producing adenomas presenting in puberty, pregnancy or menopause.

Argentesi Giulia , Azizan Elena , Zhou Junhua , Cabrera Claudia , O’Toole Sam , Wu Xilin , Goodchild Emily , Cottrell Emily , Marker Alison , Senanayake Russell , Garg Sumedha , Jordan Suzanne , Berney Dan , Gluck Anna , Lines Kate , Thakker Rajesh V , Tuthill Antoinette , Joyce Caroline , Karet Frankl Fiona , Metherell Lou , Teo Ada , Gurnell Mark , Parvanta Laila , Drake William , Wozniak Eva , Mein Chaz , Kinsler Veronika , Storr Helen , Brown Morris

Most aldosterone-producing adenomas (APAs) have gain-of-function somatic mutations of ion channels or transporters. However, their frequency in aldosterone-producing cell-clusters of normal adrenals could suggest the existence of co-driver mutations which influence the development or phenotype of APAs [1]. Gain-of-function mutations in both CTNNB1 and the G-protein coupled receptor GNA11 were found by whole exome sequencing in 3/10 APAs. Further sequencing of...

ea0070aep598 | Pituitary and Neuroendocrinology | ECE2020

The importance of DHEA-S levels in cushing’s syndrome; is there a cut-off value in the differential diagnosis?

Ciftci Dogansen Sema , Soyluk Selcukbiricik Ozlem , Selek Alev , Erol Selvinaz , Hekimsoy Zeliha , Esen Pazir Ayse , Dursun Huseyin , Sahin Serdar , Oruk Gonca , Mert Meral , Soylu Hüseyin , Sarer Yurekli Banu , Eda Ertorer Melek , Omma Tülay , Evran Mehtap , Adaș Mine , Tanrikulu Seher , Aydin Kadriye , Pekkolay Zafer , Can Bulent , Karakilic Ersen , Karaca Zuleyha , Bilen Habib , Canturk Zeynep , Cetinarslan Berrin , Kadioglu Pinar , Yarman Sema

Purpose: To evaluate the relationship between basal dehydroepiandrosterone-sulfate (DHEA-S) levels and other tests used in the diagnosis and differential diagnosis of Cushing’s Syndrome (CS) among the patients with pathologically confirmed CS.Methods: In this multicenter study, the data of 623 patients with CS were evaluated retrospectively. The patients were classified as Group 1 (n = 353 Cushing’s disease;CD), Group 2 (n</e...