Searchable abstracts of presentations at key conferences in endocrinology

ea0070aep664 | Pituitary and Neuroendocrinology | ECE2020

The role of repeated prolactin samples in patients with hyperprolactinaemia

Rodrigues Catarina , Cunha Filipe , Chaves Catarina , Silva Vieira Margarida , Silva André , Garrido Susana , Martinho Mariana , Almeida Margarida

Introduction: Current guidelines recommend a single prolactin sampling for the diagnosis of hyperprolactinaemia. Nonetheless, in some patients, prolactin levels may normalize in a subsequent sampling or if prolactin is collected through a venous catheter some time after puncture. We aimed to assess the percentage of patients in which prolactin remained elevated in repeated sampling and to determine the best prolactin cutoff associated with persistent hyperprolactinaemia.<p...

ea0070aep769 | Pituitary and Neuroendocrinology | ECE2020

Empty sella: Who thinks of it while studying hyponatremia?

Ramalho Ana , Costa Joana , Carvalho João , Maria Amador Susana , Resendes Sousa André , Marques Santos Sofia , Cantante Helena

Hyponatremia is a common disorder, especially among the elderly, and an important morbidity and mortality cause. Empty sella syndrome, on the other hand, is a rare entity, more common in women between their fourth and sixth decade of life, and endocrine dysfunction has been reported in 10–60% of the cases. A 68-year-old man, with a past medical history of essential hypertension and glaucoma, presented at the emergency room due to malaise, asthenia, somnolence and anorexi...

ea0073oc10.3 | Oral Communications 10: Thyroid | ECE2021

Predictive factors for recurrent non-diagnostic fine-needle aspiration biopsy in thyroid nodules

Benido Silva Vânia , Maria Teresa Vânia , Carvalho André , Freitas Cláudia

IntroductionThe most cost-effective, minimally invasive and accurate tool to discriminate benign from malignant thyroid nodules is a fine-needle aspiration biopsy (FNAB). However, 2%–24% of FNABs provide non-diagnostic results, which are a clinical challenge, particularly when this result is recurrent.AimTo determine the predictive factors for recurrent non-diagnostic FNAB in thyroid nodules.<p class...

ea0073pep5.3 | Presented ePosters 5: Thyroid | ECE2021

Is the thyroid nodule location associated with the risk of malignancy?

Vânia Benido Silva , Pereira Maria Teresa , André Carvalho , Cláudia Freitas , Maria Helena Cardoso

IntroductionRecent published studies suggest that the anatomical location of the thyroid nodule may be associated with different risks of malignancy. However, the results are still sparce and little consensual.AimTo evaluate the frequency of nodules on different locations of the thyroid gland and to determine whether their location correlates with different malignancy risks.Methods<...

ea0073aep137 | Calcium and Bone | ECE2021

Predictive factors for postoperative hypoparathyroidism after total thyroidectomy

Santos Tiago , André Carvalho , Cláudia Freitas , Raquel da Inez Correia , Costa Moreira da , Cardoso Maria Helena

IntroductionHypoparathyroidism (hypoPT) is one of the most complications after thyroid surgery, usually as transient hypocalcemia. Permanent hypoPT due to permanent parathyoid lesion, despite being less frequent, is associated to long term consequences for both objective and subjective well-being and should be prevented. Identifying predictive factors associated with post- thyroidectomy hypoPT is thereby crucial.Aim<p class="ab...

ea0070aep7 | Adrenal and Cardiovascular Endocrinology | ECE2020

Investigation of angiotensin II induced gene expression changes in vascular smooth muscle cells

Balla András , Szalai Laura , Gém Janka , Kovács Kinga , Szakadáti Gyöngyi , Hunyady László

The angiotensin II (AngII) hormone exerts a number of biological effects through the type 1 angiotensin II receptor (AT1R). One of the main targets of AngII are vascular smooth muscle cells, their stimulation activates many signaling pathways and results in gene expression changes.Affymetrix Gene Chip experiments were performed to analyze the effects of AngII stimulation on gene expression. For the determinations, aortic thoracic aorta from young male Wi...

ea0014p97 | (1) | ECE2007

Localization of an ectopic adrenocorticotropin-secreting tumour using 18F- Dopa PET/CT

Dubois Séverine , Morel Olivier , Rodien Patrice , Jeanguillaume Christian , Enon Bernard , Illouz Frédéric , Saint-André Jean-Paul , Girault Sylvie , Rohmer Vincent

Ectopic adrenocorticotropin secretion (EAS) accounts for 10–15% of cases of Cushing’s syndrome and comprises a spectrum of lesions from highly malignant tumours to a variety of less aggressive neuroendocrine tumours. Selective removal of the primary lesion is the optimal management. It is therefore mandatory to localize the source of ectopic ACTH.As no single test is accurate enough to distinguish the ectopic from the pituitary sources of ACTH,...

ea0014p295 | (1) | ECE2007

Fine needle aspiration biopsy of the thyroid. Cytohistologic correlation: experience in a central military hospital

Nobre Ema Lacerda , Vilar Helena , Jorge Zulmira , Marcelino Mafalda , André Saudade , Guerra Paulo , Lopes Carlos , de Castro João Jácome

Background and aims: Thyroid nodular disease (TND) is a common condition in the general population. Malignant nodules occur in 5% of patients with thyroid nodules. Fine-needle aspiration biopsy (FNAB) is considered to be the most reliable method of differentiating benign and malignant thyroid nodules. The purpose of this study was to assess the accuracy of FNABs performed in our Hospital.Methods: We retrospectively reviewed the medical records of patient...

ea0073oc7.2 | Oral Communications 7: Diabetes, Obesity, Metabolism and Nutrition | ECE2021

Hepatocyte GH signaling regulates carbohydrate processing in a STAT5b-independent manner

Vázquez-Borrego Mari C. , Del Rio-Moreno Mercedes , Sarmento-Cabral André , Mariyah Mahmood , Cordoba-Chacon Jose , Puchowicz Rhonda , Kineman Rhonda

In the healthy liver, GH signals through multiple pathways to modulate hepatic function, with JAK2/STAT5b required to maintain circulating IGF1 levels. It has been previously reported that mice with developmental knockout of hepatocyte GHR, JAK2 or STAT5 develop steatosis associated with glucose intolerance, systemic insulin resistance and white adipose tissue (WAT) lipolysis. These changes are thought to be secondary to increased circulating GH, due to loss of IGF1 negative f...

ea0073aep756 | Thyroid | ECE2021

Papillary thyroid cancer presenting with splenic infarction

Saraiva Miguel , Magda Garça , Rita Costa Ana , Pinheiro Guiomar , Rita Cruz Ana , Ribeiro Sofia , Cláudia Freitas , André Carvalho

IntroductionThe close relationship between cancer and thrombotic phenomena has been widely recognized and paraneoplastic organ infarctions may occur. Reports of papillary thyroid cancer associated to paraneoplastic phenomena are particularly scarce.Case reportA 39-year-old man with no prior relevant medical history was evaluated for acute onset of fever, malaise and mild pain referred to his left hypochondriu...