Searchable abstracts of presentations at key conferences in endocrinology

ea0041ep17 | Adrenal cortex (to include Cushing's) | ECE2016

Psychopathology, memory and quality of life in Cushing’s syndrome

Santos Alicia , Resmini Eugenia , Crespo Iris , Valassi Elena , Martinez Maria Antonia , Pires Patricia , Webb Susan

Introduction: Cushing’s syndrome (CS) has been related to higher psychopathology. Psychopathology can be related to poor memory performance, and low quality of life. The aim of this study is to establish the relationship between the three parameters and with subjective symptom perception in CS.Methods/design: Thirty six patients in remission of CS and 36 matched controls for age, sex and education years were included in the study. They completed SCL...

ea0037gp.02.06 | Adrenal (1) | ECE2015

DNA methylation of FKBP5 and its relationship with hippocampal volumes in Cushing's syndrome patients

Resmini Eugenia , Santos Alicia , Aulinas Anna , Webb Susan , Gomez-Anson Beatriz , Cox Olivia , Lee Richard

Introduction: FKBP5 is a protein that regulates glucocorticoid receptor sensitivity, via an ultra-short negative feedback mechanism. Variations in the FKBP5 gene can influence the response to glucocorticoids (GC). Hypercortisolaemia plays a role on impairment of brain function and could be mediated by epigenetic variations of the FKBP5 gene. Cushing’s syndrome (CS), a disease characterized by hypercortisolaemia, is associated with memory deficits, lower ...

ea0070ep292 | Pituitary and Neuroendocrinology | ECE2020

Quality of life in patients with Cushing’s syndrome in remission: 10-year follow-up

Santos Alicia , Resmini Eugenia , Martinez Momblan Mª Antonia , Medina Marc , Webb Susan

Introduction: Cushing’s syndrome (CS) has been associated with low quality of life, even after biochemical cure. However little data is available on long term follow-up. The aim of the study was to analyse 10-year follow-up of quality of life (QoL) in patients in remission of CS.Methods: 24 patients in remission of CS followed in Hospital Sant Pau were included in this study (3 men, 21 pituitary origin, 3 adrenal; mean baseline age 45.1 ± 14.1...

ea0022s1.6 | European networks | ECE2010

The European Registry on Cushing's syndrome (ERCUSYN) database: first year experience

Webb Susan , Santos Alicia , Trainer Peter , Strasburger Christian , Lamberts Steven , Wass John , Feelders Richard , Franz Holger

The ERCUSYN (European Registry on Cushing’s syndrome (CS)) study is a project funded by the European Commission Public Health Program (PHP 800200), of which the ESE is one of the 41 Partners from 25 countries. The aims include obtaining prospective and follow-up data at EU level on epidemiology, mortality, outcome of therapies, co-morbidities, assessment of diagnostic and therapeutic strategies, quality of life evaluation using a disease-generated questionnaire (CushingQo...

ea0056p852 | Pituitary - Clinical | ECE2018

Psychopathology in Cushing’s disease and acromegaly

Santos Alicia , Resmini Eugenia , Crespo Iris , Valassi Elena , Martinez Ma Antonia , Webb Susan M

Introduction: Cushing’s disease (CD) and acromegaly, despite their different specific symptoms, often present psychopathology (mainly depression and anxiety) even after hormonal normalization. However, their psychopathological profiles may be different. The aim of this study was to analyse the psychopathological profile in successfully treated Acromegaly and CD, and to compare both diseases. Current hormonal evaluation and time since endocrine control will also be analyse...

ea0037ep64 | Adrenal cortex | ECE2015

Serum brain-derived neurotrophic factor in Cushing's syndrome patients

Santos Alicia , Resmini Eugenia , Barahona Ma Jose , Crespo Iris , Valassi Elena , Martinez Ma Antonia , Marin Ana , Webb Susan M

Introduction: Brain-derived neurotrophic factor (BDNF) is a protein that has been linked to several cardiovascular risk factors and bone status. Stress and corticosteroid exposure can affect BDNF levels, although this has never been studied in Cushing’s syndrome (CS). The aims of this study were to establish if BDNF levels were reduced in CS and to check possible associations to cardiovascular risk factors and bone status.Methods: 52 patients (18 ac...

ea0037gp.22.06 | Pituitary–Therapy of Cushing's disease | ECE2015

A specific nursing educational programme in patients with Cushing's syndrome

Martinez-Momblan M Antonia , Porta Nuria , Gomez Carmen , Esteve Julia , Santos Alicia , Ubeda Inmaculada , Halperin Irene , Campillo Beatriz , Guillaumet Montserrat , Webb Susan M , Resmini Eugenia

Context: Cushing’s syndrome (CS) is a rare endocrine disease, due to cortisol hypersecretion. CS patients have several comorbidities, often still present after biochemical cure. There are no specific nursing healthcare programs to address this disease and achieve improved health related quality of life (HRQoL). Thus, an educational nursing intervention in these patients, through the development and promotion of specific educational tools, appears to be justified.<p cl...

ea0035oc12.5 | Pituitary Basic | ECE2014

Does hypercortisolism of Cushing’s syndrome affect telomere length?

Aulinas Anna , Ramirez Maria Jose , Barahona Maria Jose , Valassi Elena , Resmini Eugenia , Mato Eugenia , Santos Alicia , Crespo Iris , Bell Olga , Surralles Jordi , Webb Susan

Introduction: Hypercortisolism in Cushing’s syndrome (CS) determines increased mortality and morbidity. Hypercortisolism is also present in chronic depressive disorders and stress, where telomere length (TL) is shorter than in controls. We hypothesized that telomere shortening may occur and contribute to premature morbidity in CS.Aim: Investigate TL in CS compared to matched controls, and longitudinally in a subset of CS patients evaluated both with...

ea0032oc4.4 | Adrenal | ECE2013

Neuronal dysfunction in the hippocampi of cured Cushing's syndrome patients, detected by 1H-MR-spectroscopy

Resmini Eugenia , Santos Alicia , Gomez-Anson Beatriz , Lopez-Mourelo Olga , Pires Patricia , Vives-Gilabert Yolanda , Crespo Iris , Portella Maria , de Juan-Delago Manel , Webb Susan

Introduction: Proton magnetic resonance spectroscopy (1H-MRS) is a sensitive, non-invasive imaging technique capable of measuring brain metabolites in vivo. Chronic exposure to endogenous hypercortisolism in Cushing’s syndrome (CS) is associated with negative effects on memory and hippocampal volumes, even after biochemical cure.Objective: To investigate metabolites in the hippocampi of CS patients and controls, using 1</sup...

ea0020p583 | Neuroendocrinology, Pituitary and Behaviour | ECE2009

Adiponectin and visfatin: a link with bone mineral density in acromegaly

Resmini Eugenia , Sucunza Nuria , Barahona M Jose , Santos Alicia , Fernandez-Real J Maria , Ricart Wilfredo , Moreno J Maria , Farrerons Jose , Espinosa Jose Rodriguez , Marin AM , Webb Susan M

Two adipokines highly expressed in fat mass, adiponectin with antiinflammatory and antiatherogenic properties, and visfatin with an insulin-mimetic effect, are potential contributors to bone metabolism. In acromegaly data on adiponectin are contradictory and there are no data on visfatin.Objectives: To evaluate adiponectin and visfatin in acromegaly, compared to control subjects and to analyze their relationship with body composition and bone mineral mar...