Searchable abstracts of presentations at key conferences in endocrinology

ea0065oc6.6 | Reproductive Endocrinology and Biology | SFEBES2019

Kisspeptin enhances the brain processing of attraction in men

Yang Lisa , Demetriou Lysia , Wall Matt , Mills Edouard , Zargaran David , Sykes Mark , Prague Julia , Abbara Ali , Owen Bryn , Bassett Paul , Rabiner Eugenii , Comninos Alexander , Dhillo Waljit

Background: Successful reproduction relies on integration of sensory cues of attraction with corresponding emotions and behaviours. However, the intrinsic factors integrating these fundamental aspects of human attraction with limbic and reproductive pathways have not been fully identified. Kisspeptin is a crucial activator of the reproductive axis and together with its receptor is widely expressed throughout the limbic and olfactory systems in humans suggesting a potential rol...

ea0073ep54 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

Effects of a single-centre lifestyle modification programme on anthropometric, metabolic, and cardiovascular risk factors in adults with severe obesity

Brazil John , Finucane Francis , Gibson Irene , Collins Chris , Maguire Brian , Hynes Mary , Bakir Mustafa , Dunne Denise , Foy Siobhan , Seery Suzanne , Bassett Paul , Davenport Colin

BackgroundStructured lifestyle modification programmes are offered as first line treatment to patients referred to bariatric specialist services. We sought to describe changes in anthropometric and metabolic characteristics in a cohort of bariatric patients following completion of an eight-week, multidisciplinary group-based lifestyle intervention focussed on diet and physical activity.MethodsWe conducted a p...

ea0094oc4.3 | Reproductive Endocrinology | SFEBES2023

Self-administering post-cycle therapy is associated with biochemical gonadal recovery in men stopping anabolic-androgenic steroid use

Grant Bonnie , Campbell John , Pradeep Anjali , Burns Angela D. , Bassett Paul , Abbara Ali , Saket Priyadarshi , Minhas Sukhbinder , Dhillo Waljit S. , McVeigh James , Bhasin Shalender , Jayasena Channa N.

Background: Millions of men worldwide take anabolic-androgenic steroids (AAS) to boost muscle growth, but risk psychosis, cardiomyopathy, stroke and death. Users avoid stopping AAS because they are fearful of low testosterone symptoms including sexual dysfunction, depression and suicidality. To avoid these symptoms, men often illicitly self-medicate a 2–12-week course of drugs including selective oestrogen receptor modulators to boost testicular function ...

ea0077oc1.1 | Reproductive and Neuroendocrinology | SFEBES2021

Melanocortin-4 receptor agonism improves sexual brain processing in women with low sexual desire

Thurston Layla , Hunjan Tia , Mills Edouard , Wall Matthew , Ertl Natalie , Phylactou Maria , Muzi Beatrice , Patel Bijal , Alexander Emma , Suladze Sofiya , Modi Manish , Eng Pei , Bassett Paul , Abbara Ali , Goldmeier David , Comninos Alexander , Dhillo Waljit

Hypoactive sexual desire disorder (HSDD) is the most prevalent female sexual health complaint worldwide, affecting 1-in-10 women. It is characterised by a persistent lack of desire for sexual activity and sexual fantasies, causing distress or interpersonal difficulties. Treatment options are limited, however, melanocortin-4 receptor (MC4R) agonists have emerged as a promising therapy for HSDD, through unclear mechanisms. Investigating the pathways involved is crucial for our u...

ea0081p151 | Pituitary and Neuroendocrinology | ECE2022

Sexual brain processing is enhanced by melanocortin-4 receptor agonism

Thurston Layla , Hunjan Tia , Mills Edouard , Wall Matt B , Ertl Natalie , Phylactou Maria , Muzi Beatrice , Patel Bijal , Alexander Emma , Suladze Sofiya , Modi Manish , Eng Pei , Bassett Paul , Abbara Ali , Goldmeier David , Comninos Alexander , Dhillo Waljit

Introduction: Hypoactive sexual desire disorder (HSDD) is characterized by a persistent deficiency of sexual fantasies and desire for sexual activity, causing marked distress or interpersonal difficulty. It is the most prevalent female sexual health problem worldwide, affecting approximately 1 in 10 women, but has limited treatment options despite its substantial health, social, and economic burden. Melanocortin-4 receptor (MC4R) agonists have emerged as a promising therapy fo...

ea0086oc3.6 | Reproductive and Neuroendocrinology | SFEBES2022

Kisspeptin enhances sexual and attraction brain processing in women with low sexual desire

Thurston Layla , Hunjan Tia , Ertl Natalie , Wall Matthew , Mills Edouard , Suladze Sofiya , Patel Bijal , Alexander Emma , Muzi Beatrice , Bassett Paul , Rabiner Eugenii , Bech Paul , Goldmeier David , Abbara Ali , Comninos Alexander , Dhillo Waljit

Hypoactive sexual desire disorder (HSDD) is a persistent lack of sexual desire, causing marked interpersonal distress. It is the most common global female sexual health problem, although the precise pathophysiology remains uncertain. Existing treatment options are limited by their efficacy and side effects. The neuropeptide kisspeptin offers a potential therapeutic target given its emerging role in modulating reproductive behaviour. Using a combination of psychometric, neuroim...

ea0044oc1.3 | Early Career Oral Communications | SFEBES2016

Investigating the interaction between KNDy peptides on gonadotrophin release in humans – novel findings with therapeutic importance

Narayanaswamy Shakunthala , Prague Julia K , Jayasena Channa N , Papadopoulou Deborah A , Mizamtsidi Maria , Shah Amar J , Bassett Paul , Comninos Alexander N , Abbara Ali , Bloom Stephen R , Veldhuis Johannes D , Dhillo Waljit S

Background: Hypothalamic KNDy neurons have recently been identified as key regulators of reproductive function by releasing three neuropeptides namely kisspeptin, neurokinin B (NKB) and dynorphin. Animal studies show they interact to control pulsatile GnRH release, which is vital for fertility. In animals, kisspeptin stimulates, NKB modulates and the opioid dynorphin inhibits GnRH pulsatility. However, the interaction of these peptides has never been studied in humans. To inve...

ea0050oc5.2 | Reproduction and Neuroendocrinology | SFEBES2017

Kisspeptin modulates resting brain activity to alter responses to negative stimuli in humans

Comninos Alexander , Demetriou Lysia , Wall Matt , Shah Amar , Clarke Sophie , Narayanaswamy Shakunthala , Nesbitt Alexander , Izzi-Engbeaya Chioma , Prague Julia , Abbara Ali , Ratnasabapathy Risheka , Yang Lisa , Salem Victoria , Nijher Monica , Jayasena Channa , Tanner Mark , Bassett Paul , Mehta Amrish , Rabiner Ilan , Bloom Stephen , Dhillo Waljit

Kisspeptin is a crucial activator of reproductive function, stimulating GnRH neurons in the hypothalamus. However, kisspeptin and its receptor are also expressed in other brain regions including the limbic system, which has key roles in emotional processing. Kisspeptin signalling in the limbic system modulates emotional and sexual brain processing during tasks, however the effects of kisspeptin on underlying resting brain activity have not yet been studied. This is vital for o...