Endocrine Abstracts

Somatostatin analogues are the first line therapy for patients with functioning neuroedocrine tumours. These drugs prevent the release of peptides which cause symptoms in patients with neuroendocrine tumours. Correct and proper preparation and administration of the analogues are vital in the care of patients. The somatostatin analogues not only provide relief of symptoms, benefiting the patient, but improve the quality of life for patients. The cost of the analogues to the hea...

Introduction: Gallstone disease is one of most common in the Europe with prevalence till 15%. The basic mechanism of stone formation is precipitation of cholesterol crystals in the supersaturated bile. The relationship between thyroid function and the content of cholesterol has been known for quite a long time, as well as the work confirming the relationship between hypothyroidism and cholelithiasis. Recently, in mice it has been shown that both hypothyroidism and hyperthyroid...

Context: Obesity is accompanied by blunted GH secretion but relatively normal serum IGF-I levels, which suggests increased GH sensitivity. This, however, remains to be tested at the level of GH signaling in human subjects.Objective: To compare the effects of an acute intravenous GH bolus in obese vs normal weight subjects on GH signaling pathways in adipose and muscle tissue, substrate metabolism and insulin sensitivity.Subjects an...

Introduction: Very late step growth is quite rare, and probably very rare, if there is, 10 years after the end of treatment with GH. Therefore, we would like to present our patient, even though we cannot yet give a full pathomechanism of his disorders.Case report: A man 28 years, was admitted to us to assess hormonal status before elective hip surgery. He had congenital brain toxoplasmosis. From 8 to 16 years he was treated with GH without a good effect....

Background: Hypothyroidism due to autoimmune thyroiditis leads to atherogenic lipid profile and metabolic changes. The formation of advanced glycation end products (AGEs) increases with hyperglycemia, hyperlipidemia and oxidative stress. Degradation of AGEs after AGEs-receptor 1-mediated intracellular uptake and renal clearance of soluble AGEs generated by certain cells like macrophages play a crucial role in the decrement of circulating AGEs level. Chemerin is an adipokine pr...

Background: Fibroblast growth factor 21 (FGF21) is a hormonal regulator of lipid and glucose metabolism exerting protection against atherosclerosis by multiple actions on the blood vessels, liver, and adipose tissues. Enhanced FGF21 production in diabetes and obesity reduces the level of LDL-C and triglycerides by suppression of hepatic SREBP-2. Hypothyroidism has also been shown to have unfavorable effects on atherogenesis and dyslipidemia. To date, the association of lipid p...

Background: Papillary thyroid microcarcinoma (PTMC) is a papillary thyroid cancer (PTC) type with a maximum diameter of ≤ 10 mm. Generally, PTMCs have good prognosis and low mortality risk. However, there are cases of PTMCs showing more biologically aggressive characteristics, such as lymph node (LN) involvement and distant metastasis.Objectives: Reveal the factors affecting the prognosis and aggressiveness of PTMCs.Methods: ...

Introduction: Papillary thyroid microcarcinomas (PTMC) are usually detected incidentally. They occur as a result of histological/microscopic examination of a thyroid removed especially for nodular goiter. Generally, the prognosis is good. However, it has been reported that lymph node (LN) metastasis is more common especially in PTMCs with tumor size > 5mm. In this study, it was aimed to show the effect of tumor size on prognosis by comparing clinicopathological data in pat...

Introduction: Congenital central hypothyroidism occurs either as isolated TSH deficiency or in conjunction with other pituitary hormone deficits. Undetected central hypothyroidism is associated with developmental delay in children and adverse cardiometabolic sequelae in adults. Hitherto, mutations in the TRH receptor (TRHR) or TSHβ subunit (TSHB) genes are the only known causes of isolated TSH deficiency.Methods: Using whole exome and candidate gene...

Introduction: Congenital central hypothyroidism occurs either as isolated TSH deficiency or in conjunction with other pituitary hormone deficits. Undetected central hypothyroidism is associated with developmental delay in children and adverse cardiometabolic sequelae in adults. Hitherto, mutations in the TRH receptor (TRHR) or TSHβ subunit (TSHB) genes are the only known causes of isolated TSH deficiency.Methods: Using whole exome and candidate gene...